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STRUCTURE OF THE PERIPLASMIC GLUCOSE/GALACTOSE RECEPTOR OF SALMONELLA TYPHIMURIUM
分子名称:	CALCIUM ION, GALACTOSE-BINDING PROTEIN, beta-D-glucopyranose
著者	Mowbray, S.L.
登録日	1990-01-25
公開日	1991-07-15
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Structure of the periplasmic glucose/galactose receptor of Salmonella typhimurium. Receptor, 1, 1990

2CJP

Structure of potato (Solanum tuberosum) epoxide hydrolase I (StEH1)
分子名称:	1,2-ETHANEDIOL, 2-PROPYLPENTANAMIDE, EPOXIDE HYDROLASE, ...
著者	Mowbray, S.L, Elfstrom, L.T, Ahlgren, K.M, Andersson, C.E, Widersten, M.
登録日	2006-04-05
公開日	2006-06-07
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.95 Å)
主引用文献	X-Ray Structure of Potato Epoxide Hydrolase Sheds Light on Substrate Specificity in Plant Enzymes. Protein Sci., 15, 2006

1DBP

IDENTICAL MUTATIONS AT CORRESPONDING POSITIONS IN TWO HOMOLOGOUS PROTEINS WITH NON-IDENTICAL EFFECTS
分子名称:	D-RIBOSE-BINDING PROTEIN, beta-D-ribopyranose
著者	Mowbray, S.L, Joakim Bjorkman, A.J.
登録日	1994-01-31
公開日	1994-05-31
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Identical mutations at corresponding positions in two homologous proteins with nonidentical effects. J.Biol.Chem., 269, 1994

2DRI

PROBING PROTEIN-PROTEIN INTERACTIONS: THE RIBOSE BINDING PROTEIN IN BACTERIAL TRANSPORT AND CHEMOTAXIS
分子名称:	D-RIBOSE-BINDING PROTEIN, beta-D-ribopyranose
著者	Mowbray, S.L, Cole, L.B.
登録日	1994-09-23
公開日	1995-01-26
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Probing protein-protein interactions. The ribose-binding protein in bacterial transport and chemotaxis. J.Biol.Chem., 269, 1994

1DRJ

PROBING PROTEIN-PROTEIN INTERACTIONS: THE RIBOSE-BINDING PROTEIN IN BACTERIAL TRANSPORT AND CHEMOTAXIS
分子名称:	D-RIBOSE-BINDING PROTEIN, beta-D-ribopyranose
著者	Mowbray, S.L, Bjorkman, A.J, Cole, L.B.
登録日	1994-09-23
公開日	1995-01-26
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Probing protein-protein interactions. The ribose-binding protein in bacterial transport and chemotaxis. J.Biol.Chem., 269, 1994

1DRK

PROBING PROTEIN-PROTEIN INTERACTIONS: THE RIBOSE-BINDING PROTEIN IN BACTERIAL TRANSPORT AND CHEMOTAXIS
分子名称:	D-RIBOSE-BINDING PROTEIN, beta-D-ribopyranose
著者	Mowbray, S.L, Bjorkman, A.J.
登録日	1994-09-23
公開日	1995-01-26
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Probing protein-protein interactions. The ribose-binding protein in bacterial transport and chemotaxis. J.Biol.Chem., 269, 1994

1BA2

D67R MUTANT OF D-RIBOSE-BINDING PROTEIN FROM ESCHERICHIA COLI
分子名称:	D-RIBOSE-BINDING PROTEIN
著者	Bjorkman, A.J, Mowbray, S.L.
登録日	1998-04-19
公開日	1998-07-15
最終更新日	2024-05-22
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Multiple open forms of ribose-binding protein trace the path of its conformational change. J.Mol.Biol., 279, 1998

3ZHX

Structure of Mycobacterium tuberculosis DXR in complex with a fosmidomycin analogue
分子名称:	1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, MANGANESE (II) ION, [(1S)-1-(3,4-dichlorophenyl)-3-[oxidanyl(phenylcarbonyl)amino]propyl]phosphonic acid
著者	Bjorkelid, C, Jansson, A.M, Bergfors, T, Unge, T, Mowbray, S.L, Jones, T.A.
登録日	2012-12-30
公開日	2013-10-09
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Dxr Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues. J.Med.Chem., 56, 2013

3ZI0

Structure of Mycobacterium tuberculosis DXR in complex with a fosmidomycin analogue
分子名称:	1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, MANGANESE (II) ION, [(1S)-1-(3,4-dichlorophenyl)-3-{hydroxy[2-(1H-1,2,4-triazol-1-ylmethyl)benzoyl]amino}propyl]phosphonic acid
著者	Bjorkelid, C, Jansson, A.M, Bergfors, T, Unge, T, Mowbray, S.L, Jones, T.A.
登録日	2012-12-30
公開日	2013-10-09
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Dxr Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues. J.Med.Chem., 56, 2013

3ZHY

Structure of Mycobacterium tuberculosis DXR in complex with a di- substituted fosmidomycin analogue
分子名称:	1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, MANGANESE (II) ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者	Bjorkelid, C, Jansson, A.M, Bergfors, T, Unge, T, Mowbray, S.L, Jones, T.A.
登録日	2012-12-30
公開日	2013-10-09
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Dxr Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues. J.Med.Chem., 56, 2013

3ZHZ

Structure of Mycobacterium tuberculosis DXR in complex with a fosmidomycin analogue
分子名称:	1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, [(1S)-1-(3,4-dichlorophenyl)-3-[oxidanyl-[2-[[3-(trifluoromethyl)phenyl]amino]phenyl]carbonyl-amino]propyl]phosphonic acid
著者	Bjorkelid, C, Jansson, A.M, Bergfors, T, Unge, T, Mowbray, S.L, Jones, T.A.
登録日	2012-12-30
公開日	2013-10-09
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (2.25 Å)
主引用文献	Dxr Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues. J.Med.Chem., 56, 2013

1GCA

THE 1.7 ANGSTROMS REFINED X-RAY STRUCTURE OF THE PERIPLASMIC GLUCOSE(SLASH)GALACTOSE RECEPTOR FROM SALMONELLA TYPHIMURIUM
分子名称:	CALCIUM ION, GLUCOSE/GALACTOSE-BINDING PROTEIN, beta-D-galactopyranose
著者	Zou, J.-Y, Mowbray, S.L.
登録日	1993-05-13
公開日	1993-10-31
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	The 1.7 A refined X-ray structure of the periplasmic glucose/galactose receptor from Salmonella typhimurium. J.Mol.Biol., 233, 1993

1GCG

THE 1.9 ANGSTROMS X-RAY STRUCTURE OF A CLOSED UNLIGANDED FORM OF THE PERIPLASMIC GLUCOSE(SLASH)GALACTOSE RECEPTOR FROM SALMONELLA TYPHIMURIUM
分子名称:	CALCIUM ION, GALACTOSE/GLUCOSE-BINDING PROTEIN
著者	Flocco, M.M, Mowbray, S.L.
登録日	1994-02-03
公開日	1994-05-31
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	The 1.9 A x-ray structure of a closed unliganded form of the periplasmic glucose/galactose receptor from Salmonella typhimurium. J.Biol.Chem., 269, 1994

8QK2

Structure of K.pneumoniae LpxH in complex with EBL-3339
分子名称:	MANGANESE (II) ION, UDP-2,3-diacylglucosamine hydrolase, ~{N}-[4-[4-(4-cyano-6-methyl-pyrimidin-2-yl)piperazin-1-yl]sulfonylphenyl]-2-[methyl(methylsulfonyl)amino]benzamide
著者	Sooriyaarachchi, S, Bergfors, T, Jones, T.A, Mowbray, S.L.
登録日	2023-09-14
公開日	2024-04-17
実験手法	X-RAY DIFFRACTION (1.95 Å)
主引用文献	Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria. Proc.Natl.Acad.Sci.USA, 121, 2024

8QK5

Structure of K. pneumoniae LpxH in complex with EBL-3647
分子名称:	5-[[3-(aminomethyl)azetidin-1-yl]methyl]-N-[4-[4-(4-cyano-6-methyl-pyrimidin-2-yl)piperazin-1-yl]sulfonylphenyl]-2-[methyl(methylsulfonyl)amino]benzamide, MANGANESE (II) ION, UDP-2,3-diacylglucosamine hydrolase
著者	Sooriyaarachchi, S, Bergfors, T, Jones, T.A, Mowbray, S.L.
登録日	2023-09-14
公開日	2024-04-17
実験手法	X-RAY DIFFRACTION (1.95 Å)
主引用文献	Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria. Proc.Natl.Acad.Sci.USA, 121, 2024

8QK9

Structure of E. coli LpxH in complex with JEDI-1444
分子名称:	2-[methyl(methylsulfonyl)amino]-~{N}-[4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]sulfonylphenyl]benzamide, MANGANESE (II) ION, UDP-2,3-diacylglucosamine hydrolase
著者	Sooriyaarachchi, S, Bergfors, T, Jones, T.A, Mowbray, S.L.
登録日	2023-09-14
公開日	2024-04-17
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria. Proc.Natl.Acad.Sci.USA, 121, 2024

8QKA

Structure of K. pneumoniae LpxH in complex with JEDI-852
分子名称:	2-[methyl(methylsulfonyl)amino]-~{N}-(4-piperidin-1-ylsulfonylphenyl)benzamide, MANGANESE (II) ION, UDP-2,3-diacylglucosamine hydrolase
著者	Sooriyaarachchi, S, Bergfors, T, Jones, T.A, Mowbray, S.L.
登録日	2023-09-14
公開日	2024-04-17
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria. Proc.Natl.Acad.Sci.USA, 121, 2024

8QJZ

Crystal structure of E. coli LpxH in complex with lipid X
分子名称:	(R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, MANGANESE (II) ION, UDP-2,3-diacylglucosamine hydrolase
著者	Sooriyaarachchi, S, Bergfors, T, Jones, T.A, Mowbray, S.L.
登録日	2023-09-14
公開日	2024-04-17
実験手法	X-RAY DIFFRACTION (1.35 Å)
主引用文献	Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria. Proc.Natl.Acad.Sci.USA, 121, 2024

1URP

D-RIBOSE-BINDING PROTEIN FROM ESCHERICHIA COLI
分子名称:	D-RIBOSE-BINDING PROTEIN
著者	Bjorkman, A.J, Mowbray, S.L.
登録日	1998-04-03
公開日	1998-06-17
最終更新日	2024-04-03
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Multiple open forms of ribose-binding protein trace the path of its conformational change. J.Mol.Biol., 279, 1998

3ZXR

Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with tri-substituted imidazole inhibitor (3-(2-tert-butyl- 5-(pyridin-4-yl)-1H-imidazol-4-yl)quinoline) and L-methionine-S- sulfoximine phosphate.
分子名称:	3-(2-TERT-BUTYL-5-(PYRIDIN-4-YL)-1H-IMIDAZOL-4-YL)QUINOLINE, CHLORIDE ION, GLUTAMINE SYNTHETASE 1, ...
著者	Nilsson, M.T, Mowbray, S.L.
登録日	2011-08-15
公開日	2012-04-04
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (2.15 Å)
主引用文献	Trisubstituted Imidazoles as Mycobacterium Tuberculosis Glutamine Synthetase Inhibitors. J.Med.Chem., 55, 2012

3ZXV

Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with tri-substituted imidazole inhibitor (4-(2-tert-butyl- 4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl)pyridin-2-amine) and L- methionine-S-sulfoximine phosphate
分子名称:	4-(2-TERT-BUTYL-4-(6-METHOXYNAPHTHALEN-2-YL)-3H-IMIDAZOL-4-YL)PYRIDIN-2-AMINE, CHLORIDE ION, GLUTAMINE SYNTHETASE 1, ...
著者	Nilsson, M.T, Mowbray, S.L.
登録日	2011-08-16
公開日	2012-04-04
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (2.26 Å)
主引用文献	Trisubstituted Imidazoles as Mycobacterium Tuberculosis Glutamine Synthetase Inhibitors. J.Med.Chem., 55, 2012

4ACF

CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE IN COMPLEX WITH IMIDAZOPYRIDINE INHIBITOR ((4-(6-BROMO-3-(BUTYLAMINO)IMIDAZO(1,2-A)PYRIDIN-2-YL)PHENOXY) ACETIC ACID) AND L-METHIONINE-S-SULFOXIMINE PHOSPHATE.
分子名称:	CHLORIDE ION, GLUTAMINE SYNTHETASE 1, L-METHIONINE-S-SULFOXIMINE PHOSPHATE, ...
著者	Nilsson, M.T, Mowbray, S.L.
登録日	2011-12-15
公開日	2012-10-24
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Synthesis, Biological Evaluation and X-Ray Crystallographic Studies of Imidazo(1,2-A)Pyridine-Based Mycobacterium Tuberculosis Glutamine Synthetase Inhibitors Medchemcomm, 3, 2012

1GQT

Activation of Ribokinase by Monovalent Cations
分子名称:	CESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, RIBOKINASE, ...
著者	Andersson, C.E, Mowbray, S.L.
登録日	2001-12-05
公開日	2002-01-28
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (2.34 Å)
主引用文献	Activation of Ribokinase by Monovalent Cations. J.Mol.Biol., 315, 2002

5JO0

Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, LC56 and manganese
分子名称:	1,2-ETHANEDIOL, 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic, ...
著者	Sooriyaarachchi, S, Bergfors, T, Jones, T.A, Mowbray, S.L.
登録日	2016-05-01
公開日	2016-08-24
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with beta-Arylpropyl Analogues of Fosmidomycin. Chemmedchem, 11, 2016

5JBI

Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, LC52 and manganese
分子名称:	1,2-ETHANEDIOL, 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic, ...
著者	Sooriyaarachchi, S, Bergfors, T, Jones, T.A, Mowbray, S.L.
登録日	2016-04-13
公開日	2016-08-24
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with beta-Arylpropyl Analogues of Fosmidomycin. Chemmedchem, 11, 2016

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