3BE2
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![BU of 3be2 by Molmil](/molmil-images/mine/3be2) | Crystal structure of the VEGFR2 kinase domain in complex with a benzamide inhibitor | 分子名称: | N-{3-[3-(DIMETHYLAMINO)PROPYL]-5-(TRIFLUOROMETHYL)PHENYL}-4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]BENZAMIDE, Vascular endothelial growth factor receptor 2 | 著者 | Whittington, D.A, Kim, J.L, Long, A.M, Gu, Y, Rose, P, Zhao, H. | 登録日 | 2007-11-16 | 公開日 | 2008-04-08 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: design, synthesis, and evaluation. J.Med.Chem., 51, 2008
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2A4Q
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![BU of 2a4q by Molmil](/molmil-images/mine/2a4q) | HCV NS3 protease with NS4a peptide and a covalently bound macrocyclic ketoamide compound. | 分子名称: | (2R)-({N-[(3S)-3-({[(3S,6S)-6-CYCLOHEXYL-5,8-DIOXO-4,7-DIAZABICYCLO[14.3.1]ICOSA-1(20),16,18-TRIEN-3-YL]CARBONYL}AMINO)-2-OXOHEXANOYL]GLYCYL}AMINO)(PHENYL)ACETIC ACID, BETA-MERCAPTOETHANOL, NS3 protease/helicase', ... | 著者 | Chen, K.X, Njoroge, F.G, Prongay, A, Pichardo, J, Madison, V, Girijavallabhan, V. | 登録日 | 2005-06-29 | 公開日 | 2006-07-04 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Synthesis and Biological Activity of Macrocyclic Inhibitors of Hepatitis C Virus (HCV) NS3 Protease Bioorg.Med.Chem.Lett., 15, 2005
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3B8R
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![BU of 3b8r by Molmil](/molmil-images/mine/3b8r) | Crystal structure of the VEGFR2 kinase domain in complex with a naphthamide inhibitor | 分子名称: | 1,2-ETHANEDIOL, N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide, Vascular endothelial growth factor receptor 2 | 著者 | Whittington, D.A, Long, A.M, Gu, Y, Zhao, H. | 登録日 | 2007-11-01 | 公開日 | 2008-04-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Evaluation of a Series of Naphthamides as Potent, Orally Active Vascular
Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitors J.Med.Chem., 51, 2008
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6XQA
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![BU of 6xqa by Molmil](/molmil-images/mine/6xqa) | Crystal Structure of HLA A*2402 in complex with TYQWVLKNL, an 9-mer epitope from Influenza B virus | 分子名称: | Beta-2-microglobulin, MAGNESIUM ION, MHC class I antigen, ... | 著者 | Nguyen, A.T, Szeto, C, Gras, S. | 登録日 | 2020-07-09 | 公開日 | 2021-04-14 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | 主引用文献 | CD8 + T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph. Nat Commun, 12, 2021
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1XUC
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![BU of 1xuc by Molmil](/molmil-images/mine/1xuc) | Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor | 分子名称: | CALCIUM ION, Collagenase 3, N,N'-BIS(3-METHYLBENZYL)PYRIMIDINE-4,6-DICARBOXAMIDE, ... | 著者 | Engel, C.K, Wendt, K.U. | 登録日 | 2004-10-26 | 公開日 | 2005-10-26 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural basis for the highly selective inhibition of MMP-13 Chem.Biol., 12, 2005
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1XUD
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![BU of 1xud by Molmil](/molmil-images/mine/1xud) | Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor | 分子名称: | CALCIUM ION, Collagenase 3, N,N'-BIS(4-FLUORO-3-METHYLBENZYL)PYRIMIDINE-4,6-DICARBOXAMIDE, ... | 著者 | Engel, C.K, Wendt, K.U. | 登録日 | 2004-10-26 | 公開日 | 2005-10-26 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural basis for the highly selective inhibition of MMP-13. Chem.Biol., 12, 2005
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2HHL
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![BU of 2hhl by Molmil](/molmil-images/mine/2hhl) | Crystal structure of the human small CTD phosphatase 3 isoform 1 | 分子名称: | 12-TUNGSTOPHOSPHATE, CTD small phosphatase-like protein | 著者 | Malashkevich, V.N, Toro, R, Ramagopal, U, Sauder, J.M, Schwinn, K.D, Thompson, D.A, Rutter, M.E, Dickey, M, Groshong, C, Bain, K.T, Adams, J.M, Reyes, C, Rooney, I, Powell, A, Boice, A, Gheyi, T, Ozyurt, S, Atwell, S, Wasserman, S.R, Emtage, S, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | 登録日 | 2006-06-28 | 公開日 | 2006-08-29 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural genomics of protein phosphatases. J.STRUCT.FUNCT.GENOM., 8, 2007
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1XUR
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![BU of 1xur by Molmil](/molmil-images/mine/1xur) | Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor | 分子名称: | CALCIUM ION, Collagenase 3, N,N'-BIS(PYRIDIN-3-YLMETHYL)PYRIMIDINE-4,6-DICARBOXAMIDE, ... | 著者 | Engel, C.K, Wendt, K.U. | 登録日 | 2004-10-26 | 公開日 | 2005-10-26 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural basis for the highly selective inhibition of MMP-13. Chem.Biol., 12, 2005
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2I1Y
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![BU of 2i1y by Molmil](/molmil-images/mine/2i1y) | Crystal structure of the phosphatase domain of human PTP IA-2 | 分子名称: | GLYCEROL, Receptor-type tyrosine-protein phosphatase | 著者 | Faber-Barata, J, Patskovsky, Y, Alvarado, J, Smith, D, Koss, J, Wasserman, S.R, Ozyurt, S, Atwell, S, Powell, A, Kearins, M.C, Maletic, M, Rooney, I, Bain, K.T, Freeman, M, Russell, J.C, Thompson, D.A, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | 登録日 | 2006-08-15 | 公開日 | 2006-08-29 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Structural genomics of protein phosphatases J.STRUCT.FUNCT.GENOM., 8, 2007
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2HY3
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![BU of 2hy3 by Molmil](/molmil-images/mine/2hy3) | Crystal structure of the human tyrosine receptor phosphate gamma in complex with vanadate | 分子名称: | Receptor-type tyrosine-protein phosphatase gamma, VANADATE ION | 著者 | Jin, X, Min, T, Bera, A, Mu, H, Sauder, J.M, Freeman, J.C, Reyes, C, Smith, D, Wasserman, S.R, Burley, S.K, Shapiro, L, New York SGX Research Center for Structural Genomics (NYSGXRC) | 登録日 | 2006-08-04 | 公開日 | 2006-09-05 | 最終更新日 | 2021-02-03 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural genomics of protein phosphatases. J.STRUCT.FUNCT.GENOM., 8, 2007
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3PF3
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![BU of 3pf3 by Molmil](/molmil-images/mine/3pf3) | Crystal structure of a mutant (C202A) of Triosephosphate isomerase from Giardia lamblia derivatized with MMTS | 分子名称: | CALCIUM ION, GLYCEROL, SULFATE ION, ... | 著者 | Enriquez-Flores, S, Rodriguez-Romero, A, Hernandez-Santoyo, A, Reyes-Vivas, H. | 登録日 | 2010-10-27 | 公開日 | 2011-06-22 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.098 Å) | 主引用文献 | Determining the molecular mechanism of inactivation by chemical modification of triosephosphate isomerase from the human parasite Giardia lamblia: A study for antiparasitic drug design. Proteins, 79, 2011
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2L0X
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![BU of 2l0x by Molmil](/molmil-images/mine/2l0x) | Solution structure of the 21 kDa GTPase RHEB bound to GDP | 分子名称: | GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | 著者 | Stoll, R, Heumann, R, Berghaus, C, Kock, G. | 登録日 | 2010-07-19 | 公開日 | 2010-08-04 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Ras homolog enriched in brain (Rheb) enhances apoptotic signaling. J.Biol.Chem., 285, 2010
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3CEK
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![BU of 3cek by Molmil](/molmil-images/mine/3cek) | Crystal structure of human dual specificity protein kinase (TTK) | 分子名称: | 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, Dual specificity protein kinase TTK | 著者 | Filippakopoulos, P, Soundararajan, M, Keates, T, Elkins, J.M, King, O, Fedorov, O, Picaud, S.S, Pike, A.C.W, Roos, A, Pilka, E, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2008-02-29 | 公開日 | 2008-03-18 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat.Chem.Biol., 6, 2010
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1XYX
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![BU of 1xyx by Molmil](/molmil-images/mine/1xyx) | mouse prion protein fragment 121-231 | 分子名称: | Major prion protein | 著者 | Gossert, A.D, Bonjour, S, Lysek, D.A, Fiorito, F, Wuthrich, K. | 登録日 | 2004-11-11 | 公開日 | 2004-11-28 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Prion protein NMR structures of elk and of mouse/elk hybrids Proc.Natl.Acad.Sci.USA, 102, 2005
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3P2B
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![BU of 3p2b by Molmil](/molmil-images/mine/3p2b) | Crystal Structure of PI3K gamma with 3-(2-morpholino-6-(pyridin-3-ylamino)pyrimidin-4-yl)phenol | 分子名称: | 3-[2-morpholin-4-yl-6-(pyridin-3-ylamino)pyrimidin-4-yl]phenol, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 著者 | Knapp, M.S, Elling, R.A, Ornelas, E. | 登録日 | 2010-10-01 | 公開日 | 2011-08-17 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Identification and structure-activity relationship of 2-morpholino 6-(3-hydroxyphenyl) pyrimidines, a class of potent and selective PI3 kinase inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
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1WV0
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![BU of 1wv0 by Molmil](/molmil-images/mine/1wv0) | Crystallographic studies on acyl ureas, a new class of inhibitors of glycogen phosphorylase. Broad specificity of the allosteric site | 分子名称: | 4-[4-({[(2,4-DICHLOROBENZOYL)AMINO]CARBONYL}AMINO)-2,3-DIMETHYLPHENOXY]BUTANOIC ACID, Glycogen phosphorylase, muscle form, ... | 著者 | Oikonomakos, N.G, Kosmopoulou, M.N, Chrysina, E.D, Leonidas, D.D, Klabunde, T, Wendt, K.U, Defossa, E. | 登録日 | 2004-12-10 | 公開日 | 2005-12-10 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs Protein Sci., 14, 2005
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1WV1
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![BU of 1wv1 by Molmil](/molmil-images/mine/1wv1) | Crystallographic studies on acyl ureas, a new class of inhibitors of glycogenphosphorylase. Broad specificity of the allosteric site | 分子名称: | 5-[3-({[(2,4-DICHLOROBENZOYL)AMINO]CARBONYL}AMINO)-2-METHYLPHENOXY]PENTANOIC ACID, Glycogen phosphorylase, muscle form, ... | 著者 | Oikonomakos, N.G, Kosmopoulou, M.N, Chrysina, E.D, Leonidas, D.D, Klabunde, T, Wendt, K.U, Defossa, E. | 登録日 | 2004-12-10 | 公開日 | 2005-12-10 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs Protein Sci., 14, 2005
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1WUY
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![BU of 1wuy by Molmil](/molmil-images/mine/1wuy) | Crystallographic studies on acyl ureas, a new class of inhibitors of glycogen phosphorylase. Broad specificity of the allosteric site | 分子名称: | 4-[3-CHLORO-4-({[(2,4-DICHLOROBENZOYL)AMINO]CARBONYL}AMINO)PHENOXY]BUTANOIC ACID, Glycogen phosphorylase, muscle form, ... | 著者 | Oikonomakos, N.G, Kosmopoulou, M.N, Chrysina, E.D, Leonidas, D.D, Klabunde, T, Wendt, K.U, Defossa, E. | 登録日 | 2004-12-09 | 公開日 | 2005-12-09 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs Protein Sci., 14, 2005
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3KFO
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![BU of 3kfo by Molmil](/molmil-images/mine/3kfo) | Crystal structure of the C-terminal domain from the nuclear pore complex component NUP133 from Saccharomyces cerevisiae | 分子名称: | GLYCEROL, Nucleoporin NUP133 | 著者 | Sampathkumar, P, Bonanno, J.B, Miller, S, Bain, K, Dickey, M, Gheyi, T, Almo, S.C, Rout, M, Sali, A, Phillips, J, Pieper, U, Fernandez-Martinez, J, Franke, J.D, Atwell, S, Thompson, D.A, Emtage, J.S, Wasserman, S, Sauder, J.M, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | 登録日 | 2009-10-27 | 公開日 | 2010-01-26 | 最終更新日 | 2021-02-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure of the C-terminal domain of Saccharomyces cerevisiae Nup133, a component of the nuclear pore complex. Proteins, 79, 2011
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5YJO
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![BU of 5yjo by Molmil](/molmil-images/mine/5yjo) | |
3JTY
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![BU of 3jty by Molmil](/molmil-images/mine/3jty) | Crystal structure of a BenF-like porin from Pseudomonas fluorescens Pf-5 | 分子名称: | BenF-like porin, LAURYL DIMETHYLAMINE-N-OXIDE | 著者 | Sampathkumar, P, Lu, F, Zhao, X, Wasserman, S, Iuzuka, M, Bain, K, Rutter, M, Gheyi, T, Atwell, S, Luz, J, Gilmore, J, Sauder, J.M, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | 登録日 | 2009-09-14 | 公開日 | 2009-10-20 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | Structure of a putative BenF-like porin from Pseudomonas fluorescens Pf-5 at 2.6 A resolution. Proteins, 78, 2010
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4WJV
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![BU of 4wjv by Molmil](/molmil-images/mine/4wjv) | Crystal structure of Rsa4 in complex with the Nsa2 binding peptide | 分子名称: | Maltose-binding periplasmic protein, Ribosome assembly protein 4, Ribosome biogenesis protein NSA2, ... | 著者 | Holdermann, I, Paternoga, H, Bassler, J, Hurt, E, Sinning, I. | 登録日 | 2014-10-01 | 公開日 | 2014-11-19 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation. J.Cell Biol., 207, 2014
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2ISN
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![BU of 2isn by Molmil](/molmil-images/mine/2isn) | Crystal structure of a phosphatase from a pathogenic strain Toxoplasma gondii | 分子名称: | NYSGXRC-8828z, phosphatase, PRASEODYMIUM ION, ... | 著者 | Agarwal, R, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics (NYSGXRC) | 登録日 | 2006-10-18 | 公開日 | 2006-10-31 | 最終更新日 | 2021-02-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural genomics of protein phosphatases. J.STRUCT.FUNCT.GENOM., 8, 2007
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4WJU
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![BU of 4wju by Molmil](/molmil-images/mine/4wju) | Crystal structure of Rsa4 from Saccharomyces cerevisiae | 分子名称: | GLYCEROL, Ribosome assembly protein 4 | 著者 | Holdermann, I, Bassler, J, Hurt, E, Sinning, I. | 登録日 | 2014-10-01 | 公開日 | 2014-11-19 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation. J.Cell Biol., 207, 2014
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5D10
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![BU of 5d10 by Molmil](/molmil-images/mine/5d10) | Kinase domain of cSrc in complex with RL236 | 分子名称: | N-[4-({4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}oxy)phenyl]prop-2-enamide, Proto-oncogene tyrosine-protein kinase Src | 著者 | Becker, C, Mayer-Wrangowski, S.C, Julian, E, Rauh, D. | 登録日 | 2015-08-03 | 公開日 | 2015-09-02 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach. J.Med.Chem., 58, 2015
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