6SZV
 
 | | Bat Influenza A polymerase elongation complex with incoming UTP analogue (core + endonuclease only) | | 分子名称: | 3' vRNA, 5' vRNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, ... | | 著者 | Wandzik, J.M, Kouba, T, Cusack, S. | | 登録日 | 2019-10-02 | | 公開日 | 2020-04-15 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
|
|
6T0U
 | | Bat Influenza A polymerase product dissociation complex using 44-mer vRNA template with intact oligo(U) sequence | | 分子名称: | Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit, ... | | 著者 | Wandzik, J.M, Kouba, T, Cusack, S. | | 登録日 | 2019-10-03 | | 公開日 | 2020-04-15 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | | 主引用文献 | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
|
|
8AZA
 | | Structure of RIP2K dimer bound to the XIAP BIR2 domain | | 分子名称: | E3 ubiquitin-protein ligase XIAP, Receptor-interacting serine/threonine-protein kinase 2, ZINC ION | | 著者 | Pellegrini, E, Cusack, S. | | 登録日 | 2022-09-05 | | 公開日 | 2022-10-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | | 主引用文献 | Structure shows that the BIR2 domain of E3 ligase XIAP binds across the RIPK2 kinase dimer interface.
Life Sci Alliance, 6, 2023
|
|
6SZU
 | | Bat Influenza A polymerase pre-termination complex with pyrophosphate using 44-mer vRNA template with mutated oligo(U) sequence | | 分子名称: | 5-oxidanyl-4-oxidanylidene-1-[(1-pyrrolo[2,3-b]pyridin-1-ylcyclopentyl)methyl]pyridine-3-carboxylic acid, MAGNESIUM ION, PYROPHOSPHATE 2-, ... | | 著者 | Wandzik, J.M, Kouba, T, Cusack, S. | | 登録日 | 2019-10-02 | | 公開日 | 2020-04-15 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (2.41 Å) | | 主引用文献 | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
|
|
6T0V
 | | Bat Influenza A polymerase elongation complex with incoming UTP analogue (complete polymerase) | | 分子名称: | 3' vRNA, 5' vRNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, ... | | 著者 | Wandzik, J.M, Kouba, T, Cusack, S. | | 登録日 | 2019-10-03 | | 公開日 | 2020-04-15 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | | 主引用文献 | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
|
|
6T0W
 | | Human Influenza B polymerase recycling complex | | 分子名称: | Polymerase PB2, Polymerase acidic protein, RNA-directed RNA polymerase catalytic subunit, ... | | 著者 | Wandzik, J.M, Kouba, T, Karuppasamy, M, Cusack, S. | | 登録日 | 2019-10-03 | | 公開日 | 2020-04-15 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | | 主引用文献 | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
|
|
7PQK
 | |
8ASG
 | | Structure of the SFTSV L protein bound in a resting state [RESTING] | | 分子名称: | MAGNESIUM ION, RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*CP*AP*GP*AP*UP*GP*A*)-3'), RNA (5'-R(*GP*AP*UP*CP*UP*GP*GP*GP*CP*GP*GP*UP*CP*UP*UP*UP*GP*UP*GP*U*)-3'), ... | | 著者 | Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | | 登録日 | 2022-08-19 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.
Nucleic Acids Res., 51, 2023
|
|
8ASB
 | | Structure of the SFTSV L protein stalled at early elongation with the endonuclease domain in a raised conformation [EARLY-ELONGATION-ENDO] | | 分子名称: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, MAGNESIUM ION, RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*CP*AP*GP*A)-3'), ... | | 著者 | Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | | 登録日 | 2022-08-18 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.
Nucleic Acids Res., 51, 2023
|
|
8ASD
 | | Structure of the SFTSV L protein stalled at late elongation [LATE-ELONGATION] | | 分子名称: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, MAGNESIUM ION, RNA (5'-R(P*AP*AP*AP*AP*AP*AP*GP*AP*UP*CP*UP*GP*GP*GP*CP*GP*GP*UP*CP*UP*UP*UP*GP*UP*GP*U)-3'), ... | | 著者 | Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | | 登録日 | 2022-08-19 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.
Nucleic Acids Res., 51, 2023
|
|
8AS6
 | | Structure of the SFTSV L protein bound to 5' cRNA hook [5' HOOK] | | 分子名称: | RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*C)-3'), RNA-dependent RNA-polymerase L protein | | 著者 | Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | | 登録日 | 2022-08-18 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.
Nucleic Acids Res., 51, 2023
|
|
8AS7
 | | Structure of the SFTSV L protein stalled at early elongation [EARLY-ELONGATION] | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, MAGNESIUM ION, ... | | 著者 | Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | | 登録日 | 2022-08-18 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.
Nucleic Acids Res., 51, 2023
|
|
6T2C
 | | Bat Influenza A polymerase recycling complex | | 分子名称: | MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ... | | 著者 | Wandzik, J.M, Kouba, T, Cusack, S. | | 登録日 | 2019-10-08 | | 公開日 | 2020-04-15 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | | 主引用文献 | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
|
|
6TW1
 | | Bat Influenza A polymerase termination complex with pyrophosphate using 44-mer vRNA template with mutated oligo(U) sequence | | 分子名称: | 5-oxidanyl-4-oxidanylidene-1-[(1-pyrrolo[2,3-b]pyridin-1-ylcyclopentyl)methyl]pyridine-3-carboxylic acid, MAGNESIUM ION, PYROPHOSPHATE 2-, ... | | 著者 | Wandzik, J.M, Kouba, T, Cusack, S. | | 登録日 | 2020-01-11 | | 公開日 | 2020-04-15 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 2020
|
|
1QHV
 | | HUMAN ADENOVIRUS SEROTYPE 2 FIBRE HEAD | | 分子名称: | PROTEIN (ADENOVIRUS FIBRE), SULFATE ION | | 著者 | Van Raaij, M.J, Louis, N, Chroboczek, J, Cusack, S. | | 登録日 | 1999-05-28 | | 公開日 | 1999-09-29 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | | 主引用文献 | Structure of the human adenovirus serotype 2 fiber head domain at 1.5 A resolution.
Virology, 262, 1999
|
|
1QIU
 | |
8BY6
 | | Structure of the human nuclear cap-binding complex bound to NCBP3(560-620) and cap-analogue m7GpppG | | 分子名称: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2, ... | | 著者 | Dubiez, E, Pellegrini, E, Foucher, A.E, Cusack, S, Kadlec, J. | | 登録日 | 2022-12-12 | | 公開日 | 2024-01-24 | | 最終更新日 | 2024-01-31 | | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | | 主引用文献 | Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex.
Cell Rep, 43, 2024
|
|
5NG2
 | |
8CI5
 | | Structure of the SNV L protein bound to 5' RNA | | 分子名称: | RNA (5'-R(P*AP*GP*UP*AP*GP*UP*AP*GP*AP*CP*U)-3'), RNA-directed RNA polymerase L | | 著者 | Meier, K, Thorkelsson, S.R, Durieux Trouilleton, Q, Vogel, D, Yu, D, Kosinski, J, Cusack, S, Malet, H, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | | 登録日 | 2023-02-08 | | 公開日 | 2023-07-19 | | 最終更新日 | 2023-08-23 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural and functional characterization of the Sin Nombre virus L protein.
Plos Pathog., 19, 2023
|
|
5NG0
 | | Structure of RIP2K(L294F) with bound AMPPCP | | 分子名称: | COBALT (II) ION, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | | 著者 | Pellegrini, E, Cusack, S. | | 登録日 | 2017-03-16 | | 公開日 | 2017-06-07 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation.
PLoS ONE, 12, 2017
|
|
5NG3
 | | Structure of inactive kinase RIP2K(K47R) | | 分子名称: | Receptor-interacting serine/threonine-protein kinase 2, SULFATE ION | | 著者 | Pellegrini, E, Cusack, S. | | 登録日 | 2017-03-16 | | 公開日 | 2017-06-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation.
PLoS ONE, 12, 2017
|
|
1D4R
 | | 29-mer fragment of human srp rna helix 6 | | 分子名称: | 29-MER OF MODIFIED SRP RNA HELIX 6, MAGNESIUM ION | | 著者 | Wild, K, Weichenrieder, O, Leonard, G.A, Cusack, S. | | 登録日 | 1999-10-05 | | 公開日 | 1999-12-02 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The 2 A structure of helix 6 of the human signal recognition particle RNA
Structure Fold.Des., 7, 1999
|
|
1E8O
 | | Core of the Alu domain of the mammalian SRP | | 分子名称: | 7SL RNA, SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN, SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN, ... | | 著者 | Weichenrieder, O, Wild, K, Strub, K, Cusack, S. | | 登録日 | 2000-09-28 | | 公開日 | 2000-11-08 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structure and Assembly of the Alu Domain of the Mammalian Signal Recognition Particle
Nature, 408, 2000
|
|
1E8S
 | | Alu domain of the mammalian SRP (potential Alu retroposition intermediate) | | 分子名称: | 7SL RNA, 88-MER, EUROPIUM (III) ION, ... | | 著者 | Weichenrieder, O, Wild, K, Strub, K, Cusack, S. | | 登録日 | 2000-09-29 | | 公開日 | 2000-11-08 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (4 Å) | | 主引用文献 | Structure and Assembly of the Alu Domain of the Mammalian Signal Recognition Particle
Nature, 408, 2000
|
|
1ZZI
 | | Crystal Structure Analysis of the third KH domain of hnRNP K in complex with ssDNA | | 分子名称: | 5'-D(*CP*TP*CP*CP*CP*C)-3', Heterogeneous nuclear ribonucleoprotein K | | 著者 | Backe, P.H, Messias, A.C, Ravelli, R.B, Sattler, M, Cusack, S. | | 登録日 | 2005-06-14 | | 公開日 | 2005-08-09 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | X-Ray Crystallographic and NMR Studies of the Third KH Domain of hnRNP K in Complex with Single-Stranded Nucleic Acids
STRUCTURE, 13, 2005
|
|
