5KVL
 
 | | Humanized 10G4 anti-leukotriene C4 antibody Fab fragment in complex with leukotriene C4 | | 分子名称: | (5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-[[(4~{S})-4-azanyl-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]-3-( 2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid, 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | 著者 | Huxford, T, King, A, Fleming, J.K, Wojciak, J.M. | | 登録日 | 2016-07-14 | | 公開日 | 2017-05-24 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Humanized 10G4 anti-leukotriene C4 antibody Fab fragment in complex with leukotriene C4
To Be Published
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1IKN
 | | IKAPPABALPHA/NF-KAPPAB COMPLEX | | 分子名称: | PROTEIN (I-KAPPA-B-ALPHA), PROTEIN (NF-KAPPA-B P50D SUBUNIT), PROTEIN (NF-KAPPA-B P65 SUBUNIT) | | 著者 | Huxford, T, Huang, D.-B, Malek, S, Ghosh, G. | | 登録日 | 1998-11-13 | | 公開日 | 1999-04-12 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation.
Cell(Cambridge,Mass.), 95, 1998
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1MY5
 | | NF-kappaB p65 subunit dimerization domain homodimer | | 分子名称: | NF-kappaB p65 (RelA) subunit | | 著者 | Huxford, T, Mishler, D, Phelps, C.B, Huang, D.-B, Sengchanthalangsy, L.L, Reeves, R, Hughes, C.A, Komives, E.A, Ghosh, G. | | 登録日 | 2002-10-03 | | 公開日 | 2002-12-04 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Solvent exposed non-contacting amino acids play a critical role in NF-kappaB/I kappaB alpha complex formation
J.Mol.Biol., 324, 2002
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1MY7
 | | NF-kappaB p65 subunit dimerization domain homodimer N202R mutation | | 分子名称: | NF-kappaB p65 (RelA) subunit | | 著者 | Huxford, T, Mishler, D, Phelps, C.B, Huang, D.-B, Sengchanthalangsy, L.L, Reeves, R, Hughes, C.A, Komives, E.A, Ghosh, G. | | 登録日 | 2002-10-03 | | 公開日 | 2002-12-04 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | Solvent exposed non-contacting amino acids play a critical role in NF-kappaB/IkappaB alpha complex formation
J.Mol.Biol., 324, 2002
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3I9G
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6NL6
 | | Crystal structure of mutant B1 immunoglobulin-binding domain of Streptococcal Protein G (T16F, T18A, V21E, T25L, K28Y, V29I, K31R, Q32H, Y33L, N35K, D36H, N37Q) | | 分子名称: | CHLORIDE ION, Immunoglobulin G-binding protein G, ZINC ION | | 著者 | Huxford, T, Stec, B, Maniaci, B. | | 登録日 | 2019-01-08 | | 公開日 | 2019-01-23 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Design of High-Affinity Metal-Controlled Protein Dimers.
Biochemistry, 58, 2019
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2BYR
 | | CRYSTAL STRUCTURE OF ACHBP FROM APLYSIA CALIFORNICA in complex with methyllycaconitine | | 分子名称: | ACETYLCHOLINE-BINDING PROTEIN, METHYLLYCACONITINE | | 著者 | Hansen, S.B, Sulzenbacher, G, Huxford, T, Marchot, P, Taylor, P, Bourne, Y. | | 登録日 | 2005-08-03 | | 公開日 | 2005-10-05 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Structures of Aplysia Achbp Complexes with Nicotinic Agonists and Antagonists Reveal Distinctive Binding Interfaces and Conformations.
Embo J., 24, 2005
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8EXW
 | | Drosophila melanogaster indirect flight muscle myosin II (subfragment-1) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Isoform K of Myosin heavy chain, muscle, ... | | 著者 | Caldwell, J.T, Huxford, T, Bernstein, S.I, Stec, B. | | 登録日 | 2022-10-25 | | 公開日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Drosophila melanogaster indirect flight muscle myosin II (subfragment-1)
To Be Published
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9BOR
 | | IkappaBzeta ankyrin repeat domain:NF-kappaB p50 homodimer complex at 2.0 Angstrom resolution | | 分子名称: | (2R,3S)-heptane-1,2,3-triol, NF-kappa-B inhibitor zeta, Nuclear factor NF-kappa-B p50 subunit | | 著者 | Rogers, W.E, Zhu, N, Huxford, T. | | 登録日 | 2024-05-05 | | 公開日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | | 主引用文献 | Structural and biochemical analyses of the nuclear I kappa B zeta protein in complex with the NF-kappa B p50 homodimer.
Genes Dev., 38, 2024
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6VRT
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1OY3
 | | CRYSTAL STRUCTURE OF AN IKBBETA/NF-KB P65 HOMODIMER COMPLEX | | 分子名称: | Transcription factor p65, transcription factor inhibitor I-kappa-B-beta | | 著者 | Malek, S, Huang, D.B, Huxford, T, Ghosh, S, Ghosh, G. | | 登録日 | 2003-04-03 | | 公開日 | 2003-05-20 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex.
J.Biol.Chem., 278, 2003
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6NL9
 | | Crystal structure of de novo designed metal-controlled dimer of mutant B1 immunoglobulin-binding domain of Streptococcal Protein G (L12H, T16L, V29H, Y33H, N37L)-apo | | 分子名称: | Immunoglobulin G-binding protein G, MAGNESIUM ION, SODIUM ION | | 著者 | Maniaci, B, Stec, B, Huxford, T. | | 登録日 | 2019-01-08 | | 公開日 | 2019-01-23 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Design of High-Affinity Metal-Controlled Protein Dimers.
Biochemistry, 58, 2019
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5W1A
 | | The first X-ray crystal structure of an insect muscle myosin. Drosophila melanogaster, skeletal muscle myosin II, an embryonic isoform, subfragment-1 | | 分子名称: | 1,2-ETHANEDIOL, CITRATE ANION, GLYCEROL, ... | | 著者 | Caldwell, J.T, Bernstein, S.I, Huxford, T. | | 登録日 | 2017-06-02 | | 公開日 | 2018-06-06 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.227 Å) | | 主引用文献 | X-ray crystallographic and molecular dynamic analyses of Drosophila melanogaster embryonic muscle myosin define domains responsible for isoform-specific properties.
J.Mol.Biol., 2019
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4ZF8
 | | Cytochrome P450 pentamutant from BM3 with bound Metyrapone | | 分子名称: | Bifunctional P-450/NADPH-P450 reductase, METYRAPONE, NICKEL (II) ION, ... | | 著者 | Rogers, W.E, Othman, T, Heidary, D.K, Huxford, T. | | 登録日 | 2015-04-21 | | 公開日 | 2016-07-13 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.766 Å) | | 主引用文献 | Effect of Mutation and Substrate Binding on the Stability of Cytochrome P450BM3 Variants.
Biochemistry, 55, 2016
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4ZFA
 | | Cytochrome P450 wild type from BM3 with bound PEG | | 分子名称: | 1,2-ETHANEDIOL, Bifunctional P-450/NADPH-P450 reductase, NICKEL (II) ION, ... | | 著者 | Rogers, W.E, Othman, T, Heidary, D.K, Huxford, T. | | 登録日 | 2015-04-21 | | 公開日 | 2016-07-13 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.765 Å) | | 主引用文献 | Effect of Mutation and Substrate Binding on the Stability of Cytochrome P450BM3 Variants.
Biochemistry, 55, 2016
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4ZFB
 | | Cytochrome P450 pentamutant from BM3 bound to Palmitic Acid | | 分子名称: | 1,2-ETHANEDIOL, Bifunctional P-450/NADPH-P450 reductase, NICKEL (II) ION, ... | | 著者 | Rogers, W.E, Othman, T, Heidary, D.K, Huxford, T. | | 登録日 | 2015-04-21 | | 公開日 | 2016-07-13 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | | 主引用文献 | Effect of Mutation and Substrate Binding on the Stability of Cytochrome P450BM3 Variants.
Biochemistry, 55, 2016
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4ZF6
 | | Cytochrome P450 pentamutant from BM3 with bound PEG | | 分子名称: | 1,2-ETHANEDIOL, Bifunctional P-450/NADPH-P450 reductase, NICKEL (II) ION, ... | | 著者 | Rogers, W.E, Othman, T, Heidary, D.K, Huxford, T. | | 登録日 | 2015-04-21 | | 公開日 | 2016-07-13 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.773 Å) | | 主引用文献 | Effect of Mutation and Substrate Binding on the Stability of Cytochrome P450BM3 Variants.
Biochemistry, 55, 2016
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3QCT
 | | Crystal structure of the humanized apo LT3015 anti-lysophosphatidic acid antibody Fab fragment | | 分子名称: | LT3015 antibody Fab fragment, heavy chain, light chain, ... | | 著者 | Fleming, J.K, Wojciak, J.M, Campbell, M.-A, Huxford, T. | | 登録日 | 2011-01-17 | | 公開日 | 2011-03-30 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.1493 Å) | | 主引用文献 | Biochemical and structural characterization of lysophosphatidic Acid binding by a humanized monoclonal antibody.
J.Mol.Biol., 408, 2011
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3QCV
 | | Crystal structure of the LT3015 antibody Fab fragment in complex with lysophosphatidic acid (18:2) | | 分子名称: | (2R)-2-hydroxy-3-(phosphonooxy)propyl (9Z,12Z)-octadeca-9,12-dienoate, LT3015 antibody Fab fragment, heavy chain, ... | | 著者 | Fleming, J.K, Wojciak, J.M, Campbell, M.-A, Huxford, T. | | 登録日 | 2011-01-17 | | 公開日 | 2011-03-30 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | | 主引用文献 | Biochemical and structural characterization of lysophosphatidic Acid binding by a humanized monoclonal antibody.
J.Mol.Biol., 408, 2011
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3NOW
 | | UNC-45 from Drosophila melanogaster | | 分子名称: | UNC-45 protein, SD10334p | | 著者 | Lee, C.F, Hauenstein, A.V, Fleming, J.K, Gasper, W.C, Engelke, V, Banumathi, S, Bernstein, S.I, Huxford, T. | | 登録日 | 2010-06-25 | | 公開日 | 2011-03-16 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.992 Å) | | 主引用文献 | X-ray Crystal Structure of the UCS Domain-Containing UNC-45 Myosin Chaperone from Drosophila melanogaster.
Structure, 19, 2011
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3PEO
 | | Crystal structure of acetylcholine binding protein complexed with metocurine | | 分子名称: | 6,6',7',12'-tetramethoxy-2,2,2',2'-tetramethyltubocuraran-2,2'-diium, Soluble acetylcholine receptor | | 著者 | Talley, T.T, Harel, M, Yamauchi, G.J, Radic, Z, Hansen, S, Huxford, T, Taylor, P.W. | | 登録日 | 2010-10-27 | | 公開日 | 2011-10-12 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The curare alkaloids: analyzing the poses of complexes with the acetylcholine binding protein in relation to structure and binding energetics
To be Published
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3PMZ
 | | Crystal Structure of the Complex of Acetylcholine Binding Protein and d-tubocurarine | | 分子名称: | (1beta,1'alpha)-7',12'-dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyltubocuraran-2'-ium, MAGNESIUM ION, Soluble acetylcholine receptor | | 著者 | Talley, T.T, Harel, M, Yamauchi, J.G, Radic, Z, Hansen, S, Huxford, T, Taylor, P.W. | | 登録日 | 2010-11-18 | | 公開日 | 2011-10-05 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | The Curare Alkaloids: Analyzing the Poses of Complexes with the Acetylcholine Binding Protein in Relation to Structure and Binding Energies
To be Published
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3QCU
 | | Crystal structure of the LT3015 antibody Fab fragment in complex with lysophosphatidic acid (14:0) | | 分子名称: | (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, LT3015 antibody Fab fragment, heavy chain, ... | | 著者 | Fleming, J.K, Wojciak, J.M, Campbell, M.-A, Huxford, T. | | 登録日 | 2011-01-17 | | 公開日 | 2011-03-30 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.979 Å) | | 主引用文献 | Biochemical and structural characterization of lysophosphatidic Acid binding by a humanized monoclonal antibody.
J.Mol.Biol., 408, 2011
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1BFT
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1BFS
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