4HY1
 
 | Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. | 分子名称: | 6-({4-[(3R)-3-aminopyrrolidin-1-yl]-5-chloro-6-ethyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)-1H-isoindol-1-one, Topoisomerase IV, subunit B | 著者 | Bensen, D.C, Creighton, C.J, Kwan, B, Tari, L.W. | 登録日 | 2012-11-12 | 公開日 | 2013-02-13 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. Bioorg.Med.Chem.Lett., 23, 2013
|
|
8ZB0
 
 | Cryo-EM structure of human ZnT1 | 分子名称: | Proton-coupled zinc antiporter SLC30A1, ZINC ION | 著者 | Sun, S, Xie, E, Xu, S, Ji, S. | 登録日 | 2024-04-25 | 公開日 | 2025-03-12 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | The Intestinal Transporter SLC30A1 Plays a Critical Role in Regulating Systemic Zinc Homeostasis. Adv Sci, 11, 2024
|
|
7E8M
 
 | Crystal structure of SARS-CoV-2 antibody P2C-1F11 with mutated RBD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, antibody P2C-1F11 heavy chain, ... | 著者 | Wang, X.Q, Zhang, L.Q, Ge, J.W, Wang, R.K, Lan, J. | 登録日 | 2021-03-02 | 公開日 | 2021-05-26 | 最終更新日 | 2024-11-20 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species. Immunity, 54, 2021
|
|
8ZCE
 
 | Cryo-EM structure of GPR4 complexed with Gs in pH6.0 | 分子名称: | G-protein coupled receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yue, X.L, Wu, L.J, Hua, T, Liu, Z.J. | 登録日 | 2024-04-29 | 公開日 | 2025-04-23 | 最終更新日 | 2025-06-18 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis of stepwise proton sensing-mediated GPCR activation. Cell Res., 35, 2025
|
|
8ZCF
 
 | Cryo-EM structure of GPR4 complexed with Gs in pH7.5 | 分子名称: | G-protein coupled receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yue, X.L, Wu, L.J, Hua, T, Liu, Z.J. | 登録日 | 2024-04-29 | 公開日 | 2025-04-23 | 最終更新日 | 2025-06-25 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis of stepwise proton sensing-mediated GPCR activation. Cell Res., 35, 2025
|
|
7VON
 
 | Native alpha-2-macroglobulin monomer | 分子名称: | Alpha-2-macroglobulin | 著者 | Huang, X, Wang, Y. | 登録日 | 2021-10-14 | 公開日 | 2022-11-16 | 最終更新日 | 2024-10-23 | 実験手法 | ELECTRON MICROSCOPY (5.2 Å) | 主引用文献 | Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor. Sci China Life Sci, 65, 2022
|
|
8XK2
 
 | A neutralizing nanobody VHH60 against wt SARS-CoV-2 | 分子名称: | Spike protein S1, VHH60 nanobody | 著者 | Lu, Y, Guo, H, Ji, X, Yang, H. | 登録日 | 2023-12-22 | 公開日 | 2024-07-10 | 最終更新日 | 2024-11-06 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | A broad neutralizing nanobody against SARS-CoV-2 engineered from an approved drug. Cell Death Dis, 15, 2024
|
|
8XKI
 
 | A neutralizing nanobody VHH60 against wt SARS-CoV-2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Lu, Y, Guo, H, Ji, X, Yang, H. | 登録日 | 2023-12-23 | 公開日 | 2024-07-10 | 最終更新日 | 2025-07-02 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | A broad neutralizing nanobody against SARS-CoV-2 engineered from an approved drug. Cell Death Dis, 15, 2024
|
|
7VOO
 
 | Induced alpha-2-macroglobulin monomer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... | 著者 | Huang, X, Wang, Y, Ping, Z. | 登録日 | 2021-10-14 | 公開日 | 2022-10-19 | 最終更新日 | 2024-11-06 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor. Sci China Life Sci, 65, 2022
|
|
7X7R
 
 | Cryo-EM structure of a bacterial protein | 分子名称: | RAMP superfamily protein, RNA (36-MER), RNA (5'-R(P*AP*GP*UP*CP*CP*GP*GP*GP*GP*CP*AP*GP*AP*AP*AP*AP*UP*UP*GP*G)-3'), ... | 著者 | Yu, G, Wang, X, Deng, Z, Zhang, H. | 登録日 | 2022-03-10 | 公開日 | 2022-11-16 | 最終更新日 | 2025-06-25 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure and function of a bacterial type III-E CRISPR-Cas7-11 complex. Nat Microbiol, 7, 2022
|
|
7XC7
 
 | Cryo-EM structure of a bacterial protein complex | 分子名称: | CHAT domain protein, RAMP superfamily protein, RNA (33-MER), ... | 著者 | Yu, G, Wang, X, Deng, Z, Zhang, H. | 登録日 | 2022-03-23 | 公開日 | 2022-11-16 | 最終更新日 | 2025-06-25 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure and function of a bacterial type III-E CRISPR-Cas7-11 complex. Nat Microbiol, 7, 2022
|
|
7X8A
 
 | Cryo-EM structure of a bacterial protein complex | 分子名称: | CHAT domain protein, RAMP superfamily protein, RNA (33-MER), ... | 著者 | Yu, G, Wang, X, Deng, Z, Zhang, H. | 登録日 | 2022-03-11 | 公開日 | 2022-11-16 | 最終更新日 | 2025-06-25 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structure and function of a bacterial type III-E CRISPR-Cas7-11 complex. Nat Microbiol, 7, 2022
|
|
7X7A
 
 | Cryo-EM structure of SbCas7-11 in complex with crRNA and target RNA | 分子名称: | RAMP superfamily protein, RNA (33-MER), ZINC ION | 著者 | Yu, G, Wang, X, Deng, Z, Zhang, H. | 登録日 | 2022-03-09 | 公開日 | 2022-11-16 | 最終更新日 | 2025-06-25 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure and function of a bacterial type III-E CRISPR-Cas7-11 complex. Nat Microbiol, 7, 2022
|
|
6BAN
 
 | |
8WWM
 
 | MCH-MCHR1-Gi complex, L2 state | 分子名称: | Antibody fragment ScFv16, Fusion protein 1,Melanin-concentrating hormone receptor 1,Fusion protein 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Gong, W, Ye, X, Liu, G. | 登録日 | 2023-10-25 | 公開日 | 2024-11-13 | 最終更新日 | 2024-12-18 | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | 主引用文献 | Structural insights into physiological activation and antagonism of melanin-concentrating hormone receptor MCHR1. Cell Discov, 10, 2024
|
|
8WWK
 
 | MCH-MCHR1-Gi complex, T1 state | 分子名称: | Antibody fragment ScFv16, Fusion protein 1,Melanin-concentrating hormone receptor 1,Fusion protein 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Gong, W, Ye, X, Liu, G. | 登録日 | 2023-10-25 | 公開日 | 2024-11-13 | 最終更新日 | 2024-12-18 | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | 主引用文献 | Structural insights into physiological activation and antagonism of melanin-concentrating hormone receptor MCHR1. Cell Discov, 10, 2024
|
|
8WWN
 
 | MCH-MCHR1-Gi complex,L1 state | 分子名称: | Antibody fragment ScFv16, Fusion protein 1,Melanin-concentrating hormone receptor 1,Fusion protein 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Gong, W, Ye, X, Liu, G. | 登録日 | 2023-10-25 | 公開日 | 2024-11-13 | 最終更新日 | 2024-12-18 | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | 主引用文献 | Structural insights into physiological activation and antagonism of melanin-concentrating hormone receptor MCHR1. Cell Discov, 10, 2024
|
|
8J1Z
 
 | |
8WWL
 
 | MCH-MCHR1-Gi complex, T2 state | 分子名称: | Antibody fragment ScFv16, Fusion protein 1,Melanin-concentrating hormone receptor 1,Fusion protein 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Gong, W, Ye, X, Liu, G. | 登録日 | 2023-10-25 | 公開日 | 2024-11-13 | 最終更新日 | 2024-12-18 | 実験手法 | ELECTRON MICROSCOPY (2.78 Å) | 主引用文献 | Structural insights into physiological activation and antagonism of melanin-concentrating hormone receptor MCHR1. Cell Discov, 10, 2024
|
|
7VBO
 
 | Alginate binding domain CBM | 分子名称: | Alginate lyase, CALCIUM ION, SULFATE ION | 著者 | Ji, S.Q, She, Q. | 登録日 | 2021-09-01 | 公開日 | 2022-09-07 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Identification and structural analysis of a carbohydrate-binding module specific to alginate, a representative of a new family, CBM96. J.Biol.Chem., 299, 2023
|
|
7W6S
 
 | CryoEM structure of human KChIP2-Kv4.3 complex | 分子名称: | Isoform 2 of Potassium voltage-gated channel subfamily D member 3, Kv channel-interacting protein 2 | 著者 | Ma, D.M, Guo, J.T. | 登録日 | 2021-12-02 | 公開日 | 2022-11-02 | 最終更新日 | 2025-06-25 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis for the gating modulation of Kv4.3 by auxiliary subunits. Cell Res., 32, 2022
|
|
7W6N
 
 | CryoEM structure of human KChIP1-Kv4.3 complex | 分子名称: | Isoform 2 of Potassium voltage-gated channel subfamily D member 3, Kv channel-interacting protein 1 | 著者 | Ma, D.M, Guo, J.T. | 登録日 | 2021-12-02 | 公開日 | 2022-11-02 | 最終更新日 | 2025-07-02 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis for the gating modulation of Kv4.3 by auxiliary subunits. Cell Res., 32, 2022
|
|
7W6T
 
 | CryoEM structure of human KChIP1-Kv4.3-DPP6 complex | 分子名称: | Dipeptidyl aminopeptidase-like protein 6, Isoform 2 of Potassium voltage-gated channel subfamily D member 3, Kv channel-interacting protein 1 | 著者 | Ma, D.M, Guo, J.T. | 登録日 | 2021-12-02 | 公開日 | 2022-11-02 | 最終更新日 | 2025-07-02 | 実験手法 | ELECTRON MICROSCOPY (3.85 Å) | 主引用文献 | Structural basis for the gating modulation of Kv4.3 by auxiliary subunits. Cell Res., 32, 2022
|
|
7W0D
 
 | Dicer2-LoqsPD-dsRNA complex at mid-translocation state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Dicer-2, isoform A, ... | 著者 | Su, S, Wang, J, Wang, H.W, Ma, J. | 登録日 | 2021-11-18 | 公開日 | 2022-04-27 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (4.18 Å) | 主引用文献 | Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607, 2022
|
|
7W0A
 
 | dmDicer2-LoqsPD-dsRNA Dimer status | 分子名称: | Dicer-2, isoform A, Loquacious, ... | 著者 | Su, S, Wang, J, Wang, H.W, Ma, J. | 登録日 | 2021-11-18 | 公開日 | 2022-04-27 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607, 2022
|
|