1W5S
 
 | | Structure of the Aeropyrum Pernix ORC2 protein (ADP form) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ORIGIN RECOGNITION COMPLEX SUBUNIT 2 ORC2, SULFATE ION | | 著者 | Singleton, M.R, Morales, R, Grainge, I, Cook, N, Isupov, M.N, Wigley, D.B. | | 登録日 | 2004-08-09 | | 公開日 | 2004-10-05 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Conformational Changes Induced by Nucleotide Binding in Cdc6/Orc from Aeropyrum Pernix
J.Mol.Biol., 343, 2004
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1W5T
 | | Structure of the Aeropyrum Pernix ORC2 protein (ADPNP-ADP complexes) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ORC2, ... | | 著者 | Singleton, M.R, Morales, R, Grainge, I, Cook, N, Isupov, M.N, Wigley, D.B. | | 登録日 | 2004-08-09 | | 公開日 | 2004-10-05 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Conformational Changes Induced by Nucleotide Binding in Cdc6/Orc from Aeropyrum Pernix
J.Mol.Biol., 343, 2004
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2UUZ
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2UV1
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3E1S
 | | Structure of an N-terminal truncation of Deinococcus radiodurans RecD2 | | 分子名称: | Exodeoxyribonuclease V, subunit RecD | | 著者 | Saikrishnan, K, Griffiths, S.P, Cook, N, Court, R, Wigley, D.B. | | 登録日 | 2008-08-04 | | 公開日 | 2008-08-19 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | DNA binding to RecD: role of the 1B domain in SF1B helicase activity.
Embo J., 27, 2008
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2CHV
 | | Replication Factor C ADPNP complex | | 分子名称: | REPLICATION FACTOR C SMALL SUBUNIT | | 著者 | Seybert, A, Singleton, M.R, Cook, N, Hall, D.R, Wigley, D.B. | | 登録日 | 2006-03-16 | | 公開日 | 2006-06-06 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (4 Å) | | 主引用文献 | Communication between Subunits within an Archaeal Clamp-Loader Complex.
Embo J., 25, 2006
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2CHG
 | | Replication Factor C domains 1 and 2 | | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, REPLICATION FACTOR C SMALL SUBUNIT | | 著者 | Seybert, A, Singleton, M.R, Cook, N, Hall, D.R, Wigley, D.B. | | 登録日 | 2006-03-14 | | 公開日 | 2006-06-06 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Communication between Subunits within an Archaeal Clamp-Loader Complex.
Embo J., 25, 2006
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2CHQ
 | | Replication Factor C ADPNP complex | | 分子名称: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, REPLICATION FACTOR C SMALL SUBUNIT | | 著者 | Seybert, A, Singleton, M.R, Cook, N, Hall, D.R, Wigley, D.B. | | 登録日 | 2006-03-16 | | 公開日 | 2006-06-06 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Communication between Subunits within an Archaeal Clamp-Loader Complex.
Embo J., 25, 2006
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3GPL
 | | Crystal structure of the ternary complex of RecD2 with DNA and ADPNP | | 分子名称: | 5'-D(*T*TP*TP*TP*TP*TP*TP*T)-3', Exodeoxyribonuclease V, subunit RecD, ... | | 著者 | Saikrishnan, K, Cook, N, Wigley, D.B. | | 登録日 | 2009-03-23 | | 公開日 | 2009-06-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Mechanistic basis of 5'-3' translocation in SF1B helicases.
Cell(Cambridge,Mass.), 137, 2009
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3GP8
 | | Crystal structure of the binary complex of RecD2 with DNA | | 分子名称: | 5'-D(*TP*TP*TP*TP*TP*T*TP*TP*TP*TP*TP*TP*TP*T)-3', Exodeoxyribonuclease V, subunit RecD, ... | | 著者 | Saikrishnan, K, Cook, N, Wigley, D.B. | | 登録日 | 2009-03-23 | | 公開日 | 2009-06-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Mechanistic basis of 5'-3' translocation in SF1B helicases.
Cell(Cambridge,Mass.), 137, 2009
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5CZ2
 | | Crystal structure of a two-domain fragment of MMTV integrase | | 分子名称: | MAGNESIUM ION, Pol polyprotein, ZINC ION | | 著者 | Cook, N, Ballandras-Colas, A, Engelman, A, Cherepanov, P. | | 登録日 | 2015-07-31 | | 公開日 | 2016-02-17 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | | 主引用文献 | Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.
Nature, 530, 2016
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5CZ1
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6GX9
 | | Crystal structure of the TNPO3 - CPSF6 RSLD complex | | 分子名称: | BENZAMIDINE, BICINE, Cleavage and polyadenylation specificity factor subunit 6, ... | | 著者 | Cherepanov, P, Cook, N. | | 登録日 | 2018-06-26 | | 公開日 | 2019-03-13 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6.
Nucleic Acids Res., 47, 2019
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6RWO
 | | SIVrcm intasome (Q148H/G140S) in complex with bictegravir | | 分子名称: | Bictegravir, CHLORIDE ION, DNA (5'-D(*AP*AP*CP*TP*GP*GP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*TP*CP*TP*TP*AP*GP*C)-3'), ... | | 著者 | Cherepanov, P, Nans, A, Cook, N. | | 登録日 | 2019-06-05 | | 公開日 | 2020-02-05 | | 最終更新日 | 2022-03-30 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Structural basis of second-generation HIV integrase inhibitor action and viral resistance.
Science, 367, 2020
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6RWL
 | | SIVrcm intasome | | 分子名称: | DNA (5'-D(*AP*AP*CP*TP*GP*GP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*TP*CP*TP*TP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*AP*AP*GP*AP*AP*AP*AP*AP*TP*CP*TP*CP*TP*AP*CP*CP*A)-3'), Pol protein, ... | | 著者 | Cherepanov, P, Nans, A, Cook, N. | | 登録日 | 2019-06-05 | | 公開日 | 2020-02-05 | | 最終更新日 | 2022-03-30 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | Structural basis of second-generation HIV integrase inhibitor action and viral resistance.
Science, 367, 2020
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6RWN
 | | SIVrcm intasome in complex with dolutegravir | | 分子名称: | (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, CHLORIDE ION, DNA (5'-D(*AP*AP*CP*TP*GP*GP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*TP*CP*TP*TP*AP*GP*C)-3'), ... | | 著者 | Cherepanov, P, Nans, A, Cook, N. | | 登録日 | 2019-06-05 | | 公開日 | 2020-02-05 | | 最終更新日 | 2022-03-30 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis of second-generation HIV integrase inhibitor action and viral resistance.
Science, 367, 2020
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6RWM
 | | SIVrcm intasome in complex with bictegravir | | 分子名称: | Bictegravir, CHLORIDE ION, DNA (5'-D(*AP*AP*CP*TP*GP*GP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*TP*CP*TP*TP*AP*GP*C)-3'), ... | | 著者 | Cherepanov, P, Nans, A, Cook, N. | | 登録日 | 2019-06-05 | | 公開日 | 2020-02-05 | | 最終更新日 | 2022-03-30 | | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | | 主引用文献 | Structural basis of second-generation HIV integrase inhibitor action and viral resistance.
Science, 367, 2020
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3IW4
 | | Crystal structure of PKC alpha in complex with NVP-AEB071 | | 分子名称: | 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]-1H-pyrrole-2,5-dione, Protein kinase C alpha type | | 著者 | Stark, W, Rummel, G, Strauss, A, Cowan-Jacob, S.W. | | 登録日 | 2009-09-02 | | 公開日 | 2009-11-03 | | 最終更新日 | 2021-11-10 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes
J.Med.Chem., 52, 2009
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3K70
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