3G7A

HIV gp41 six-helix bundle composed of a chimeric alpha+alpha/beta-peptide analogue of the CHR domain in complex with an NHR domain alpha-peptide

Summary for 3G7A

• Entry DOI: 10.2210/pdb3g7a/pdb
• Related: 1AIK 3F4Y 3F50
• Descriptor: Envelope glycoprotein gp160, Chimeric alpha+alpha/beta-peptide analogue of the HIV gp41 CHR domain, ACETYL GROUP, ... (5 entities in total)
• Functional Keywords: hiv, viral fusion, gp41, helix-bundle, alpha/beta-peptide, foldamer, aids, apoptosis, cell membrane, cleavage on pair of basic residues, envelope protein, fusion protein, glycoprotein, host-virus interaction, lipoprotein, membrane, palmitate, transmembrane, viral immunoevasion, virion, viral protein
• Cellular location: Transmembrane protein gp41: Virion membrane; Single-pass type I membrane protein. Surface protein gp120: Virion membrane; Peripheral membrane protein: P04580
• Total number of polymer chains: 2
• Total formula weight: 9018.22

Authors

Horne, W.S.,Johnson, L.M.,Gellman, S.H. (deposition date: 2009-02-09, release date: 2009-10-20, Last modification date: 2023-11-15)

• Primary citation: Horne, W.S.,Johnson, L.M.,Ketas, T.J.,Klasse, P.J.,Lu, M.,Moore, J.P.,Gellman, S.H.; Structural and biological mimicry of protein surface recognition by alpha/beta-peptide foldamers; Proc.Natl.Acad.Sci.USA, 106:14751-14756, 2009; PubMed: 19706443; DOI: 10.1073/pnas.0902663106

Experimental method

X-RAY DIFFRACTION (2.8 Å)