6QDE

Leishmania major N-myristoyltransferase in complex with thienopyrimidine inhibitor IMP-0000877

Summary for 6QDE

Entry DOI	10.2210/pdb6qde/pdb
Related	4CGO
Descriptor	Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, 3-[[6-~{tert}-butyl-2-[3-(dimethylamino)propyl-methyl-amino]thieno[3,2-d]pyrimidin-4-yl]-methyl-amino]propanenitrile, ... (5 entities in total)
Functional Keywords	transferase, myristoylation, benzothiophene, leishmania
Biological source	Leishmania major
Total number of polymer chains	1
Total formula weight	50350.58
Authors	Brannigan, J.A. (deposition date: 2019-01-01, release date: 2020-05-06, Last modification date: 2024-01-24)
Primary citation	Bell, A.S.,Yu, Z.,Hutton, J.A.,Wright, M.H.,Brannigan, J.A.,Paape, D.,Roberts, S.M.,Sutherell, C.L.,Ritzefeld, M.,Wilkinson, A.J.,Smith, D.F.,Leatherbarrow, R.J.,Tate, E.W. Novel Thienopyrimidine Inhibitors of Leishmania N -Myristoyltransferase with On-Target Activity in Intracellular Amastigotes. J.Med.Chem., 63:7740-7765, 2020 Cited by PubMed: 32575985 DOI: 10.1021/acs.jmedchem.0c00570 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation