7CQK
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![BU of 7cqk by Molmil](/molmil-images/mine/7cqk) | Cryo-EM structure of the substrate-bound SPT-ORMDL3 complex | 分子名称: | ORM1-like protein 3, Serine palmitoyltransferase 1, Serine palmitoyltransferase 2, ... | 著者 | Li, S.S, Xie, T, Wang, L, Gong, X. | 登録日 | 2020-08-11 | 公開日 | 2021-02-10 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural insights into the assembly and substrate selectivity of human SPT-ORMDL3 complex. Nat.Struct.Mol.Biol., 28, 2021
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5W0R
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![BU of 5w0r by Molmil](/molmil-images/mine/5w0r) | Crystal structure of MBP fused activation-induced cytidine deaminase (AID) in complex with cacodylic acid | 分子名称: | CACODYLATE ION, CALCIUM ION, MBP fused activation-induced cytidine deaminase, ... | 著者 | Qiao, Q, Wang, L, Wu, H. | 登録日 | 2017-05-31 | 公開日 | 2017-08-16 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | AID Recognizes Structured DNA for Class Switch Recombination. Mol. Cell, 67, 2017
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5W0U
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![BU of 5w0u by Molmil](/molmil-images/mine/5w0u) | Crystal structure of MBP fused activation-induced cytidine deaminase (AID) in complex with dCMP | 分子名称: | 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, CALCIUM ION, DNA (5'-D(*CP*TP*GP*GP*CP*CP*TP*TP*GP*AP*AP*C)-3'), ... | 著者 | Qiao, Q, Wang, L, Wu, H. | 登録日 | 2017-05-31 | 公開日 | 2017-08-16 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | AID Recognizes Structured DNA for Class Switch Recombination. Mol. Cell, 67, 2017
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5W1C
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![BU of 5w1c by Molmil](/molmil-images/mine/5w1c) | Crystal structure of MBP fused activation-induced cytidine deaminase (AID) in complex with cytidine | 分子名称: | 4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE, CALCIUM ION, DNA (5'-D(*CP*TP*GP*GP*CP*CP*TP*TP*GP*AP*AP*C)-3'), ... | 著者 | Qiao, Q, Wang, L, Wu, H. | 登録日 | 2017-06-02 | 公開日 | 2017-08-16 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.18 Å) | 主引用文献 | AID Recognizes Structured DNA for Class Switch Recombination. Mol. Cell, 67, 2017
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3R7W
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![BU of 3r7w by Molmil](/molmil-images/mine/3r7w) | Crystal Structure of Gtr1p-Gtr2p complex | 分子名称: | GTP-binding protein GTR1, GTP-binding protein GTR2, MAGNESIUM ION, ... | 著者 | Gong, R, Li, L, Liu, Y, Wang, P, Yang, H, Wang, L, Cheng, J, Guan, K.L, Xu, Y. | 登録日 | 2011-03-23 | 公開日 | 2011-08-24 | 最終更新日 | 2013-06-19 | 実験手法 | X-RAY DIFFRACTION (2.773 Å) | 主引用文献 | Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation Genes Dev., 25, 2011
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6V51
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![BU of 6v51 by Molmil](/molmil-images/mine/6v51) | Spin-labeled T4 Lysozyme (9/131FnbY)-(4-Amino-TEMPO) | 分子名称: | 4-amino-2,2,6,6-tetramethylpiperidin-1-ol, Endolysin | 著者 | Liu, J, Morizumi, T, Ou, W.L, Wang, L, Ernst, O.P. | 登録日 | 2019-12-02 | 公開日 | 2020-10-07 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Genetically Encoded Quinone Methides Enabling Rapid, Site-Specific, and Photocontrolled Protein Modification with Amine Reagents. J.Am.Chem.Soc., 142, 2020
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6NPY
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![BU of 6npy by Molmil](/molmil-images/mine/6npy) | Cryo-EM structure of NLRP3 bound to NEK7 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, NACHT, LRR and PYD domains-containing protein 3, ... | 著者 | Sharif, H, Wang, L, Wang, W.L, Wu, H. | 登録日 | 2019-01-18 | 公開日 | 2019-06-19 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome. Nature, 570, 2019
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4KFP
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![BU of 4kfp by Molmil](/molmil-images/mine/4kfp) | Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived Ureas as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) | 分子名称: | 1,2-ETHANEDIOL, N-(4-{[1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl]sulfonyl}benzyl)-2H-pyrrolo[3,4-c]pyridine-2-carboxamide, Nicotinamide phosphoribosyltransferase, ... | 著者 | Dragovich, P.S, Bair, K.W, Baumeister, T, Ho, Y, Liederer, B.M, Liu, X, O'Brien, T, Oeh, J, Sampath, D, Skelton, N, Wang, L, Wang, W, Wu, H, Xiao, Y, Yuen, P, Zak, M, Zhang, L, Zheng, X. | 登録日 | 2013-04-27 | 公開日 | 2013-08-14 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 23, 2013
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5WXB
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![BU of 5wxb by Molmil](/molmil-images/mine/5wxb) | |
3TKR
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![BU of 3tkr by Molmil](/molmil-images/mine/3tkr) | Crystal structure of full-length human peroxiredoxin 4 with T118E mutation | 分子名称: | Peroxiredoxin-4 | 著者 | Wang, X, Wang, L, Wang, X, Sun, F, Wang, C.-C. | 登録日 | 2011-08-28 | 公開日 | 2011-10-05 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4 Biochem.J., 2011
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3TKQ
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![BU of 3tkq by Molmil](/molmil-images/mine/3tkq) | Crystal structure of full-length human peroxiredoxin 4 with mixed conformation | 分子名称: | Peroxiredoxin-4 | 著者 | Wang, X, Wang, L, Wang, X, Sun, F, Wang, C.-C. | 登録日 | 2011-08-28 | 公開日 | 2011-10-05 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4 Biochem.J., 2011
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3TKS
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![BU of 3tks by Molmil](/molmil-images/mine/3tks) | Crystal structure of full-length human peroxiredoxin 4 in three different redox states | 分子名称: | PEROXIDE ION, Peroxiredoxin-4 | 著者 | Wang, X, Wang, L, Wang, X, Sun, F, Wang, C.-C. | 登録日 | 2011-08-28 | 公開日 | 2011-10-05 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4 Biochem.J., 2011
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3TKP
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![BU of 3tkp by Molmil](/molmil-images/mine/3tkp) | Crystal structure of full-length human peroxiredoxin 4 in the reduced form | 分子名称: | Peroxiredoxin-4 | 著者 | Wang, X, Wang, L, Wang, X, Sun, F, Wang, C.-C. | 登録日 | 2011-08-28 | 公開日 | 2011-10-05 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4 Biochem.J., 2011
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8X51
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![BU of 8x51 by Molmil](/molmil-images/mine/8x51) | Cryo-EM structure of Gabija GajA in complex with DNA(focused refinement) | 分子名称: | CALCIUM ION, DNA (5'-D(*AP*AP*AP*AP*AP*TP*AP*AP*CP*CP*GP*GP*GP*TP*TP*AP*TP*TP*AP*AP*A)-3'), DNA (5'-D(*TP*TP*TP*AP*AP*TP*AP*AP*CP*CP*CP*GP*GP*TP*TP*AP*TP*TP*TP*TP*T)-3'), ... | 著者 | Li, J, Wang, Z, Wang, L. | 登録日 | 2023-11-16 | 公開日 | 2024-02-28 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | Structures and activation mechanism of the Gabija anti-phage system. Nature, 629, 2024
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8WY5
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![BU of 8wy5 by Molmil](/molmil-images/mine/8wy5) | Structure of Gabija GajA in complex with DNA | 分子名称: | CALCIUM ION, DNA (5'-D(P*AP*AP*AP*AP*TP*AP*AP*CP*CP*GP*GP*GP*TP*TP*AP*TP*TP*AP*A)-3'), DNA (5'-D(P*TP*TP*AP*AP*TP*AP*AP*CP*CP*CP*GP*GP*TP*TP*AP*TP*TP*TP*T)-3'), ... | 著者 | Li, J, Wang, Z, Wang, L. | 登録日 | 2023-10-30 | 公開日 | 2024-02-28 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | Structures and activation mechanism of the Gabija anti-phage system. Nature, 629, 2024
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2ZGJ
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![BU of 2zgj by Molmil](/molmil-images/mine/2zgj) | Crystal Structure of D86N-GzmM Complexed with Its Optimal Synthesized Substrate | 分子名称: | Granzyme M, SSGKVPLS, SULFATE ION | 著者 | Wu, L.F, Wang, L, Hua, G.Q, Liu, K, Zhai, Y.J, Sun, F, Fan, Z.S. | 登録日 | 2008-01-22 | 公開日 | 2009-01-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme M J.Immunol., 183, 2009
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2ZGH
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![BU of 2zgh by Molmil](/molmil-images/mine/2zgh) | Crystal Structure of active granzyme M bound to its product | 分子名称: | Granzyme M, SSGKVPL, SULFATE ION | 著者 | Wu, L.F, Wang, L, Hua, G.Q, Liu, K, Zhai, Y.J, Sun, F, Fan, Z.S. | 登録日 | 2008-01-22 | 公開日 | 2009-01-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme M J.Immunol., 183, 2009
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5G0I
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![BU of 5g0i by Molmil](/molmil-images/mine/5g0i) | Crystal structure of Danio rerio HDAC6 CD1 and CD2 (linker cleaved) in complex with Nexturastat A | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, HDAC6, ... | 著者 | Miyake, Y, Keusch, J.J, Wang, L, Saito, M, Hess, D, Wang, X, Melancon, B.J, Helquist, P, Gut, H, Matthias, P. | 登録日 | 2016-03-18 | 公開日 | 2016-07-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Structural Insights Into Hdac6 Tubulin Deacetylation and its Selective Inhibition Nat.Chem.Biol., 12, 2016
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2ZGC
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![BU of 2zgc by Molmil](/molmil-images/mine/2zgc) | Crystal Structure of Active Human Granzyme M | 分子名称: | Granzyme M, SULFATE ION | 著者 | Wu, L.F, Wang, L, Hua, G.Q, Liu, K, Zhai, Y.J, Sun, F, Fan, Z.S. | 登録日 | 2008-01-21 | 公開日 | 2009-01-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme M J.Immunol., 183, 2009
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5G0F
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![BU of 5g0f by Molmil](/molmil-images/mine/5g0f) | Crystal structure of Danio rerio HDAC6 ZnF-UBP domain | 分子名称: | GLYCINE, HDAC6, NICKEL (II) ION, ... | 著者 | Miyake, Y, Keusch, J.J, Wang, L, Saito, M, Hess, D, Wang, X, Melancon, B.J, Helquist, P, Gut, H, Matthias, P. | 登録日 | 2016-03-18 | 公開日 | 2016-07-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural Insights Into Hdac6 Tubulin Deacetylation and its Selective Inhibition Nat.Chem.Biol., 12, 2016
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5G0H
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![BU of 5g0h by Molmil](/molmil-images/mine/5g0h) | Crystal structure of Danio rerio HDAC6 CD2 in complex with (S)- trichostatin A | 分子名称: | 1,2-ETHANEDIOL, HDAC6, POTASSIUM ION, ... | 著者 | Miyake, Y, Keusch, J.J, Wang, L, Saito, M, Hess, D, Wang, X, Melancon, B.J, Helquist, P, Gut, H, Matthias, P. | 登録日 | 2016-03-18 | 公開日 | 2016-07-27 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural Insights Into Hdac6 Tubulin Deacetylation and its Selective Inhibition Nat.Chem.Biol., 12, 2016
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5G0J
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![BU of 5g0j by Molmil](/molmil-images/mine/5g0j) | Crystal structure of Danio rerio HDAC6 CD1 and CD2 (linker intact) in complex with Nexturastat A | 分子名称: | CHLORIDE ION, HDAC6, NEXTURASTAT A, ... | 著者 | Miyake, Y, Keusch, J.J, Wang, L, Saito, M, Hess, D, Wang, X, Melancon, B.J, Helquist, P, Gut, H, Matthias, P. | 登録日 | 2016-03-18 | 公開日 | 2016-07-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | 主引用文献 | Structural Insights Into Hdac6 Tubulin Deacetylation and its Selective Inhibition Nat.Chem.Biol., 12, 2016
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3FXJ
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![BU of 3fxj by Molmil](/molmil-images/mine/3fxj) | Crystal Structure of Human Protein phosphatase 1A (PPM1A) Bound with Phosphate at 3 mM of Mn2+ | 分子名称: | MANGANESE (II) ION, PHOSPHATE ION, Protein phosphatase 1A | 著者 | Hu, T, Wang, L, Wang, K, Jiang, H, Shen, X. | 登録日 | 2009-01-21 | 公開日 | 2010-01-26 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis for the Mn2+-dependent activation of human PPM1A To be published
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3FXK
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![BU of 3fxk by Molmil](/molmil-images/mine/3fxk) | Crystal Structure of Human Protein phosphatase 1A (PPM1A) Bound with Phosphate at 10 mM of Mn2+ | 分子名称: | MANGANESE (II) ION, PHOSPHATE ION, Protein phosphatase 1A | 著者 | Hu, T, Wang, L, Wang, K, Jiang, H, Shen, X. | 登録日 | 2009-01-21 | 公開日 | 2010-01-26 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis for the Mn2+-dependent activation of human PPM1A To be published
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3FXL
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![BU of 3fxl by Molmil](/molmil-images/mine/3fxl) | Crystal Structure of Human Protein phosphatase 1A (PPM1A) Bound with Citrate at 1 mM of Mn2+ | 分子名称: | CITRATE ANION, MANGANESE (II) ION, PHOSPHATE ION, ... | 著者 | Hu, T, Wang, L, Wang, K, Jiang, H, Shen, X. | 登録日 | 2009-01-21 | 公開日 | 2010-01-26 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis for the Mn2+-dependent activation of human PPM1A To be published
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