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NVGSNTY segment from Islet Amyloid Polypeptide (IAPP or Amylin), dehydrated crystal form
分子名称:	NVGSNTY heptapeptide segment from Islet Amyloid Polypeptide
著者	Wiltzius, J.J.W, Sawaya, M.R, Eisenberg, D.
登録日	2009-01-13
公開日	2009-06-30
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Molecular mechanisms for protein-encoded inheritance Nat.Struct.Mol.Biol., 16, 2009

3FTU

Leukotriene A4 hydrolase in complex with dihydroresveratrol
分子名称:	5-[2-(4-hydroxyphenyl)ethyl]benzene-1,3-diol, ACETATE ION, IMIDAZOLE, ...
著者	Davies, D.R.
登録日	2009-01-13
公開日	2009-07-28
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

3FU6

Leukotriene A4 hydrolase in complex with fragment (4-thiophen-2-ylphenyl)methanamine
分子名称:	1-(4-thiophen-2-ylphenyl)methanamine, ACETATE ION, IMIDAZOLE, ...
著者	Davies, D.R.
登録日	2009-01-14
公開日	2009-07-28
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.05 Å)
主引用文献	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

3FUN

Leukotriene A4 hydrolase in complex with {4-[(2R)-pyrrolidin-2-ylmethoxy]phenyl}(4-thiophen-3-ylphenyl)methanone
分子名称:	ACETATE ION, IMIDAZOLE, Leukotriene A-4 hydrolase, ...
著者	Davies, D.R.
登録日	2009-01-14
公開日	2009-07-28
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.58 Å)
主引用文献	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

3FTH

NFLVHSS segment from Islet Amyloid Polypeptide (IAPP or Amylin)
分子名称:	NFLVHSS heptapeptide from Islet Amyloid Polypeptide, SULFATE ION
著者	Wiltzius, J.J.W, Sawaya, M.R, Eisenberg, D.
登録日	2009-01-13
公開日	2009-06-30
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (1.84 Å)
主引用文献	Molecular mechanisms for protein-encoded inheritance Nat.Struct.Mol.Biol., 16, 2009

3FTS

Leukotriene A4 hydrolase in complex with resveratrol
分子名称:	ACETATE ION, IMIDAZOLE, Leukotriene A-4 hydrolase, ...
著者	Davies, D.R.
登録日	2009-01-13
公開日	2009-07-28
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.33 Å)
主引用文献	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

3FU5

Leukotriene A4 hydrolase in complex with (5-thiophen-2-ylthiophen-2-yl)methylamine
分子名称:	1-(2,2'-bithiophen-5-yl)methanamine, ACETATE ION, IMIDAZOLE, ...
著者	Davies, D.R.
登録日	2009-01-14
公開日	2009-07-28
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

3FUJ

Leukotriene A4 hydrolase in complex with 5-[2-(1H-pyrrol-1-yl)ethoxy]-1H-indole
分子名称:	5-[2-(1H-pyrrol-1-yl)ethoxy]-1H-indole, ACETATE ION, IMIDAZOLE, ...
著者	Davies, D.R.
登録日	2009-01-14
公開日	2009-07-28
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

3FVA

NNQNTF segment from elk prion
分子名称:	Major prion protein
著者	Apostol, M.I, Eisenberg, D.
登録日	2009-01-15
公開日	2009-06-30
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (1.458 Å)
主引用文献	Molecular mechanisms for protein-encoded inheritance. Nat.Struct.Mol.Biol., 16, 2009

3FTK

NVGSNTY segment from Islet Amyloid Polypeptide (IAPP or Amylin), hydrated crystal form
分子名称:	NVGSNTY heptapeptide segment from Islet Amyloid Polypeptide
著者	Wiltzius, J.J.W, Sawaya, M.R, Eisenberg, D.
登録日	2009-01-13
公開日	2009-06-30
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (1.5 Å)
主引用文献	Molecular mechanisms for protein-encoded inheritance Nat.Struct.Mol.Biol., 16, 2009

3FTV

Leukotriene A4 hydrolase in complex with fragment N-(pyridin-3-ylmethyl)aniline
分子名称:	IMIDAZOLE, Leukotriene A-4 hydrolase, N-(pyridin-3-ylmethyl)aniline, ...
著者	Davies, D.R.
登録日	2009-01-13
公開日	2009-07-28
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

3G45

Crystal structure of human phosphodiesterase 4b with regulatory domain and d155988
分子名称:	8-(3-nitrophenyl)-6-(pyridin-4-ylmethyl)quinoline, MAGNESIUM ION, ZINC ION, ...
著者	Staker, B.L.
登録日	2009-02-03
公開日	2010-01-19
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (2.63 Å)
主引用文献	Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. Nat.Biotechnol., 28, 2010

3FUM

Leukotriene A4 hydrolase in complex with (R)-pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanol
分子名称:	(R)-pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanol, ACETATE ION, IMIDAZOLE, ...
著者	Davies, D.R.
登録日	2009-01-14
公開日	2009-07-28
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.15 Å)
主引用文献	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

3G4G

Crystal structure of human phosphodiesterase 4d with regulatory domain and d155871
分子名称:	1-(3-nitrophenyl)-3-(pyridin-4-ylmethyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione, CALCIUM ION, MAGNESIUM ION, ...
著者	Staker, B.L.
登録日	2009-02-03
公開日	2010-01-19
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. Nat.Biotechnol., 28, 2010

3FUE

Leukotriene A4 hydrolase in complex with fragment 5-chloroindole and bestatin
分子名称:	2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, 5-chloro-1H-indole, IMIDAZOLE, ...
著者	Davies, D.R.
登録日	2009-01-14
公開日	2009-07-28
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.38 Å)
主引用文献	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

3FTW

Leukotriene A4 hydrolase in complex with fragments N-(pyridin-3-ylmethyl)aniline and acetate
分子名称:	ACETATE ION, IMIDAZOLE, Leukotriene A-4 hydrolase, ...
著者	Davies, D.R.
登録日	2009-01-13
公開日	2009-07-28
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.85 Å)
主引用文献	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

3FUD

Leukotriene A4 hydrolase in complex with N-methyl-1-(2-thiophen-2-ylphenyl)methanamine
分子名称:	ACETATE ION, IMIDAZOLE, Leukotriene A-4 hydrolase, ...
著者	Davies, D.R.
登録日	2009-01-14
公開日	2009-07-28
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009

3G4L

Crystal structure of human phosphodiesterase 4d with roflumilast
分子名称:	1,2-ETHANEDIOL, 3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-(DIFLUOROMETHOXY)BENZAMIDE, MAGNESIUM ION, ...
著者	Staker, B.L.
登録日	2009-02-03
公開日	2010-01-19
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. Nat.Biotechnol., 28, 2010

3G58

Crystal structure of human phosphodiesterase 4d with d155988/pmnpq
分子名称:	1,2-ETHANEDIOL, 8-(3-nitrophenyl)-6-(pyridin-4-ylmethyl)quinoline, MAGNESIUM ION, ...
著者	Staker, B.L.
登録日	2009-02-04
公開日	2010-01-19
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (2.05 Å)
主引用文献	Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. Nat.Biotechnol., 28, 2010

3DS6

P38 complex with a phthalazine inhibitor
分子名称:	Mitogen-activated protein kinase 14, N-cyclopropyl-4-methyl-3-[1-(2-methylphenyl)phthalazin-6-yl]benzamide
著者	Herberich, B, Syed, R, Li, V, Grosfeld, D.
登録日	2008-07-11
公開日	2008-10-07
最終更新日	2024-04-03
実験手法	X-RAY DIFFRACTION (2.9 Å)
主引用文献	Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold. J.Med.Chem., 51, 2008

3G4K

Crystal structure of human phosphodiesterase 4d with rolipram
分子名称:	1,2-ETHANEDIOL, MAGNESIUM ION, ROLIPRAM, ...
著者	Staker, B.L.
登録日	2009-02-03
公開日	2010-01-19
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (1.95 Å)
主引用文献	Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. Nat.Biotechnol., 28, 2010

3EUI

A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6042 in a large unit cell
分子名称:	3,6-Bis{3-[(2R)-(2-ethylpiperidino)]propionamido}acridine, 3-[(2R)-2-ethylpiperidin-1-yl]-N-[6-({3-[(2S)-2-ethylpiperidin-1-yl]propanoyl}amino)acridin-3-yl]propanamide, 5'-D(DGPDGPDGPDGPDTPDTPDTPDTPDGPDGPDGPDG)-3', ...
著者	Campbell, N.H, Parkinson, G, Neidle, S.
登録日	2008-10-10
公開日	2008-12-02
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Selectivity in Ligand Recognition of G-Quadruplex Loops. Biochemistry, 48, 2009

3ERU

A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6045
分子名称:	3,6-Bis{3-[(2R)-2-methylpiperidino)]propionamido}acridine, 5'-D(DGPDGPDGPDGPDTPDTPDTPDTPDGPDGPDGPDG)-3', POTASSIUM ION
著者	Campbell, N.H, Parkinson, G, Neidle, S.
登録日	2008-10-03
公開日	2008-10-14
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Selectivity in Ligand Recognition of G-Quadruplex Loops. Biochemistry, 48, 2009

3EUM

A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6066
分子名称:	3,6-Bis[3-(azepan-1-yl)propionamido]acridine, 5'-D(DGPDGPDGPDGPDTPDTPDTPDTPDGPDGPDGPDG)-3', POTASSIUM ION
著者	Campbell, N.H, Parkinson, G, Neidle, S.
登録日	2008-10-10
公開日	2008-10-21
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.78 Å)
主引用文献	Selectivity in Ligand Recognition of G-Quadruplex Loops. Biochemistry, 48, 2009

3ES0

A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6048
分子名称:	3,6-Bis[3-(4-methylpiperidino)propionamido]acridine, 5'-D(DGPDGPDGPDGPDTPDTPDTPDTPDGPDGPDGPDG)-3', POTASSIUM ION
著者	Campbell, N.H, Parkinson, G, Neidle, S.
登録日	2008-10-03
公開日	2008-10-14
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Selectivity in Ligand Recognition of G-Quadruplex Loops. Biochemistry, 48, 2009

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