5E69
| Glucocorticoid receptor DNA binding domain - IL8 NF-kB response element complex | 分子名称: | DNA (5'-D(*AP*TP*CP*GP*TP*GP*GP*AP*AP*TP*TP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*AP*AP*TP*TP*CP*CP*AP*CP*GP*AP*T)-3'), Glucocorticoid receptor, ... | 著者 | Hudson, W.H, Rye, E.A, Herbst, A.G, Ortlund, E.A. | 登録日 | 2015-10-09 | 公開日 | 2017-02-08 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Cryptic glucocorticoid receptor-binding sites pervade genomic NF-kappa B response elements. Nat Commun, 9, 2018
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5E6D
| Glucocorticoid receptor DNA binding domain - ICAM1 NF-kB response element complex | 分子名称: | DNA (5'-D(*GP*CP*TP*CP*CP*GP*GP*AP*AP*TP*TP*TP*CP*CP*AP*A)-3'), DNA (5'-D(*TP*TP*GP*GP*AP*AP*AP*TP*TP*CP*CP*GP*GP*AP*GP*C)-3'), Glucocorticoid receptor, ... | 著者 | Hudson, W.H, Rye, E.A, Herbst, A.G, Ortlund, E.A. | 登録日 | 2015-10-09 | 公開日 | 2017-02-08 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Cryptic glucocorticoid receptor-binding sites pervade genomic NF-kappa B response elements. Nat Commun, 9, 2018
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8YP3
| Crystal structure of UDP-N-acetylglucosamine pyrophosphorylase from Spodoptera frugiperda in complex with UDP-GlcNAc | 分子名称: | MAGNESIUM ION, SULFATE ION, UDP-N-acetylglucosamine diphosphorylase, ... | 著者 | Lu, Q, Liu, T, Zhou, Y, Yang, Q. | 登録日 | 2024-03-15 | 公開日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Structure and Inhibition of Insect UDP- N -acetylglucosamine Pyrophosphorylase: A Key Enzyme in the Hexosamine Biosynthesis Pathway. J.Agric.Food Chem., 2024
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8V4U
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9AUK
| Structure of SARS-CoV-2 Mpro mutant (A173V) in complex with Nirmatrelvir (PF-07321332) | 分子名称: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | 著者 | Gajiwala, K.S, Greasley, S.E, Ferre, R.A, Liu, W, Stewart, A.E. | 登録日 | 2024-02-29 | 公開日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance. Sci Adv, 10, 2024
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9AUO
| Structure of SARS-CoV-2 Mpro mutant (L50F,T304I) | 分子名称: | 3C-like proteinase nsp5 | 著者 | Gajiwala, K.S, Greasley, S.E, Ferre, R.A, Liu, W, Stewart, A.E. | 登録日 | 2024-02-29 | 公開日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (2.423 Å) | 主引用文献 | In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance. Sci Adv, 10, 2024
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8XFB
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8Z9M
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9AUJ
| Structure of SARS-CoV-2 Mpro mutant (S144A) in complex with Nirmatrelvir (PF-07321332) | 分子名称: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | 著者 | Gajiwala, K.S, Greasley, S.E, Ferre, R.A, Liu, W, Stewart, A.E. | 登録日 | 2024-02-29 | 公開日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (1.486 Å) | 主引用文献 | In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance. Sci Adv, 10, 2024
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9AUM
| Structure of SARS-CoV-2 Mpro mutant (T21I,S144A,T304I) in complex with Nirmatrelvir (PF-07321332) | 分子名称: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | 著者 | Gajiwala, K.S, Greasley, S.E, Ferre, R.A, Liu, W, Stewart, A.E. | 登録日 | 2024-02-29 | 公開日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (1.539 Å) | 主引用文献 | In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance. Sci Adv, 10, 2024
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9AUN
| Structure of SARS-CoV-2 Mpro mutant (T21I,T304I) | 分子名称: | 3C-like proteinase nsp5 | 著者 | Gajiwala, K.S, Greasley, S.E, Ferre, R.A, Liu, W, Stewart, A.E. | 登録日 | 2024-02-29 | 公開日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance. Sci Adv, 10, 2024
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9AUL
| Structure of SARS-CoV-2 Mpro mutant (A173V,T304I)) in complex with Nirmatrelvir (PF-07321332) | 分子名称: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | 著者 | Gajiwala, K.S, Greasley, S.E, Ferre, R.A, Liu, W, Stewart, A.E. | 登録日 | 2024-02-29 | 公開日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (2.421 Å) | 主引用文献 | In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance. Sci Adv, 10, 2024
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4MPZ
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8HPM
| LpqY-SugABC in state 2 | 分子名称: | ABC sugar transporter, permease component, ABC transporter, ... | 著者 | Liang, J, Yang, X, Zhang, B, Rao, Z, Liu, F. | 登録日 | 2022-12-12 | 公開日 | 2023-09-06 | 最終更新日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (3.82 Å) | 主引用文献 | Structural insights into trehalose capture and translocation by mycobacterial LpqY-SugABC. Structure, 31, 2023
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8HPN
| LpqY-SugABC in state 3 | 分子名称: | ABC sugar transporter, permease component, ABC transporter, ... | 著者 | Liang, J, Yang, X, Zhang, B, Rao, Z, Liu, F. | 登録日 | 2022-12-12 | 公開日 | 2023-09-06 | 最終更新日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (4.55 Å) | 主引用文献 | Structural insights into trehalose capture and translocation by mycobacterial LpqY-SugABC. Structure, 31, 2023
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8HPS
| LpqY-SugABC in state 5 | 分子名称: | ABC sugar transporter, permease component, ABC transporter, ... | 著者 | Liang, J, Yang, X, Zhang, B, Rao, Z, Liu, F. | 登録日 | 2022-12-12 | 公開日 | 2023-09-06 | 最終更新日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (3.51 Å) | 主引用文献 | Structural insights into trehalose capture and translocation by mycobacterial LpqY-SugABC. Structure, 31, 2023
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8HPL
| LpqY-SugABC in state 1 | 分子名称: | ABC sugar transporter, permease component, ABC transporter, ... | 著者 | Liang, J, Yang, X, Zhang, B, Rao, Z, Liu, F. | 登録日 | 2022-12-12 | 公開日 | 2023-09-06 | 最終更新日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (4.29 Å) | 主引用文献 | Structural insights into trehalose capture and translocation by mycobacterial LpqY-SugABC. Structure, 31, 2023
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8HPR
| LpqY-SugABC in state 4 | 分子名称: | ABC sugar transporter, permease component, ABC transporter, ... | 著者 | Liang, J, Yang, X, Zhang, B, Rao, Z, Liu, F. | 登録日 | 2022-12-12 | 公開日 | 2023-09-06 | 最終更新日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (3.75 Å) | 主引用文献 | Structural insights into trehalose capture and translocation by mycobacterial LpqY-SugABC. Structure, 31, 2023
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8HEI
| Crystal structure of CTSB in complex with E64d | 分子名称: | Cathepsin B, GLYCEROL, ethyl (3S)-3-hydroxy-4-({(2S)-4-methyl-1-[(3-methylbutyl)amino]-1-oxopentan-2-yl}amino)-4-oxobutanoate | 著者 | Wang, H, Li, D, Sun, L, Yang, H. | 登録日 | 2022-11-08 | 公開日 | 2023-12-13 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry. Nat Commun, 14, 2023
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8HET
| Crystal structure of CTSL in complex with E64d | 分子名称: | Procathepsin L, ethyl (3S)-3-hydroxy-4-({(2S)-4-methyl-1-[(3-methylbutyl)amino]-1-oxopentan-2-yl}amino)-4-oxobutanoate | 著者 | Wang, H, Shao, M, Sun, L, Yang, H. | 登録日 | 2022-11-08 | 公開日 | 2023-12-13 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry. Nat Commun, 14, 2023
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8HD8
| Crystal structure of TMPRSS2 in complex with 212-148 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-carbamimidamidobenzoic acid, CALCIUM ION, ... | 著者 | Wang, H, Liu, X, Sun, L, Yang, H. | 登録日 | 2022-11-03 | 公開日 | 2023-12-13 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry. Nat Commun, 14, 2023
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8HE9
| Crystal structure of CTSB in complex with K777 | 分子名称: | Cathepsin B, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Wang, H, Li, D, Sun, L, Yang, H. | 登録日 | 2022-11-07 | 公開日 | 2023-12-13 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry. Nat Commun, 14, 2023
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8HFV
| Crystal structure of CTSL in complex with K777 | 分子名称: | CACODYLATE ION, Nalpha-[(4-methylpiperazin-1-yl)carbonyl]-N-[(3S)-1-phenyl-5-(phenylsulfonyl)pentan-3-yl]-L-phenylalaninamide, Procathepsin L, ... | 著者 | Wang, H, Shao, M, Sun, L, Yang, H. | 登録日 | 2022-11-12 | 公開日 | 2023-12-13 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry. Nat Commun, 14, 2023
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8HEN
| Crystal structure of CTSB in complex with 212-148 | 分子名称: | 2-[4-[[(2~{S})-1-oxidanylidene-3-phenyl-1-[[(3~{S})-1-phenyl-5-(phenylsulfonyl)pentan-3-yl]amino]propan-2-yl]carbamoyl]piperazin-1-yl]ethyl 4-carbamimidamidobenzoate, Cathepsin B, DIMETHYL SULFOXIDE, ... | 著者 | Wang, H, Li, D, Sun, L, Yang, H. | 登録日 | 2022-11-08 | 公開日 | 2023-12-13 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry. Nat Commun, 14, 2023
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8J69
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