8A6P
 
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8A6Q
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8A7V
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5DD6
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5DD3
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6XFV
 | | CRYSTAL STRUCTURE OF RAR-RELATED ORPHAN RECEPTOR C IN COMPLEX WITH A NOVEL INVERSE AGONIST | | 分子名称: | 1-(4-{(3S,4S)-4-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-methyl-3-phenylpyrrolidine-1-carbonyl}piperidin-1-yl)ethan-1-one, Nuclear receptor ROR-gamma | | 著者 | Sack, J.S. | | 登録日 | 2020-06-16 | | 公開日 | 2020-08-12 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Discovery of (3S,4S)-3-methyl-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxyprop-2-yl)phenyl)pyrrolidines as novel ROR gamma t inverse agonists.
Bioorg.Med.Chem.Lett., 30, 2020
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4QVD
 | | E.coli Hfq in complex with RNA Ads | | 分子名称: | RNA (5'-R(*AP*AP*CP*UP*AP*AP*A)-3'), RNA-binding protein Hfq | | 著者 | Wang, L.J, Wang, W.W, Li, F.D, Wu, J.H, Gong, Q.G, Shi, Y.Y. | | 登録日 | 2014-07-14 | | 公開日 | 2015-05-27 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.972 Å) | | 主引用文献 | Structural insights into the recognition of the internal A-rich linker from OxyS sRNA by Escherichia coli Hfq
Nucleic Acids Res., 43, 2015
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6LAT
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5VAN
 | | Crystal Structure of Beta-Klotho | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Lee, S, Schlessinger, J. | | 登録日 | 2017-03-27 | | 公開日 | 2018-01-31 | | 最終更新日 | 2021-03-24 | | 実験手法 | X-RAY DIFFRACTION (2.202 Å) | | 主引用文献 | Structures of beta-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.
Nature, 553, 2018
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8ZF1
 | | Crystal structure of a Chemo Triplet Photoenzyme (CTPe) | | 分子名称: | N-(9-oxidanylidenethioxanthen-2-yl)ethanamide, Transcriptional regulator, PadR-like family | | 著者 | Chen, X, Qian, J.Y, Guo, J, Wu, Y.Z, Zhong, F.R. | | 登録日 | 2024-05-07 | | 公開日 | 2024-07-17 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Chemogenetic Evolution of Diversified Photoenzymes for Enantioselective [2 + 2] Cycloadditions in Whole Cells.
J.Am.Chem.Soc., 146, 2024
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5DD5
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5OLM
 | | TRIM21 | | 分子名称: | E3 ubiquitin-protein ligase TRIM21, ZINC ION | | 著者 | James, L.C. | | 登録日 | 2017-07-28 | | 公開日 | 2018-04-25 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21.
Elife, 7, 2018
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4DCH
 | | Insights into Glucokinase Activation Mechanism: Observation of Multiple Distinct Protein Conformations | | 分子名称: | (2R)-3-cyclopentyl-2-[4-(methylsulfonyl)phenyl]-N-(1,3-thiazol-2-yl)propanamide, Glucokinase, IODIDE ION, ... | | 著者 | Greasley, S.E, Hickey, M, Feng, J, Garcia, E. | | 登録日 | 2012-01-17 | | 公開日 | 2012-02-08 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Insights into Mechanism of Glucokinase Activation: OBSERVATION OF MULTIPLE DISTINCT PROTEIN CONFORMATIONS.
J.Biol.Chem., 287, 2012
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8AM4
 | | Cl-rsEGFP2 Long Wavelength Structure | | 分子名称: | Green fluorescent protein | | 著者 | Orr, C.M, Fadini, A, van Thor, J. | | 登録日 | 2022-08-02 | | 公開日 | 2023-08-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Serial Femtosecond Crystallography Reveals that Photoactivation in a Fluorescent Protein Proceeds via the Hula Twist Mechanism.
J.Am.Chem.Soc., 2023
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5W0T
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8FBZ
 | | Crystal Structure of apo human Glutathione Synthetase Y270E | | 分子名称: | GLYCEROL, Glutathione synthetase, SULFATE ION | | 著者 | Stanford, S.M, Santelli, E, Sankaran, B, Murali, R, Bottini, N. | | 登録日 | 2022-11-30 | | 公開日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | Targeting prostate tumor low-molecular weight tyrosine phosphatase for oxidation-sensitizing therapy.
Sci Adv, 10, 2024
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6LB0
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4IOU
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7RR9
 | | Cryo-EM Structure of Nanodisc reconstituted ABCD1 in nucleotide bound outward open conformation | | 分子名称: | ATP-binding cassette sub-family D member 1, CHOLESTEROL, MAGNESIUM ION, ... | | 著者 | Alam, A, Le, L.T.M, Thompson, J.R. | | 登録日 | 2021-08-09 | | 公開日 | 2022-01-19 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structures of the human peroxisomal fatty acid transporter ABCD1 in a lipid environment
Commun Biol, 5, 2022
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7RRA
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6L8T
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4RSE
 | | Crystal structure of RPE65 in complex with MB-001 and palmitate | | 分子名称: | (1R)-3-amino-1-{3-[(2,6,6-trimethylcyclohex-1-en-1-yl)methoxy]phenyl}propan-1-ol, FE (II) ION, PALMITIC ACID, ... | | 著者 | Kiser, P.D, Shi, W, Palczewski, K. | | 登録日 | 2014-11-07 | | 公開日 | 2015-04-15 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | Catalytic mechanism of a retinoid isomerase essential for vertebrate vision.
Nat.Chem.Biol., 11, 2015
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5VAK
 | | Crystal Structure of Beta-Klotho, Domain 1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-klotho, ... | | 著者 | Lee, S, Schlessinger, J. | | 登録日 | 2017-03-27 | | 公開日 | 2018-01-31 | | 最終更新日 | 2021-03-24 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structures of beta-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.
Nature, 553, 2018
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4U00
 | | Crystal structure of TTHA1159 in complex with ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Amino acid ABC transporter, ATP-binding protein, ... | | 著者 | Karthiga Devi, S, Chichili, V.P.R, Velmurugan, D, Sivaraman, J. | | 登録日 | 2014-07-11 | | 公開日 | 2015-05-13 | | 最終更新日 | 2024-06-26 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural basis for the hydrolysis of ATP by a nucleotide binding subunit of an amino acid ABC transporter from Thermus thermophilus
J.Struct.Biol., 190, 2015
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8YBR
 | | Choline transporter BetT | | 分子名称: | BCCT family transporter | | 著者 | Yang, T.J, Nian, Y.W, Lin, H.J, Li, J, Zhang, J.R, Fan, M.R. | | 登録日 | 2024-02-16 | | 公開日 | 2024-09-04 | | 実験手法 | ELECTRON MICROSCOPY (2.57 Å) | | 主引用文献 | Structure and mechanism of the osmoregulated choline transporter BetT.
Sci Adv, 10, 2024
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