8TLE
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8TLF
| CDCA7 (Mouse) Binds Non-B-form DNA oligo 36-mer (sg C2-Form 2) | 分子名称: | 1,2-ETHANEDIOL, Cell division cycle-associated protein 7, GLYCEROL, ... | 著者 | Horton, J.R, Ren, R, Cheng, X. | 登録日 | 2023-07-26 | 公開日 | 2024-08-21 | 最終更新日 | 2024-08-28 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | The ICF syndrome protein CDCA7 harbors a unique DNA-binding domain that recognizes a CpG dyad in the context of a non-B DNA. Biorxiv, 2023
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8TLG
| CDCA7 (Mouse) Binds Non-B-form 34-mer DNA oligo | 分子名称: | 1,2-ETHANEDIOL, Cell division cycle-associated protein 7, DNA (34-MER), ... | 著者 | Horton, J.R, Ren, R, Cheng, X. | 登録日 | 2023-07-26 | 公開日 | 2024-08-21 | 最終更新日 | 2024-08-28 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | The ICF syndrome protein CDCA7 harbors a unique DNA-binding domain that recognizes a CpG dyad in the context of a non-B DNA. Biorxiv, 2023
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8TLH
| CDCA7 (Mouse) Binds Non-B-form 32-mer DNA oligo | 分子名称: | 1,2-ETHANEDIOL, Cell division cycle-associated protein 7, DNA (32-MER), ... | 著者 | Horton, J.R, Ren, R, Cheng, X. | 登録日 | 2023-07-26 | 公開日 | 2024-08-21 | 最終更新日 | 2024-08-28 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | The ICF syndrome protein CDCA7 harbors a unique DNA-binding domain that recognizes a CpG dyad in the context of a non-B DNA. Biorxiv, 2023
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6KSQ
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6A71
| Crystal Structure of Human ATP7B and TM Complex | 分子名称: | ATP7B protein, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Chen, W.B. | 登録日 | 2018-06-30 | 公開日 | 2019-04-03 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein. Nat Commun, 10, 2019
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7X9E
| Crystal structure of the 76E1 Fab in complex with a SARS-CoV-2 spike peptide | 分子名称: | 76E1 Fab Heavy Chain, 76E1 Fab Light Chain, Spike peptide | 著者 | Chen, X, Zhang, T, Ding, J, Sun, X, Sun, B. | 登録日 | 2022-03-15 | 公開日 | 2022-05-11 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Neutralization mechanism of a human antibody with pan-coronavirus reactivity including SARS-CoV-2. Nat Microbiol, 7, 2022
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7X6Z
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7X70
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7X6Y
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8KI5
| PhmA, a type I diterpene synthase without NST/DTE motif | 分子名称: | (2Z,6Z)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol, PhmA | 著者 | Zhang, B, Ge, H.M, Zhu, A, Zhang, Y. | 登録日 | 2023-08-22 | 公開日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Biosynthesis of Platelet Activating Factor Antagonist Phomactins Revealing a New Class of Type I Diterpene Synthase To Be Published
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8KIH
| PhmA, a type I diterpene synthase without NST/DTE motif | 分子名称: | (2Z,6E,10E)-2-fluoro-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl trihydrogen diphosphate, MAGNESIUM ION, diterpene synthase, ... | 著者 | Zhang, B, Ge, H.M, Zhu, A, Zhang, Y. | 登録日 | 2023-08-23 | 公開日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Biosynthesis of Platelet Activating Factor Antagonist Phomactins Revealing a New Class of Type I Diterpene Synthase To Be Published
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7E1F
| Native-DBD | 分子名称: | DNA-binding response regulator | 著者 | Hong, S, Zhang, P. | 登録日 | 2021-02-01 | 公開日 | 2022-02-09 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.447 Å) | 主引用文献 | Structural basis of phosphorylation-induced activation of the response regulator VbrR. Acta Biochim.Biophys.Sin., 2023
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7E1D
| Se-DBD | 分子名称: | DNA-binding response regulator | 著者 | Hong, S, Zhang, P. | 登録日 | 2021-02-01 | 公開日 | 2022-02-09 | 最終更新日 | 2023-02-22 | 実験手法 | X-RAY DIFFRACTION (2.002 Å) | 主引用文献 | Structural basis of phosphorylation-induced activation of the response regulator VbrR. Acta Biochim.Biophys.Sin., 2023
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6B1E
| The structure of DPP4 in complex with Vildagliptin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{[(1r,3s,5R,7S)-3-hydroxytricyclo[3.3.1.1~3,7~]decan-1-yl]amino}-1-{(2S)-2-[(E)-iminomethyl]pyrrolidin-1-yl}ethan-1-o ne, ... | 著者 | Scapin, G. | 登録日 | 2017-09-18 | 公開日 | 2017-09-27 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice. Endocrinol Diabetes Metab, 1, 2018
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6B1O
| The structure of DPP4 in complex with Vildagliptin Analog | 分子名称: | (2S)-2-amino-1-[(1S,3S,5S)-3-(aminomethyl)-2-azabicyclo[3.1.0]hexan-2-yl]-2-[(1r,3R,5S,7S)-3,5-dihydroxytricyclo[3.3.1.1~3,7~]decan-1-yl]ethan-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Scapin, G. | 登録日 | 2017-09-18 | 公開日 | 2017-09-27 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice. Endocrinol Diabetes Metab, 1, 2018
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8K3C
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6BEK
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7ECY
| EV-D68 in complex with 2H12 Fab (State 3) | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | 著者 | Xu, C, Cong, Y. | 登録日 | 2021-03-13 | 公開日 | 2021-03-31 | 最終更新日 | 2021-06-02 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections. Nat Commun, 12, 2021
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7EBZ
| EV-D68 in complex with 2H12 Fab (state S1) | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | 著者 | Xu, C, Cong, Y. | 登録日 | 2021-03-11 | 公開日 | 2021-03-31 | 最終更新日 | 2021-06-02 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections. Nat Commun, 12, 2021
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7EBR
| EV-D68 in complex with 2H12 Fab (state S2) | 分子名称: | 2H12 Fab heavy chain, 2H12 Fab light chain, Capsid protein VP1, ... | 著者 | Xu, C, Cong, Y. | 登録日 | 2021-03-10 | 公開日 | 2021-03-31 | 最終更新日 | 2021-06-02 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections. Nat Commun, 12, 2021
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7EC5
| EV-D68 in complex with 8F12 Fab | 分子名称: | 8F12 Fab heavy chain, 8F12 Fab light chain, Capsid protein VP1, ... | 著者 | Xu, C, Cong, Y. | 登録日 | 2021-03-11 | 公開日 | 2021-03-31 | 最終更新日 | 2021-06-02 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections. Nat Commun, 12, 2021
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4N0N
| Crystal structure of Arterivirus nonstructural protein 10 (helicase) | 分子名称: | MAGNESIUM ION, Replicase polyprotein 1ab, SULFATE ION, ... | 著者 | Deng, Z, Chen, Z. | 登録日 | 2013-10-02 | 公開日 | 2014-01-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase. Nucleic Acids Res., 42, 2014
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7JRN
| Crystal structure of the wild type SARS-CoV-2 papain-like protease (PLPro) with inhibitor GRL0617 | 分子名称: | 5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide, Non-structural protein 3, SULFATE ION, ... | 著者 | Sacco, M, Ma, C, Wang, J, Chen, Y. | 登録日 | 2020-08-12 | 公開日 | 2020-08-26 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Discovery of SARS-CoV-2 Papain-like Protease Inhibitors through a Combination of High-Throughput Screening and a FlipGFP-Based Reporter Assay. Acs Cent.Sci., 7, 2021
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6LWA
| Crystal structure of human NEIL1(P2G, E3Q, K242) bound to duplex DNA containing 5-hydroxyuracil (5-OHU) | 分子名称: | DNA (5'-D(*CP*GP*TP*CP*CP*AP*(OHU)P*GP*TP*CP*TP*AP*C)-3'), DNA (5'-D(*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*G)-3'), Endonuclease 8-like 1 | 著者 | Liu, M.H, Zhang, J, Zhu, C.X, Zhang, X.X, Gao, Y.Q, Yi, C.Q. | 登録日 | 2020-02-07 | 公開日 | 2021-06-09 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | 主引用文献 | DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes. Nat Commun, 12, 2021
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