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Focussed refinement of InvGN0N1:PrgHK:SpaPQR:PrgIJ from Salmonella SPI-1 injectisome NC-base
分子名称:	Lipoprotein PrgK, Protein InvG, Protein PrgH, ...
著者	Hu, J, Worrall, L.J, Strynadka, N.C.J.
登録日	2019-08-02
公開日	2019-10-23
最終更新日	2020-01-15
実験手法	ELECTRON MICROSCOPY (4.1 Å)
主引用文献	T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly. Nat Microbiol, 4, 2019

6QD9

Leishmania major N-myristoyltransferase in complex with thienopyrimidine inhibitor IMP-0000065
分子名称:	3-[[2-[3-(dimethylamino)propyl-methyl-amino]thieno[3,2-d]pyrimidin-4-yl]-methyl-amino]propanenitrile, Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, ...
著者	Brannigan, J.A.
登録日	2019-01-01
公開日	2020-05-06
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (1.46 Å)
主引用文献	Novel Thienopyrimidine Inhibitors of Leishmania N -Myristoyltransferase with On-Target Activity in Intracellular Amastigotes. J.Med.Chem., 63, 2020

6QDH

Leishmania major N-myristoyltransferase in complex with quinazoline inhibitor IMP-0000906
分子名称:	4-[ethyl(methyl)amino]-2-[methyl-(1-methylpiperidin-4-yl)amino]-~{N}-(1,3,5-trimethylpyrazol-4-yl)quinazoline-6-sulfonamide, Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, ...
著者	Brannigan, J.A.
登録日	2019-01-01
公開日	2020-05-06
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (1.45 Å)
主引用文献	Novel Thienopyrimidine Inhibitors of Leishmania N -Myristoyltransferase with On-Target Activity in Intracellular Amastigotes. J.Med.Chem., 63, 2020

6QDE

Leishmania major N-myristoyltransferase in complex with thienopyrimidine inhibitor IMP-0000877
分子名称:	3-[[6-~{tert}-butyl-2-[3-(dimethylamino)propyl-methyl-amino]thieno[3,2-d]pyrimidin-4-yl]-methyl-amino]propanenitrile, Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, ...
著者	Brannigan, J.A.
登録日	2019-01-01
公開日	2020-05-06
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (1.45 Å)
主引用文献	Novel Thienopyrimidine Inhibitors of Leishmania N -Myristoyltransferase with On-Target Activity in Intracellular Amastigotes. J.Med.Chem., 63, 2020

6QDF

Leishmania major N-myristoyltransferase in complex with thienopyrimidine inhibitor IMP-0000096
分子名称:	3-[[6-tert-butyl-2-[methyl-[(3S)-1-methylpyrrolidin-3-yl]amino]thieno[3,2-d]pyrimidin-4-yl]-methyl-amino]propanenitrile, Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, ...
著者	Brannigan, J.A.
登録日	2019-01-01
公開日	2020-05-06
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (1.49 Å)
主引用文献	Novel Thienopyrimidine Inhibitors of Leishmania N -Myristoyltransferase with On-Target Activity in Intracellular Amastigotes. J.Med.Chem., 63, 2020

6QDC

Leishmania major N-myristoyltransferase in complex with thienopyrimidine inhibitor IMP-0000101
分子名称:	3-[[2-[(1-ethylpiperidin-4-yl)-methyl-amino]thieno[3,2-d]pyrimidin-4-yl]-methyl-amino]propanenitrile, Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, ...
著者	Brannigan, J.A.
登録日	2019-01-01
公開日	2020-05-06
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (1.4 Å)
主引用文献	Novel Thienopyrimidine Inhibitors of Leishmania N -Myristoyltransferase with On-Target Activity in Intracellular Amastigotes. J.Med.Chem., 63, 2020

6QDD

Leishmania major N-myristoyltransferase in complex with thienopyrimidine inhibitor IMP-0000105
分子名称:	2-[(2~{S})-1-[2-[methyl-(1-methylpiperidin-4-yl)amino]thieno[3,2-d]pyrimidin-4-yl]-2,3-dihydropyrrol-2-yl]ethanenitrile, DIMETHYL SULFOXIDE, Glycylpeptide N-tetradecanoyltransferase, ...
著者	Brannigan, J.A.
登録日	2019-01-01
公開日	2020-05-06
最終更新日	2024-05-15
実験手法	X-RAY DIFFRACTION (1.65 Å)
主引用文献	Novel Thienopyrimidine Inhibitors of Leishmania N -Myristoyltransferase with On-Target Activity in Intracellular Amastigotes. J.Med.Chem., 63, 2020

8SBE

Structure of the rat vesicular glutamate transporter 2 determined by single-particle Cryo-EM
分子名称:	Vesicular glutamate transporter 2
著者	Li, F, Finer-Moore, J, Eriksen, J, Cheng, Y, Edwards, R, Stroud, R.
登録日	2023-04-03
公開日	2023-05-03
実験手法	ELECTRON MICROSCOPY (3.8 Å)
主引用文献	Ion transport and regulation in a synaptic vesicle glutamate transporter. Science, 368, 2020

3N2Y

Crystal structure of tyrosyl-tRNA synthetase complexed with p-(2-tetrazolyl)-phenylalanine
分子名称:	4-(2H-tetrazol-2-yl)-L-phenylalanine, Tyrosyl-tRNA synthetase
著者	Wu, M, Li, J, Zang, J.
登録日	2010-05-19
公開日	2010-11-03
最終更新日	2023-11-01
実験手法	X-RAY DIFFRACTION (2.49 Å)
主引用文献	A biosynthetic route to photoclick chemistry on proteins J.Am.Chem.Soc., 132, 2010

7JN4

Rubisco in the apo state
分子名称:	Ribulose bisphosphate carboxylase large chain, Ribulose bisphosphate carboxylase small chain 2, chloroplastic
著者	Matthies, D, Jonikas, M.C, He, S.
登録日	2020-08-03
公開日	2020-11-18
最終更新日	2020-12-23
実験手法	ELECTRON MICROSCOPY (2.68 Å)
主引用文献	The structural basis of Rubisco phase separation in the pyrenoid. Nat.Plants, 6, 2020

7JSX

EPYC1(106-135) peptide-bound Rubisco
分子名称:	EPYC1, Ribulose bisphosphate carboxylase large chain, Ribulose bisphosphate carboxylase small chain 2, ...
著者	Matthies, D, He, S, Jonikas, M.C.
登録日	2020-08-16
公開日	2020-11-18
最終更新日	2020-12-23
実験手法	ELECTRON MICROSCOPY (2.06 Å)
主引用文献	The structural basis of Rubisco phase separation in the pyrenoid. Nat.Plants, 6, 2020

7JFO

EPYC1(49-72)-bound Rubisco
分子名称:	LCI5, Ribulose bisphosphate carboxylase large chain, Ribulose bisphosphate carboxylase small chain 2, ...
著者	Matthies, D, Jonikas, M.C, He, S.
登録日	2020-07-17
公開日	2020-11-18
最終更新日	2020-12-23
実験手法	ELECTRON MICROSCOPY (2.13 Å)
主引用文献	The structural basis of Rubisco phase separation in the pyrenoid. Nat.Plants, 6, 2020

7LFS

Crystal structure of the epidermal growth factor receptor extracellular region with A265V mutation in complex with epiregulin
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 4 of Epidermal growth factor receptor, ...
著者	Hu, C, Leche II, C.A, Stayrook, S.E, Ferguson, K.M, Lemmon, M.A.
登録日	2021-01-18
公開日	2021-11-17
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (3.5 Å)
主引用文献	Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias. Nature, 602, 2022

7LEN

Crystal structure of the epidermal growth factor receptor extracellular region with R84K mutation in complex with epiregulin crystallized with trehalose
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者	Hu, C, Leche II, C.A, Stayrook, S.E, Ferguson, K.M, Lemmon, M.A.
登録日	2021-01-14
公開日	2021-11-17
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.9 Å)
主引用文献	Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias. Nature, 602, 2022

7LFR

Crystal structure of the epidermal growth factor receptor extracellular region with R84K mutation in complex with epiregulin crystallized with spermine
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, Proepiregulin, ...
著者	Hu, C, Leche II, C.A, Stayrook, S.E, Ferguson, K.M, Lemmon, M.A.
登録日	2021-01-18
公開日	2021-11-17
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (3.2 Å)
主引用文献	Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias. Nature, 602, 2022

8H1T

Cryo-EM structure of BAP1-ASXL1 bound to chromatosome
分子名称:	DNA (187-MER), Histone H1.4, Histone H2A type 1-D, ...
著者	Ge, W, Yu, C, Xu, R.M.
登録日	2022-10-04
公開日	2023-02-01
最終更新日	2023-04-19
実験手法	ELECTRON MICROSCOPY (3 Å)
主引用文献	Basis of the H2AK119 specificity of the Polycomb repressive deubiquitinase. Nature, 616, 2023

7N9F

Structure of the in situ yeast NPC
分子名称:	Dynein light chain 1, cytoplasmic, Nucleoporin 145c, ...
著者	Villa, E, Singh, D, Ludtke, S.J, Akey, C.W, Rout, M.P, Echeverria, I, Suslov, S.
登録日	2021-06-17
公開日	2022-01-26
最終更新日	2024-06-05
実験手法	ELECTRON MICROSCOPY (37 Å)
主引用文献	Comprehensive structure and functional adaptations of the yeast nuclear pore complex. Cell, 185, 2022

7N84

Double nuclear outer ring from the isolated yeast NPC
分子名称:	Nucleoporin 145c, Nucleoporin NUP120, Nucleoporin NUP133, ...
著者	Akey, C.W, Rout, M.P, Ouch, C, Echevarria, I, Fernandez-Martinez, J, Nudelman, I.
登録日	2021-06-13
公開日	2022-01-26
最終更新日	2024-06-05
実験手法	ELECTRON MICROSCOPY (11.6 Å)
主引用文献	Comprehensive structure and functional adaptations of the yeast nuclear pore complex. Cell, 185, 2022

7N85

Inner ring spoke from the isolated yeast NPC
分子名称:	Nucleoporin ASM4, Nucleoporin NIC96, Nucleoporin NSP1, ...
著者	Akey, C.W, Rout, M.P, Ouch, C, Echevarria, I, Fernandez-Martinez, J, Nudelman, I.
登録日	2021-06-13
公開日	2022-01-26
最終更新日	2024-06-05
実験手法	ELECTRON MICROSCOPY (7.6 Å)
主引用文献	Comprehensive structure and functional adaptations of the yeast nuclear pore complex. Cell, 185, 2022

7Y5U

Cryo-EM structure of the monomeric human CAF1LC-H3-H4 complex
分子名称:	Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, Histone H3.1, ...
著者	Liu, C.P, Yu, Z.Y, Yu, C, Xu, R.M.
登録日	2022-06-17
公開日	2023-08-16
最終更新日	2023-09-06
実験手法	ELECTRON MICROSCOPY (3.8 Å)
主引用文献	Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science, 381, 2023

7Y5W

Cryo-EM structure of the left-handed Di-tetrasome
分子名称:	Histone H3.1, Histone H4, Widom 601 DNA (147-MER)
著者	Liu, C.P, Yu, Z.Y, Yu, C, Xu, R.M.
登録日	2022-06-17
公開日	2023-08-16
最終更新日	2023-09-06
実験手法	ELECTRON MICROSCOPY (3.5 Å)
主引用文献	Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science, 381, 2023

7Y60

Cryo-EM structure of human CAF1LC bound right-handed Di-tetrasome
分子名称:	Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, Histone H3.1, ...
著者	Liu, C.P, Yu, C, Yu, Z.Y, Xu, R.M.
登録日	2022-06-18
公開日	2023-08-16
最終更新日	2023-09-06
実験手法	ELECTRON MICROSCOPY (3.8 Å)
主引用文献	Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science, 381, 2023

7Y61

Cryo-EM structure of the two CAF1LCs bound right-handed Di-tetrasome
分子名称:	Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, Histone H3.1, ...
著者	Liu, C.P, Yu, Z.Y, Yu, C, Xu, R.M.
登録日	2022-06-18
公開日	2023-08-16
最終更新日	2023-09-06
実験手法	ELECTRON MICROSCOPY (5.6 Å)
主引用文献	Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science, 381, 2023

7Y5V

Cryo-EM structure of the dimeric human CAF1LC-H3-H4 complex
分子名称:	Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, Histone H3.1, ...
著者	Liu, C.P, Yu, C, Yu, Z.Y, Xu, R.M.
登録日	2022-06-17
公開日	2023-08-16
最終更新日	2023-09-06
実験手法	ELECTRON MICROSCOPY (6.1 Å)
主引用文献	Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science, 381, 2023

3RIK

The acid beta-glucosidase active site exhibits plasticity in binding 3,4,5,6-tetrahydroxyazepane-based inhibitors: implications for pharmacological chaperone design for gaucher disease
分子名称:	(3S,4R,5R,6S)-1-(2-hydroxyethyl)azepane-3,4,5,6-tetrol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glucosylceramidase, ...
著者	Orwig, S.D, Lieberman, R.L.
登録日	2011-04-13
公開日	2012-03-14
最終更新日	2020-07-29
実験手法	X-RAY DIFFRACTION (2.48 Å)
主引用文献	Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-beta-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease Biochemistry, 50, 2011

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