8J9G
 
 | | CrtSPARTA hetero-dimer bound with guide-target, state 1 | | 分子名称: | DNA (25-MER), MAGNESIUM ION, Piwi domain-containing protein, ... | | 著者 | Li, Z.X, Guo, L.J, Huang, P.P, Xiao, Y.B, Chen, M.R. | | 登録日 | 2023-05-03 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system.
Nat.Chem.Biol., 20, 2024
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8J8H
 | | SPARTA monomer bound with guide-target, state 2 | | 分子名称: | DNA (25-MER), MAGNESIUM ION, Piwi domain-containing protein, ... | | 著者 | Li, Z.X, Guo, L.J, Huang, P.P, Xiao, Y.B, Chen, M.R. | | 登録日 | 2023-05-01 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system.
Nat.Chem.Biol., 20, 2024
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8J84
 | | Short ago complexed with TIR-APAZ | | 分子名称: | Piwi domain-containing protein, TIR domain-containing protein | | 著者 | Guo, L.J, Huang, P.P, Li, Z.X, Xiao, Y.B, Chen, M.R. | | 登録日 | 2023-04-30 | | 公開日 | 2024-03-13 | | 最終更新日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system.
Nat.Chem.Biol., 20, 2024
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8J9P
 | | SPARTA dimer bound with guide-target | | 分子名称: | DNA (25-MER), MAGNESIUM ION, Piwi domain-containing protein, ... | | 著者 | Li, Z.X, Guo, L.J, Huang, P.P, Xiao, Y.B, Chen, M.R. | | 登録日 | 2023-05-04 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system.
Nat.Chem.Biol., 20, 2024
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9IW3
 | | Cryo-EM structure of Lactobacillus casei DdmE bound with guide and target | | 分子名称: | DNA (25-MER), DNA (5'-D(P*CP*TP*TP*GP*AP*TP*AP*CP*GP*AP*C)-3'), DNA (5'-D(P*TP*GP*AP*CP*GP*GP*CP*TP*CP*TP*AP*AP*TP*CP*T)-3'), ... | | 著者 | Huang, P.P, Chen, M.R, Xiao, Y.B. | | 登録日 | 2024-07-25 | | 公開日 | 2025-01-01 | | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | | 主引用文献 | The mechanism of bacterial defense system DdmDE from Lactobacillus casei.
Cell Res., 34, 2024
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9IX4
 | | Cryo-EM structure of Lactobacillus casei DdmD dimer bound with DNA | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*AP*TP*GP*AP*GP*TP*AP*TP*AP*TP*CP*C)-3'), ... | | 著者 | Huang, P.P, Chen, M.R, Xiao, Y.B. | | 登録日 | 2024-07-26 | | 公開日 | 2025-01-01 | | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | | 主引用文献 | The mechanism of bacterial defense system DdmDE from Lactobacillus casei.
Cell Res., 34, 2024
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9IXM
 | | Cryo-EM structure of Lactobacillus casei DdmDE bound with DNA | | 分子名称: | DNA (30-MER), DNA (5'-D(P*TP*GP*AP*CP*GP*GP*CP*TP*CP*TP*AP*AP*TP*CP*T)-3'), DdmD, ... | | 著者 | Huang, P.P, Chen, M.R, Xiao, Y.B. | | 登録日 | 2024-07-29 | | 公開日 | 2025-01-01 | | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | | 主引用文献 | The mechanism of bacterial defense system DdmDE from Lactobacillus casei.
Cell Res., 34, 2024
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3H00
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3V5Q
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3G7A
 | | HIV gp41 six-helix bundle composed of a chimeric alpha+alpha/beta-peptide analogue of the CHR domain in complex with an NHR domain alpha-peptide | | 分子名称: | ACETYL GROUP, Chimeric alpha+alpha/beta-peptide analogue of the HIV gp41 CHR domain, Envelope glycoprotein gp160, ... | | 著者 | Horne, W.S, Johnson, L.M, Gellman, S.H. | | 登録日 | 2009-02-09 | | 公開日 | 2009-10-20 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural and biological mimicry of protein surface recognition by alpha/beta-peptide foldamers
Proc.Natl.Acad.Sci.USA, 106, 2009
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7XK8
 | | Cryo-EM structure of the Neuromedin U receptor 2 (NMUR2) in complex with G Protein and its endogeneous Peptide-Agonist NMU25 | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Zhao, W, Wenru, Z, Mu, W, Minmin, L, Shutian, C, Tingting, T, Gisela, S, Holger, W, Albert, B, Cuiying, Y, Xiaojing, C, Han, S, Wu, B, Zhao, Q. | | 登録日 | 2022-04-19 | | 公開日 | 2023-02-22 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Ligand recognition and activation of neuromedin U receptor 2.
Nat Commun, 13, 2022
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8Z3K
 | | The structure of type III CRISPR-associated deaminase in complex 2cA6-2ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Adenosine deaminase domain-containing protein, RNA (5'-R(P*AP*AP*AP*AP*AP*A)-3'), ... | | 著者 | Chen, M.R, Li, Z.X, Xiao, Y.B. | | 登録日 | 2024-04-15 | | 公開日 | 2024-12-11 | | 最終更新日 | 2025-03-05 | | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | | 主引用文献 | Antiviral signaling of a type III CRISPR-associated deaminase.
Science, 387, 2025
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8Z40
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8Z3R
 | | The structure of type III CRISPR-associated deaminase in complex cA4 | | 分子名称: | 3'-O-[(R)-{[(2S,3aS,4S,6S,6aS)-6-(6-amino-9H-purin-9-yl)-2-hydroxy-2-oxotetrahydro-2H-2lambda~5~-furo[3,4-d][1,3,2]dioxaphosphol-4-yl]methoxy}(hydroxy)phosphoryl]adenosine, Adenosine deaminase domain-containing protein, ZINC ION | | 著者 | Chen, M.R, Li, Z.X, Xiao, Y.B. | | 登録日 | 2024-04-16 | | 公開日 | 2024-12-25 | | 最終更新日 | 2025-03-05 | | 実験手法 | ELECTRON MICROSCOPY (2.28 Å) | | 主引用文献 | Antiviral signaling of a type III CRISPR-associated deaminase.
Science, 387, 2025
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8Z3P
 | | The structure of type III CRISPR-associated deaminase in complex cA6 and ATP, fully activated | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Adenosine deaminase domain-containing protein, MAGNESIUM ION, ... | | 著者 | Chen, M.R, Li, Z.X, Xiao, Y.B. | | 登録日 | 2024-04-15 | | 公開日 | 2024-12-25 | | 最終更新日 | 2025-03-05 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Antiviral signaling of a type III CRISPR-associated deaminase.
Science, 387, 2025
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7XMR
 | | CryoEM structure of the somatostatin receptor 2 (SSTR2) in complex with Gi1 and its endogeneous peptide ligand SST-14 | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Wenli, Z, Shuo, H, Na, Q, Wenbo, Z, Mengjie, L, Dehua, Y, Ming-Wei, W, Wu, B, Zhao, Q. | | 登録日 | 2022-04-26 | | 公開日 | 2022-08-03 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural insights into ligand recognition and selectivity of somatostatin receptors.
Cell Res., 32, 2022
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7XMS
 | | CryoEM structure of somatostatin receptor 4 (SSTR4) in complex with Gi1 and its endogeneous ligand SST-14 | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Wenli, Z, Shuo, H, Na, Q, Wenbo, Z, Mengjie, L, Dehua, Y, Ming-Wei, W, Wu, B, Zhao, Q. | | 登録日 | 2022-04-26 | | 公開日 | 2022-08-03 | | 最終更新日 | 2024-11-20 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural insights into ligand recognition and selectivity of somatostatin receptors.
Cell Res., 32, 2022
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7XMT
 | | CryoEM structure of somatostatin receptor 4 (SSTR4) with Gi1 and J-2156 | | 分子名称: | (2~{S})-2-[[(2~{S})-4-azanyl-2-[(4-methylnaphthalen-1-yl)sulfonylamino]butanoyl]amino]-3-phenyl-propanimidic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Wenli, Z, Shuo, H, Na, Q, Wenbo, Z, Mengjie, L, Dehua, Y, Ming-Wei, W, Wu, B, Zhao, Q. | | 登録日 | 2022-04-26 | | 公開日 | 2022-08-03 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural insights into ligand recognition and selectivity of somatostatin receptors.
Cell Res., 32, 2022
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8ZVX
 | | Crystal structure of snFPITE-n2 | | 分子名称: | GLYCEROL, PENTAETHYLENE GLYCOL, SULFATE ION, ... | | 著者 | Chen, X, Yang, H. | | 登録日 | 2024-06-12 | | 公開日 | 2025-04-02 | | 最終更新日 | 2025-05-07 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | A facultative plasminogen-independent thrombolytic enzyme from Sipunculus nudus.
Nat Commun, 16, 2025
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8ZVS
 | | Crystal structure of snFPITE-n1 | | 分子名称: | SULFATE ION, phenylmethanesulfonic acid, snFPITE-n1 | | 著者 | Chen, X, Yang, H, Hu, Y.L. | | 登録日 | 2024-06-12 | | 公開日 | 2025-04-02 | | 最終更新日 | 2025-05-07 | | 実験手法 | X-RAY DIFFRACTION (1.987 Å) | | 主引用文献 | A facultative plasminogen-independent thrombolytic enzyme from Sipunculus nudus.
Nat Commun, 16, 2025
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3H01
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3GWO
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3CK4
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4FFV
 | | Crystal Structure of Dipeptidyl Peptidase IV (DPP4, DPP-IV, CD26) in Complex with 11A19 Fab | | 分子名称: | 11A19 Fab heavy chain, 11A19 Fab light chain, Dipeptidyl peptidase 4 | | 著者 | Wang, Z, Sudom, A, Walker, N.P, Min, X. | | 登録日 | 2012-06-01 | | 公開日 | 2012-12-12 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | An Inhibitory Antibody Against DPP IV Improves Glucose Tolerance in vivo - Validation of Large Molecule Approach for DPP IV Inhibition
To be published
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4OCH
 | | Apo structure of Smr domain of MutS2 from Deinococcus radiodurans | | 分子名称: | Endonuclease MutS2, GLYCEROL | | 著者 | Zhang, H, Zhao, Y, Xu, Q, Hua, Y.J. | | 登録日 | 2014-01-09 | | 公開日 | 2014-06-25 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.4001 Å) | | 主引用文献 | Structural and functional studies of MutS2 from Deinococcus radiodurans.
Dna Repair, 21, 2014
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