7LUN

Human PARP14 (ARTD8), catalytic fragment in complex with RBN011980

Summary for 7LUN

• Entry DOI: 10.2210/pdb7lun/pdb
• Descriptor: Protein mono-ADP-ribosyltransferase PARP14, 7-(cyclopentylamino)-5-fluoro-2-{[(trans-4-hydroxycyclohexyl)sulfanyl]methyl}quinazolin-4(3H)-one, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: parp14, artd8, monoparp, adp ribosylation, inhibitor complex, transferase-inhibitor complex, transferase, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 8
• Total formula weight: 180732.26

Authors

Dorsey, B.W.,Swinger, K.K.,Schenkel, L.B.,Church, W.D.,Perl, N.R.,Vasbinder, M.M.,Wigle, T.J.,Kuntz, K.W. (deposition date: 2021-02-22, release date: 2021-04-21, Last modification date: 2023-10-18)

• Primary citation: Wigle, T.J.,Ren, Y.,Molina, J.R.,Blackwell, D.J.,Schenkel, L.B.,Swinger, K.K.,Kuplast-Barr, K.,Majer, C.R.,Church, W.D.,Lu, A.Z.,Mo, J.,Abo, R.,Cheung, A.,Dorsey, B.W.,Niepel, M.,Perl, N.R.,Vasbinder, M.M.,Keilhack, H.,Kuntz, K.W.; Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule.; Chembiochem, 22:2107-2110, 2021; PubMed: 33838082; DOI: 10.1002/cbic.202100047

Experimental method

X-RAY DIFFRACTION (2.57 Å)