7DDX

Crystal structure of KANK1 S1179F mutant in complex wtih eIF4A1

Summary for 7DDX

• Entry DOI: 10.2210/pdb7ddx/pdb
• Descriptor: KN motif and ankyrin repeat domains 1, Eukaryotic initiation factor 4A-I, SULFATE ION, ... (5 entities in total)
• Functional Keywords: nephrotic syndrome, kidney ankyrin repeat-containing protein, eukaryotic initiation factor, complex, protein binding
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 2
• Total formula weight: 55147.86

Authors

Pan, W.,Xu, Y.,Wei, Z. (deposition date: 2020-10-30, release date: 2021-09-08, Last modification date: 2023-11-29)

• Primary citation: Xu, Y.,Guo, C.,Pan, W.,Zhao, C.,Ding, Y.,Xie, X.,Wei, Z.,Sun, Y.,Yu, C.; Nephrotic-syndrome-associated mutation of KANK2 induces pathologic binding competition with physiological interactor KIF21A.; J.Biol.Chem., 297:100958-100958, 2021; PubMed: 34274317; DOI: 10.1016/j.jbc.2021.100958

Experimental method

X-RAY DIFFRACTION (2.5 Å)