6B1O

The structure of DPP4 in complex with Vildagliptin Analog

Summary for 6B1O

• Entry DOI: 10.2210/pdb6b1o/pdb
• Descriptor: Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: diabetes, dpp4 inhibitors, covalent inhibitors, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 174107.41

Authors

Scapin, G. (deposition date: 2017-09-18, release date: 2017-09-27, Last modification date: 2020-07-29)

• Primary citation: Berger, J.P.,SinhaRoy, R.,Pocai, A.,Kelly, T.M.,Scapin, G.,Gao, Y.D.,Pryor, K.A.D.,Wu, J.K.,Eiermann, G.J.,Xu, S.S.,Zhang, X.,Tatosian, D.A.,Weber, A.E.,Thornberry, N.A.,Carr, R.D.; A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice.; Endocrinol Diabetes Metab, 1:e00002-e00002, 2018; PubMed: 30815539; DOI: 10.1002/edm2.2

Experimental method

X-RAY DIFFRACTION (1.91 Å)