7F2K
| Crystal structure of PDE4D catalytic domain complexed with compound 17a | 分子名称: | (~{E})-4-[8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-9-oxidanyl-6-oxidanylidene-pyrano[3,2-b]xanthen-5-yl]oxybut-2-enoic acid, Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D, MAGNESIUM ION, ... | 著者 | Huang, Y.-Y, He, X, Luo, H.-B. | 登録日 | 2021-06-11 | 公開日 | 2021-10-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.10001969 Å) | 主引用文献 | Mangostanin Derivatives as Novel and Orally Active Phosphodiesterase 4 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis with Improved Safety. J.Med.Chem., 64, 2021
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7F2L
| Crystal structure of PDE4D catalytic domain complexed with compound 18a | 分子名称: | (~{E})-4-[9-[(4-fluorophenyl)methoxy]-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-6-oxidanylidene-pyrano[3,2-b]xanthen-5-yl]oxybut-2-enoic acid, Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D, MAGNESIUM ION, ... | 著者 | Huang, Y.-Y, He, X, Luo, H.-B. | 登録日 | 2021-06-11 | 公開日 | 2021-10-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.10111427 Å) | 主引用文献 | Mangostanin Derivatives as Novel and Orally Active Phosphodiesterase 4 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis with Improved Safety. J.Med.Chem., 64, 2021
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3JTD
| Calcium-free Scallop Myosin Regulatory Domain with ELC-D19A Point Mutation | 分子名称: | MAGNESIUM ION, Myosin essential light chain, striated adductor muscle, ... | 著者 | Himmel, D.M, Mui, S, O'Neall-Hennessey, E, Szent-Gyorgyi, A, Cohen, C. | 登録日 | 2009-09-11 | 公開日 | 2009-12-01 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | The on-off switch in regulated myosins: different triggers but related mechanisms. J.Mol.Biol., 394, 2009
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3JVT
| Calcium-bound Scallop Myosin Regulatory Domain (Lever Arm) with Reconstituted Complete Light Chains | 分子名称: | CALCIUM ION, MAGNESIUM ION, Myosin essential light chain, ... | 著者 | Himmel, D.M, Mui, S, O'Neall-Hennessey, E, Szent-Gyorgyi, A, Cohen, C. | 登録日 | 2009-09-17 | 公開日 | 2009-12-01 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The on-off switch in regulated myosins: different triggers but related mechanisms. J.Mol.Biol., 394, 2009
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7XMW
| Crystal structure of anti-CRISPR protein AcrVIA2 | 分子名称: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, AcrVIA2, SELENIUM ATOM, ... | 著者 | Yan, X, Li, X, Song, G. | 登録日 | 2022-04-27 | 公開日 | 2023-05-31 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Structure of AcrVIA2 and its binding mechanism to CRISPR-Cas13a. Biochem.Biophys.Res.Commun., 612, 2022
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7EN9
| Crystal structure of SARS-CoV-2 3CLpro in complex with the non-covalent inhibitor WU-02 | 分子名称: | 3C-like proteinase, 5-bromanyl-~{N}-methyl-3-nitro-2-[(4~{R},5~{S})-2-(7-oxidanylisoquinolin-4-yl)carbonyl-4-phenyl-2,7-diazaspiro[4.4]nonan-7-yl]benzamide | 著者 | Hou, N, Peng, C, Hu, Q. | 登録日 | 2021-04-16 | 公開日 | 2022-07-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Development of Highly Potent Noncovalent Inhibitors of SARS-CoV-2 3CLpro. Acs Cent.Sci., 9, 2023
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7END
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7EN8
| Crystal structure of SARS-CoV-2 3CLpro in complex with the non-covalent inhibitor WU-04 | 分子名称: | 3C-like proteinase, GLYCEROL, ~{N}-[(1~{S},2~{R})-2-[[4-bromanyl-2-(methylcarbamoyl)-6-nitro-phenyl]amino]cyclohexyl]isoquinoline-4-carboxamide | 著者 | Hou, N, Peng, C, Hu, Q. | 登録日 | 2021-04-16 | 公開日 | 2022-07-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Development of Highly Potent Noncovalent Inhibitors of SARS-CoV-2 3CLpro. Acs Cent.Sci., 9, 2023
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7ENE
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7F9Y
| ghrelin-bound ghrelin receptor in complex with Gq | 分子名称: | CHOLESTEROL, Engineered G-alpha-q subunit, Ghrelin-28, ... | 著者 | Wang, Y, Zhuang, Y, Xu, P, Xu, H.E, Jiang, Y. | 登録日 | 2021-07-05 | 公開日 | 2021-08-18 | 最終更新日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor. Nat Commun, 12, 2021
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7F9Z
| GHRP-6-bound ghrelin receptor in complex with Gq | 分子名称: | 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, Engineered G-alpha-q, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Wang, Y, Zhuang, Y, Xu, P, Xu, H.E, Jiang, Y. | 登録日 | 2021-07-05 | 公開日 | 2021-08-18 | 最終更新日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor. Nat Commun, 12, 2021
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7XZ5
| GPR119-Gs-LPC complex | 分子名称: | (4R,7R,18E)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, P, Huang, S, Jiang, Y, Xu, H.E. | 登録日 | 2022-06-02 | 公開日 | 2022-08-24 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119. Nat.Struct.Mol.Biol., 29, 2022
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7XZ6
| GPR119-Gs-APD668 complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Xu, P, Huang, S, Jiang, Y, Xu, H.E. | 登録日 | 2022-06-02 | 公開日 | 2022-08-24 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119. Nat.Struct.Mol.Biol., 29, 2022
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7WQ4
| Galanin-bound galanin receptor 2 in complex with Gq | 分子名称: | CHOLESTEROL, Engineered Guanine nucleotide-binding protein G(q) subunit alpha, Galanin, ... | 著者 | Duan, J, Shen, D.D, Xu, H.E, Zhang, Y, Jiang, Y. | 登録日 | 2022-01-24 | 公開日 | 2022-04-20 | 最終更新日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors Nat Commun, 13, 2022
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7WQ3
| Galanin-bound galanin receptor 1 in complex with Gi | 分子名称: | CHOLESTEROL, Galanin, Galanin receptor type 1, ... | 著者 | Duan, J, Shen, D.D, Xu, H.E, Zhang, Y, Jiang, Y. | 登録日 | 2022-01-24 | 公開日 | 2022-04-20 | 最終更新日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors Nat Commun, 13, 2022
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7XAB
| Crystal structure of PDE4D catalytic domain complexed with compound 22d | 分子名称: | 9-(cyclopropylmethoxy)-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-5-(pyridin-4-ylmethoxy)pyrano[3,2-b]xanthen-6-one, Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D, MAGNESIUM ION, ... | 著者 | Huang, Y.-Y, He, X, Luo, H.-B. | 登録日 | 2022-03-17 | 公開日 | 2023-02-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.00067449 Å) | 主引用文献 | Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases. Eur.J.Med.Chem., 242, 2022
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7XAA
| Crystal structure of PDE4D catalytic domain complexed with compound 21d | 分子名称: | 8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-9-oxidanyl-5-(pyridin-4-ylmethoxy)pyrano[3,2-b]xanthen-6-one, Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D, MAGNESIUM ION, ... | 著者 | Huang, Y.-Y, He, X, Luo, H.-B. | 登録日 | 2022-03-17 | 公開日 | 2023-02-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.100414 Å) | 主引用文献 | Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases. Eur.J.Med.Chem., 242, 2022
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7WJ6
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7WJ7
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7E2P
| The Crystal Structure of Mycoplasma bovis enolase | 分子名称: | Enolase | 著者 | Chen, R, Zhang, S, Gan, R, Wang, W, Ran, T, Shao, G, Xiong, Q, Feng, Z. | 登録日 | 2021-02-07 | 公開日 | 2022-02-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Evidence for the Rapid and Divergent Evolution of Mycoplasmas: Structural and Phylogenetic Analysis of Enolases. Front Mol Biosci, 8, 2022
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7E2Q
| Crystal structure of Mycoplasma pneumoniae Enolase | 分子名称: | Enolase, SULFATE ION | 著者 | Chen, R, Zhang, S, Gan, R, Wang, W, Ran, T, Xiong, Q, Shao, G, Feng, Z. | 登録日 | 2021-02-07 | 公開日 | 2022-02-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Evidence for the Rapid and Divergent Evolution of Mycoplasmas: Structural and Phylogenetic Analysis of Enolases. Front Mol Biosci, 8, 2022
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7D2G
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7D2E
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7D2H
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7DDX
| Crystal structure of KANK1 S1179F mutant in complex wtih eIF4A1 | 分子名称: | Eukaryotic initiation factor 4A-I, GLYCEROL, KN motif and ankyrin repeat domains 1, ... | 著者 | Pan, W, Xu, Y, Wei, Z. | 登録日 | 2020-10-30 | 公開日 | 2021-09-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Nephrotic-syndrome-associated mutation of KANK2 induces pathologic binding competition with physiological interactor KIF21A. J.Biol.Chem., 297, 2021
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