8WWN

MCH-MCHR1-Gi complex,L1 state

Summary for 8WWN

• Entry DOI: 10.2210/pdb8wwn/pdb
• EMDB information: 37894
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: mch complex gpcr mchr1 agonist, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 187094.10

Authors

Gong, W.,Ye, X.,Liu, G. (deposition date: 2023-10-25, release date: 2024-11-13, Last modification date: 2024-12-18)

• Primary citation: Ye, X.,Liu, G.,Li, X.,He, B.,Tao, Y.,Guan, J.,Mu, Y.,Liu, H.,Gong, W.; Structural insights into physiological activation and antagonism of melanin-concentrating hormone receptor MCHR1.; Cell Discov, 10:124-124, 2024; PubMed: 39616153; DOI: 10.1038/s41421-024-00754-0

Experimental method

ELECTRON MICROSCOPY (2.65 Å)