3FJU
| Ascaris suum carboxypeptidase inhibitor in complex with human carboxypeptidase A1 | 分子名称: | ACETATE ION, CACODYLATE ION, Carboxypeptidase A inhibitor, ... | 著者 | Sanglas, L, Aviles, F.X, Huber, R, Gomis-Ruth, F.X, Arolas, J.L. | 登録日 | 2008-12-15 | 公開日 | 2008-12-30 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Mammalian metallopeptidase inhibition at the defense barrier of Ascaris parasite Proc.Natl.Acad.Sci.USA, 106, 2009
|
|
1M4Y
| Crystal structure of HslV from Thermotoga maritima | 分子名称: | ATP-dependent protease hslV, SODIUM ION | 著者 | Song, H.K, Ramachandran, R, Bochtler, M.B, Hartmann, C, Azim, M.K, Huber, R. | 登録日 | 2002-07-05 | 公開日 | 2003-05-06 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Isolation and characterization of the prokaryotic proteasome homolog HslVU (ClpQY) from Thermotoga maritima and the crystal structure of HslV. BIOPHYS.CHEM., 100, 2003
|
|
3HGT
| |
2CGA
| |
1DX5
| Crystal structure of the thrombin-thrombomodulin complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, FORMIC ACID, ... | 著者 | Fuentes-Prior, P, Iwanaga, Y, Huber, R, Pagila, R, Rumennik, G, Seto, M, Morser, J, Light, D.R, Bode, W. | 登録日 | 1999-12-20 | 公開日 | 2000-04-10 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural Basis for the Anticoagulant Activity of the Thrombin-Thrombomodulin Complex Nature, 404, 2000
|
|
1CLW
| TAILSPIKE PROTEIN FROM PHAGE P22, V331A MUTANT | 分子名称: | TAILSPIKE PROTEIN | 著者 | Steinbacher, S, Baxa, U, Weintraub, A, Huber, R, Seckler, R. | 登録日 | 1999-05-04 | 公開日 | 1999-11-05 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Mutations improving the folding of phage P22 tailspike protein affect its receptor binding activity. J.Mol.Biol., 293, 1999
|
|
3HGQ
| |
2QZX
| Secreted aspartic proteinase (Sap) 5 from Candida albicans | 分子名称: | Candidapepsin-5, Pepstatin | 著者 | Lee, J.H, Ruge, E, Borelli, C, Maskos, K, Huber, R. | 登録日 | 2007-08-17 | 公開日 | 2008-07-08 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | X-ray structures of Sap1 and Sap5: Structural comparison of the secreted aspartic proteinases from Candida albicans. Proteins, 72, 2008
|
|
1XHA
| Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants | 分子名称: | N-{4-[(4-{3-[(2R)-3,3-DIMETHYLPIPERIDIN-2-YL]-2-FLUORO-6-HYDROXYBENZOYL}BENZOYL)AMINO]AZEPAN-3-YL}ISONICOTINAMIDE, cAMP-dependent protein kinase inhibitor, alpha form, ... | 著者 | Breitenlechner, C.B, Friebe, W.-G, Brunet, E, Werner, G, Graul, K, Thomas, U, Kuenkele, K.-P, Schaefer, W, Gassel, M, Bossemeyer, D, Huber, R, Engh, R.A, Masjost, B. | 登録日 | 2004-09-17 | 公開日 | 2005-09-17 | 最終更新日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants J.Med.Chem., 48, 2005
|
|
1XH6
| Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants | 分子名称: | N-(4-{[4-(2-HYDROXY-5-PIPERIDIN-1-YLBENZOYL)BENZOYL]AMINO}AZEPAN-3-YL)ISONICOTINAMIDE, cAMP-dependent protein kinase inhibitor, alpha form, ... | 著者 | Breitenlechner, C.B, Friebe, W.-G, Brunet, E, Werner, G, Graul, K, Thomas, U, Kuenkele, K.-P, Schaefer, W, Gassel, M, Bossemeyer, D, Huber, R, Engh, R.A, Masjost, B. | 登録日 | 2004-09-17 | 公開日 | 2005-09-17 | 最終更新日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants J.Med.Chem., 48, 2005
|
|
1XH8
| Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants | 分子名称: | N-[4-({4-[5-(4,4-DIMETHYLPIPERIDIN-1-YL)-2-HYDROXYBENZOYL]BENZOYL}AMINO)AZEPAN-3-YL]ISONICOTINAMIDE, cAMP-dependent protein kinase inhibitor, alpha form, ... | 著者 | Breitenlechner, C.B, Friebe, W.-G, Brunet, E, Werner, G, Graul, K, Thomas, U, Kuenkele, K.-P, Schaefer, W, Gassel, M, Bossemeyer, D, Huber, R, Engh, R.A, Masjost, B. | 登録日 | 2004-09-17 | 公開日 | 2005-09-17 | 最終更新日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants J.Med.Chem., 48, 2005
|
|
1OB0
| Kinetic stabilization of Bacillus licheniformis alpha-amylase through introduction of hydrophobic residues at the surface | 分子名称: | ALPHA-AMYLASE, CALCIUM ION, SODIUM ION | 著者 | Machius, M, Declerck, N, Huber, R, Wiegand, G. | 登録日 | 2003-01-21 | 公開日 | 2003-01-30 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Kinetic Stabilization of Bacillus Licheniformis Alpha-Amylase Through Introduction of Hydrophobic Residues at the Surface J.Biol.Chem., 278, 2003
|
|
1XH5
| Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants | 分子名称: | (R,R)-2,3-BUTANEDIOL, N-{4-[(4-{3-[(2R)-3,3-DIMETHYLPIPERIDIN-2-YL]-2-FLUORO-6-HYDROXYBENZOYL}BENZOYL)AMINO]AZEPAN-3-YL}ISONICOTINAMIDE, cAMP-dependent protein kinase inhibitor, ... | 著者 | Breitenlechner, C.B, Friebe, W.-G, Brunet, E, Werner, G, Graul, K, Thomas, U, Kuenkele, K.-P, Schaefer, W, Gassel, M, Bossemeyer, D, Huber, R, Engh, R.A, Masjost, B. | 登録日 | 2004-09-17 | 公開日 | 2005-09-17 | 最終更新日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants J.Med.Chem., 48, 2005
|
|
1XH9
| Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants | 分子名称: | (R,R)-2,3-BUTANEDIOL, N-[4-({4-[5-(DIMETHYLAMINO)-2-HYDROXYBENZOYL]BENZOYL}AMINO)AZEPAN-3-YL]ISONICOTINAMIDE, cAMP-dependent protein kinase inhibitor, ... | 著者 | Breitenlechner, C.B, Friebe, W.-G, Brunet, E, Werner, G, Graul, K, Thomas, U, Kuenkele, K.-P, Schaefer, W, Gassel, M, Bossemeyer, D, Huber, R, Engh, R.A, Masjost, B. | 登録日 | 2004-09-17 | 公開日 | 2005-09-17 | 最終更新日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants J.Med.Chem., 48, 2005
|
|
1XH4
| Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants | 分子名称: | N-[4-({4-[5-(DIMETHYLAMINO)-2-HYDROXYBENZOYL]BENZOYL}AMINO)AZEPAN-3-YL]ISONICOTINAMIDE, cAMP-dependent protein kinase inhibitor, alpha form, ... | 著者 | Breitenlechner, C.B, Friebe, W.-G, Brunet, E, Werner, G, Graul, K, Thomas, U, Kuenkele, K.-P, Schaefer, W, Gassel, M, Bossemeyer, D, Huber, R, Engh, R.A, Masjost, B. | 登録日 | 2004-09-17 | 公開日 | 2005-09-17 | 最終更新日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants J.Med.Chem., 48, 2005
|
|
1XH7
| Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants | 分子名称: | N-[4-({4-[5-(3,3-DIMETHYLPIPERIDIN-1-YL)-2-HYDROXYBENZOYL]BENZOYL}AMINO)AZEPAN-3-YL]ISONICOTINAMIDE, cAMP-dependent protein kinase inhibitor, alpha form, ... | 著者 | Breitenlechner, C.B, Friebe, W.-G, Brunet, E, Werner, G, Graul, K, Thomas, U, Kuenkele, K.-P, Schaefer, W, Gassel, M, Bossemeyer, D, Huber, R, Engh, R.A, Masjost, B. | 登録日 | 2004-09-17 | 公開日 | 2005-09-17 | 最終更新日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants J.Med.Chem., 48, 2005
|
|
5LP9
| FimA wt from S. flexneri | 分子名称: | Major type 1 subunit fimbrin (Pilin) | 著者 | Zyla, D, Capitani, G, Prota, A, Glockshuber, R. | 登録日 | 2016-08-12 | 公開日 | 2017-12-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (0.88626635 Å) | 主引用文献 | Alternative folding to a monomer or homopolymer is a common feature of the type 1 pilus subunit FimA from enteroinvasive bacteria. J.Biol.Chem., 2019
|
|
2A58
| Structure of 6,7-Dimethyl-8-ribityllumazine synthase from Schizosaccharomyces pombe mutant W27Y with bound riboflavin | 分子名称: | 6,7-dimethyl-8-ribityllumazine synthase, PHOSPHATE ION, RIBOFLAVIN | 著者 | Koch, M, Breithaupt, C, Gerhardt, S, Haase, I, Weber, S, Cushman, M, Huber, R, Bacher, A, Fischer, M. | 登録日 | 2005-06-30 | 公開日 | 2005-07-19 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis of charge transfer complex formation by riboflavin bound to 6,7-dimethyl-8-ribityllumazine synthase Eur.J.Biochem., 271, 2004
|
|
2A57
| Structure of 6,7-Dimthyl-8-ribityllumazine synthase from Schizosaccharomyces pombe mutant W27Y with bound ligand 6-carboxyethyl-7-oxo-8-ribityllumazine | 分子名称: | 3-[8-((2S,3S,4R)-2,3,4,5-TETRAHYDROXYPENTYL)-2,4,7-TRIOXO-1,3,8-TRIHYDROPTERIDIN-6-YL]PROPANOIC ACID, 6,7-dimethyl-8-ribityllumazine synthase, PHOSPHATE ION | 著者 | Koch, M, Breithaupt, C, Gerhardt, S, Haase, I, Weber, S, Cushman, M, Huber, R, Bacher, A, Fischer, M. | 登録日 | 2005-06-30 | 公開日 | 2005-07-19 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structural basis of charge transfer complex formation by riboflavin bound to 6,7-dimethyl-8-ribityllumazine synthase Eur.J.Biochem., 271, 2004
|
|
2A59
| Structure of 6,7-Dimethyl-8-ribityllumazine synthase from Schizosaccharomyces pombe mutant W27Y with bound ligand 5-nitroso-6-ribitylamino-2,4(1H,3H)-pyrimidinedione | 分子名称: | 5-NITROSO-6-RIBITYL-AMINO-2,4(1H,3H)-PYRIMIDINEDIONE, 6,7-dimethyl-8-ribityllumazine synthase, PHOSPHATE ION | 著者 | Koch, M, Breithaupt, C, Gerhardt, S, Haase, I, Weber, S, Cushman, M, Huber, R, Bacher, A, Fischer, M. | 登録日 | 2005-06-30 | 公開日 | 2005-07-19 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis of charge transfer complex formation by riboflavin bound to 6,7-dimethyl-8-ribityllumazine synthase Eur.J.Biochem., 271, 2004
|
|
1MVN
| PPC decarboxylase mutant C175S complexed with pantothenoylaminoethenethiol | 分子名称: | 2,4-DIHYDROXY-N-[2-(2-MERCAPTO-VINYLCARBAMOYL)-ETHYL]-3,3-DIMETHYL-BUTYRAMIDE, FLAVIN MONONUCLEOTIDE, PPC decarboxylase AtHAL3a | 著者 | Steinbacher, S, Hernandez-Acosta, P, Bieseler, B, Blaesse, M, Huber, R, Culianez-Macia, F.A, Kupke, T. | 登録日 | 2002-09-26 | 公開日 | 2003-03-04 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Crystal Structure of the Plant PPC Decarboxylase AtHAL3a Complexed with an Ene-thiol Reaction Intermediate J.Mol.Biol., 327, 2003
|
|
1N6E
| tricorn protease in complex with a tridecapeptide chloromethyl ketone derivative | 分子名称: | DQTQKAAAELTFF, Tricorn protease | 著者 | Kim, J.-S, Groll, M, Huber, R, Brandstetter, H. | 登録日 | 2002-11-10 | 公開日 | 2002-12-30 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Navigation Inside a Protease: Substrate Selection and Product Exit in the Tricorn Protease
from Thermoplasma acidophilum J.Mol.Biol., 324, 2002
|
|
1N6F
| tricorn protease in complex with Z-Phe-diketo-Arg-Glu-Phe | 分子名称: | 4-[2-(3-BENZYLOXYCARBONYLAMINO-4-CYCLOHEXYL-1-HYDROXY-2-OXO-BUTYLAMINO)-5-GUANIDINO-PENTANOYLAMINO]-4-(1-CARBOXY-2-CYCLOHEXYL-ETHYLCARBAMOYL)-BUTYRIC ACID, tricorn protease | 著者 | Kim, J.-S, Groll, M, Huber, R, Brandstetter, H. | 登録日 | 2002-11-10 | 公開日 | 2002-12-30 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Navigation Inside a Protease: Substrate Selection and Product Exit in the Tricorn Protease
from Thermoplasma acidophilum J.Mol.Biol., 324, 2002
|
|
1VPE
| CRYSTALLOGRAPHIC ANALYSIS OF PHOSPHOGLYCERATE KINASE FROM THE HYPERTHERMOPHILIC BACTERIUM THERMOTOGA MARITIMA | 分子名称: | 3-PHOSPHOGLYCERIC ACID, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Auerbach, G, Huber, R, Graettinger, M, Zaiss, K, Schurig, H, Jaenicke, R, Jacob, U. | 登録日 | 1997-05-06 | 公開日 | 1998-06-17 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Closed structure of phosphoglycerate kinase from Thermotoga maritima reveals the catalytic mechanism and determinants of thermal stability. Structure, 5, 1997
|
|
3CSP
| Crystal structure of the DM2 mutant of myelin oligodendrocyte glycoprotein | 分子名称: | Myelin-oligodendrocyte glycoprotein | 著者 | Breithaupt, C, Schafer, B, Pellkofer, H, Huber, R, Linington, C, Jacob, U. | 登録日 | 2008-04-10 | 公開日 | 2008-10-21 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Demyelinating myelin oligodendrocyte glycoprotein-specific autoantibody response is focused on one dominant conformational epitope region in rodents J.Immunol., 181, 2008
|
|