6WUI
 
 | | Crystal Structure of mutant S. pombe Rai1 (E150S/E199Q/E239Q) in complex with 3'-FADP | | 分子名称: | Decapping nuclease din1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)-2,3,4-trihydroxypentyl dihydrogen diphosphate (non-preferred name) | | 著者 | Doamekpor, S.K, Tong, L. | | 登録日 | 2020-05-04 | | 公開日 | 2020-05-20 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs.
Nucleic Acids Res., 48, 2020
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5KS7
 | | Crystal structure of Listeria monocytogenes OpuCA CBS domain dimer in complex with cyclic-di-AMP | | 分子名称: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, Carnitine transport ATP-binding protein OpuCA | | 著者 | Choi, P.H, Tong, L. | | 登録日 | 2016-07-07 | | 公開日 | 2016-07-20 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Cyclic di-AMP targets the cystathionine beta-synthase domain of the osmolyte transporter OpuC.
Mol.Microbiol., 102, 2016
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5KKN
 | | Crystal structure of human ACC2 BC domain in complex with ND-646, the primary amide of ND-630 | | 分子名称: | 2-[1-[(2~{R})-2-(2-methoxyphenyl)-2-(oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-bis(oxidanylidene)thieno[2,3-d]pyrimidin-3-yl]-2-methyl-propanamide, Acetyl-CoA carboxylase 2 | | 著者 | Wang, R, Paul, D, Tong, L. | | 登録日 | 2016-06-22 | | 公開日 | 2016-07-13 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.
Proc.Natl.Acad.Sci.USA, 113, 2016
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6WUF
 | | Crystal structure of mouse DXO in complex with 3'-FADP | | 分子名称: | 1,2-ETHANEDIOL, Decapping and exoribonuclease protein, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)-2,3,4-trihydroxypentyl dihydrogen diphosphate (non-preferred name) | | 著者 | Doamekpor, S.K, Tong, L. | | 登録日 | 2020-05-04 | | 公開日 | 2020-05-20 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs.
Nucleic Acids Res., 48, 2020
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6WRE
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7K95
 | | Crystal structure of human CPSF30 in complex with hFip1 | | 分子名称: | Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4, Pre-mRNA 3'-end-processing factor FIP1, ZINC ION | | 著者 | Hamilton, K, Tong, L. | | 登録日 | 2020-09-28 | | 公開日 | 2020-11-11 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Molecular mechanism for the interaction between human CPSF30 and hFip1.
Genes Dev., 34, 2020
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5KXF
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5KS8
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6X7V
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6X7U
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4FGM
 | | Crystal structure of the aminopeptidase N family protein Q5QTY1 from Idiomarina loihiensis. Northeast Structural Genomics Consortium Target IlR60. | | 分子名称: | Aminopeptidase N family protein, MALEIC ACID, ZINC ION | | 著者 | Vorobiev, S, Su, M, Tong, T, Kohan, E, Wang, D, Everett, J.K, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2012-06-04 | | 公開日 | 2012-08-01 | | 最終更新日 | 2017-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.394 Å) | | 主引用文献 | Crystal structure of the aminopeptidase N family protein Q5QTY1 from Idiomarina loihiensis.
To be Published
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1IEG
 | | CRYSTAL STRUCTURE OF THE CATALYTIC SITE MUTANT S134A/H157A OF THE HUMAN CYTOMEGALOVIRUS PROTEASE | | 分子名称: | CAPSID PROTEIN P40: ASSEMBLIN PROTEASE | | 著者 | Khayat, R, Batra, R, Massariol, M.J, Lagace, L, Tong, L. | | 登録日 | 2001-04-09 | | 公開日 | 2001-06-06 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Investigating the role of histidine 157 in the catalytic activity of human cytomegalovirus protease.
Biochemistry, 40, 2001
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1IEF
 | | CRYSTAL STRUCTURE OF THE CATALYTIC SITE MUTANT S134A OF THE HUMAN CYTOMEGALOVIRUS PROTEASE | | 分子名称: | CAPSID PROTEIN P40: ASSEMBLIN PROTEASE | | 著者 | Khayat, R, Batra, R, Massariol, M.J, Lagace, L, Tong, L. | | 登録日 | 2001-04-09 | | 公開日 | 2001-06-06 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Investigating the role of histidine 157 in the catalytic activity of human cytomegalovirus protease.
Biochemistry, 40, 2001
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5BTH
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5BUD
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5BTO
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5BTB
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1ID4
 | | CRYSTAL STRUCTURE OF THE CATALYTIC SITE MUTANT (H157Q) OF THE HUMAN CYTOMEGALOVIRUS PROTEASE | | 分子名称: | CAPSID PROTEIN P40: ASSEMBLIN PROTEASE | | 著者 | Khayat, R, Batra, R, Massariol, M.J, Lagace, L, Tong, L. | | 登録日 | 2001-04-03 | | 公開日 | 2001-06-06 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Investigating the role of histidine 157 in the catalytic activity of human cytomegalovirus protease.
Biochemistry, 40, 2001
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1KV1
 | | p38 MAP Kinase in Complex with Inhibitor 1 | | 分子名称: | 1-(5-TERT-BUTYL-2-METHYL-2H-PYRAZOL-3-YL)-3-(4-CHLORO-PHENYL)-UREA, p38 MAP kinase | | 著者 | Pargellis, C, Tong, L, Churchill, L, Cirillo, P.F, Gilmore, T, Graham, A.G, Grob, P.M, Hickey, E.R, Moss, N, Pav, S, Regan, J. | | 登録日 | 2002-01-23 | | 公開日 | 2002-03-27 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site.
Nat.Struct.Biol., 9, 2002
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1KV2
 | | Human p38 MAP Kinase in Complex with BIRB 796 | | 分子名称: | 1-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-3-[4-(2-MORPHOLIN-4-YL-ETHOXY)-NAPHTHALEN-1-YL]-UREA, p38 MAP kinase | | 著者 | Pargellis, C, Tong, L, Churchill, L, Cirillo, P.F, Gilmore, T, Graham, A.G, Grob, P.M, Hickey, E.R, Moss, N, Pav, S, Regan, J. | | 登録日 | 2002-01-23 | | 公開日 | 2002-03-27 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site.
Nat.Struct.Biol., 9, 2002
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5CS4
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5CS0
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5CSK
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5CSA
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5CSL
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