2MF2
 
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4MZM
 | | MazF from S. aureus crystal form I, P212121, 2.1 A | | 分子名称: | mRNA interferase MazF | | 著者 | Zorzini, V, Loris, R, van Nuland, N.A.J, Cheung, A. | | 登録日 | 2013-09-30 | | 公開日 | 2014-05-28 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural and biophysical characterization of Staphylococcus aureus SaMazF shows conservation of functional dynamics.
Nucleic Acids Res., 42, 2014
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4MZP
 | | MazF from S. aureus crystal form III, C2221, 2.7 A | | 分子名称: | MazF mRNA interferase | | 著者 | Zorzini, V, Loris, R, van Nuland, N.A.J, Cheung, A. | | 登録日 | 2013-09-30 | | 公開日 | 2014-05-21 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.702 Å) | | 主引用文献 | Structural and biophysical characterization of Staphylococcus aureus SaMazF shows conservation of functional dynamics.
Nucleic Acids Res., 42, 2014
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4MZT
 | | MazF from S. aureus crystal form II, C2221, 2.3 A | | 分子名称: | MazF mRNA interferase | | 著者 | Zorzini, V, Loris, R, van Nuland, N.A.J, Cheung, A. | | 登録日 | 2013-09-30 | | 公開日 | 2014-05-21 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.303 Å) | | 主引用文献 | Structural and biophysical characterization of Staphylococcus aureus SaMazF shows conservation of functional dynamics.
Nucleic Acids Res., 42, 2014
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6HV9
 | | S. cerevisiae CMG-Pol epsilon-DNA | | 分子名称: | Cell division control protein 45, DNA (5'-D(*GP*CP*AP*GP*CP*CP*AP*CP*GP*CP*TP*GP*GP*CP*CP*GP*TP*TP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*AP*AP*CP*GP*GP*CP*CP*AP*GP*CP*GP*TP*GP*GP*CP*TP*GP*C)-3'), ... | | 著者 | Abid Ali, F, Purkiss, A.G, Cheung, A, Costa, A. | | 登録日 | 2018-10-10 | | 公開日 | 2018-12-12 | | 最終更新日 | 2023-07-05 | | 実験手法 | ELECTRON MICROSCOPY (4.98 Å) | | 主引用文献 | Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome.
Nat Commun, 9, 2018
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6HV8
 | | Cryo-EM structure of S. cerevisiae Polymerase epsilon deltacat mutant | | 分子名称: | DNA polymerase epsilon catalytic subunit A, DNA polymerase epsilon subunit B, ZINC ION | | 著者 | Goswami, P, Purkiss, A, Cheung, A, Costa, A. | | 登録日 | 2018-10-10 | | 公開日 | 2018-12-12 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome.
Nat Commun, 9, 2018
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6T9K
 | | SAGA Core module | | 分子名称: | Protein SPT3, SAGA-associated factor 73, Transcription factor SPT20, ... | | 著者 | Wang, H, Cheung, A, Cramer, P. | | 登録日 | 2019-10-28 | | 公開日 | 2020-01-29 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure of the transcription coactivator SAGA.
Nature, 577, 2020
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6T9J
 | | SAGA Tra1 module | | 分子名称: | Transcription factor SPT20, Transcription initiation factor TFIID subunit 12, Transcription-associated protein 1 | | 著者 | Wang, H, Cheung, A, Cramer, P. | | 登録日 | 2019-10-28 | | 公開日 | 2020-01-29 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structure of the transcription coactivator SAGA.
Nature, 577, 2020
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6T9I
 | | cryo-EM structure of transcription coactivator SAGA | | 分子名称: | Protein SPT3, SAGA-associated factor 73, Transcription factor SPT20, ... | | 著者 | Wang, H, Cheung, A, Cramer, P. | | 登録日 | 2019-10-28 | | 公開日 | 2020-01-29 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structure of the transcription coactivator SAGA.
Nature, 577, 2020
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4BOC
 | | Structure of mitochondrial RNA polymerase elongation complex | | 分子名称: | 5'-D(*CP*AP*TP*GP*GP*GP*GP*TP*AP*AP*TP*TP*AP*TP *TP*TP*CP*GP*AP*CP*GP*CP*CP*AP*GP*AP*CP*G)-3', 5'-D(*CP*GP*TP*CP*TP*GP*GP*CP*GP*TP*GP*CP*GP*CP *GP*CP*CP*GP*CP*TP*AP*CP*CP*CP*CP*AP*TP*G)-3', 5'-R(*AP*GP*UP*CP*UP*GP*CP*GP*GP*CP*GP*CP*GP*CP)-3', ... | | 著者 | Schwinghammer, K, Cheung, A, Morozov, Y, Agaronyan, K, Temiakov, D, Cramer, P. | | 登録日 | 2013-05-18 | | 公開日 | 2013-09-25 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Structure of Human Mitochondrial RNA Polymerase Elongation Complex
Nat.Struct.Mol.Biol., 20, 2013
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7LUN
 | | Human PARP14 (ARTD8), catalytic fragment in complex with RBN011980 | | 分子名称: | 7-(cyclopentylamino)-5-fluoro-2-{[(trans-4-hydroxycyclohexyl)sulfanyl]methyl}quinazolin-4(3H)-one, CHLORIDE ION, GLYCEROL, ... | | 著者 | Dorsey, B.W, Swinger, K.K, Schenkel, L.B, Church, W.D, Perl, N.R, Vasbinder, M.M, Wigle, T.J, Kuntz, K.W. | | 登録日 | 2021-02-22 | | 公開日 | 2021-04-21 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule.
Chembiochem, 22, 2021
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3BRV
 | | NEMO/IKKb association domain structure | | 分子名称: | Inhibitor of nuclear factor kappa-B kinase subunit beta, NF-kappa-B essential modulator | | 著者 | Silvian, L.F. | | 登録日 | 2007-12-21 | | 公開日 | 2008-04-22 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure of a NEMO/IKK-Associating Domain Reveals Architecture of the Interaction Site.
Structure, 16, 2008
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7L9Y
 | | Human PARP14 (ARTD8), catalytic fragment in complex with RBN012042 | | 分子名称: | 1,2-ETHANEDIOL, 7-(cyclopentylamino)-5-fluoro-2-{[(piperidin-4-yl)sulfanyl]methyl}quinazolin-4(3H)-one, CHLORIDE ION, ... | | 著者 | Dorsey, B.W, Swinger, K.K, Schenkel, L.B, Church, W.D, Perl, N.R, Vasbinder, M.M, Wigle, T.J, Kuntz, K.W. | | 登録日 | 2021-01-05 | | 公開日 | 2021-04-21 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule.
Chembiochem, 22, 2021
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3BRT
 | | NEMO/IKK association domain structure | | 分子名称: | Inhibitor of nuclear factor kappa-B kinase subunit beta,Inhibitor of nuclear factor kappa-B kinase subunit alpha, NF-kappa-B essential modulator | | 著者 | Silvian, L.F. | | 登録日 | 2007-12-21 | | 公開日 | 2008-04-22 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structure of a NEMO/IKK-Associating Domain Reveals Architecture of the Interaction Site.
Structure, 16, 2008
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3UH4
 | | TANKYRASE-1 complexed with NVP-XAV939 | | 分子名称: | 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol, GLYCEROL, SULFATE ION, ... | | 著者 | Stams, T, Kirby, C. | | 登録日 | 2011-11-03 | | 公開日 | 2012-02-15 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939.
Acta Crystallogr.,Sect.F, 68, 2012
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3UH2
 | | Tankyrase-1 in complexed with PJ34 | | 分子名称: | N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE, SULFATE ION, Tankyrase-1, ... | | 著者 | Kirby, C.A, Stams, T. | | 登録日 | 2011-11-03 | | 公開日 | 2012-02-15 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939.
Acta Crystallogr.,Sect.F, 68, 2012
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3UDD
 | | Tankyrase-1 in complex with small molecule inhibitor | | 分子名称: | 3-(4-methoxyphenyl)-5-({[4-(4-methoxyphenyl)-5-methyl-4H-1,2,4-triazol-3-yl]sulfanyl}methyl)-1,2,4-oxadiazole, GLYCEROL, SULFATE ION, ... | | 著者 | Kirby, C.A, Stams, T. | | 登録日 | 2011-10-28 | | 公開日 | 2012-02-01 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | [1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding.
J.Med.Chem., 55, 2012
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