7ZAK
 
 | | Crystal structure of HLA-DP (DPA1*02:01-DPB1*01:01) in complex with a peptide | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Racle, J, Guillaume, P, Larabi, A, Lau, K, Pojer, F, Gfeller, D. | | 登録日 | 2022-03-22 | | 公開日 | 2023-03-29 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | | 主引用文献 | Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes.
Immunity, 56, 2023
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8B0F
 | | CryoEM structure of C5b8-CD59 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Bubeck, D, Couves, E.C, Gardner, S. | | 登録日 | 2022-09-07 | | 公開日 | 2023-02-22 | | 最終更新日 | 2023-03-01 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis for membrane attack complex inhibition by CD59.
Nat Commun, 14, 2023
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8AKK
 | | Acyl-enzyme complex of imipenem bound to deacylation mutant KPC-2 (E166Q) | | 分子名称: | (2R,4S)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-[(2-{[(Z)-iminomethyl]amino}ethyl)sulfanyl]-3,4-dihydro-2H-pyrrole-5-ca rboxylic acid, Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, ... | | 著者 | Tooke, C.L, Hinchliffe, P, Spencer, J. | | 登録日 | 2022-07-29 | | 公開日 | 2023-03-08 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | | 主引用文献 | Tautomer-Specific Deacylation and Omega-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 beta-Lactamase.
J.Am.Chem.Soc., 145, 2023
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8AKM
 | | Acyl-enzyme complex of ertapenem bound to deacylation mutant KPC-2 (E166Q) | | 分子名称: | Carbapenem-hydrolyzing beta-lactamase KPC, Ertapenem, GLYCEROL, ... | | 著者 | Tooke, C.L, Hinchliffe, P, Spencer, J. | | 登録日 | 2022-07-29 | | 公開日 | 2023-03-08 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Tautomer-Specific Deacylation and Omega-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 beta-Lactamase.
J.Am.Chem.Soc., 145, 2023
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8AKJ
 | | Acyl-enzyme complex of cephalothin bound to deacylation mutant KPC-2 (E166Q) | | 分子名称: | 5-METHYLENE-2-[2-OXO-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-ETHYL]-5,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID, Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, ... | | 著者 | Tooke, C.L, Hinchliffe, P, Spencer, J. | | 登録日 | 2022-07-29 | | 公開日 | 2023-03-08 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Tautomer-Specific Deacylation and Omega-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 beta-Lactamase.
J.Am.Chem.Soc., 145, 2023
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8PXI
 | | Crystal structure of Endothiapepsin soaked with FRG283 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-(2-{[methyl(prop-2-yn-1-yl)amino]methyl}-1,3-thiazol-4-yl)piperidin-4-ol, DIMETHYL SULFOXIDE, ... | | 著者 | Mueller, J.M, Eckelt, S, Klebe, G, Glinca, S. | | 登録日 | 2023-07-23 | | 公開日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Crystal structures of Endothiapepsin with ligands derived from merged fragment hits
To Be Published
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8QI7
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8R61
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8QB7
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8QBD
 | | Helical reconstruction of yeast eisosome protein Pil1 bound to membrane composed of lipid mixture +PIP2/+sterol (DOPC, DOPE, DOPS, cholesterol, PI(4,5)P2 35:20:20:15:10) | | 分子名称: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine, Sphingolipid long chain base-responsive protein PIL1 | | 著者 | Kefauver, J.M, Zou, L, Desfosses, A, Loewith, R.J. | | 登録日 | 2023-08-24 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-08-28 | | 実験手法 | ELECTRON MICROSCOPY (3.61 Å) | | 主引用文献 | Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain.
Nature, 632, 2024
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8QBF
 | | Compact state - Pil1 dimer with lipid headgroups fitted in native eisosome lattice bound to plasma membrane microdomain | | 分子名称: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, PHOSPHOSERINE, Sphingolipid long chain base-responsive protein PIL1 | | 著者 | Kefauver, J.M, Zou, L, Desfosses, A, Loewith, R.J. | | 登録日 | 2023-08-24 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-08-28 | | 実験手法 | ELECTRON MICROSCOPY (3.67 Å) | | 主引用文献 | Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain.
Nature, 632, 2024
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8QBG
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8QBE
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8QB8
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8RZC
 | | SARS-CoV-2 nsp16-nsp10 in complex with SAM derivative inhibitor 11 | | 分子名称: | 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanylmethyl]-5-imidazol-1-yl-benzoic acid, ... | | 著者 | Kalnins, G. | | 登録日 | 2024-02-12 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-10-02 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structural basis for inhibition of the SARS-CoV-2 nsp16 by substrate-based dual site inhibitors.
Chemmedchem, 2024
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8RZD
 | | SARS-CoV-2 nsp16-nsp10 in complex with SAM derivative inhibitor 9 | | 分子名称: | 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanylmethyl]-5-(3-hydroxyphenyl)benzoic acid, ... | | 著者 | Kalnins, G. | | 登録日 | 2024-02-12 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-10-02 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural basis for inhibition of the SARS-CoV-2 nsp16 by substrate-based dual site inhibitors.
Chemmedchem, 2024
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8RZE
 | | SARS-CoV-2 nsp16-nsp10 in complex with SAM derivative inhibitor 10 | | 分子名称: | 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanylmethyl]-5-pyridin-3-yl-benzoic acid, ... | | 著者 | Kalnins, G. | | 登録日 | 2024-02-12 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-10-02 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis for inhibition of the SARS-CoV-2 nsp16 by substrate-based dual site inhibitors.
Chemmedchem, 2024
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8S8A
 | | Human pyridoxal phosphatase in complex with 7,8-dihydroxyflavone without phosphate | | 分子名称: | 7,8-bis(oxidanyl)-2-phenyl-chromen-4-one, CHLORIDE ION, Chronophin, ... | | 著者 | Brenner, M, Gohla, A, Schindelin, H. | | 登録日 | 2024-03-06 | | 公開日 | 2024-06-12 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | 7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase.
Elife, 13, 2024
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8S0B
 | | H. sapiens MCM bound to double stranded DNA and ORC6 as part of the MCM-ORC complex | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (45-mer), DNA replication licensing factor MCM2, ... | | 著者 | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | | 登録日 | 2024-02-13 | | 公開日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | MCM Double Hexamer Loading Visualised with Human Proteins
Nature, 2024
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8S0F
 | | H. sapiens OC1M bound to double stranded DNA | | 分子名称: | DNA (39-mer), DNA replication factor Cdt1, DNA replication licensing factor MCM2, ... | | 著者 | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | | 登録日 | 2024-02-13 | | 公開日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | MCM Double Hexamer Loading Visualised with Human Proteins
Nature, 2024
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8S0A
 | | H. sapiens MCM2-7 hexamer bound to double stranded DNA | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (22-mer), ... | | 著者 | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | | 登録日 | 2024-02-13 | | 公開日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | MCM Double Hexamer Loading Visualised with Human Proteins
Nature, 2024
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8S0D
 | | H. sapiens MCM bound to double stranded DNA and ORC1-6 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (58-mer), DNA replication licensing factor MCM2, ... | | 著者 | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | | 登録日 | 2024-02-13 | | 公開日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | MCM Double Hexamer Loading Visualised with Human Proteins
Nature, 2024
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8S0C
 | | H. sapiens ORC1-5 bound to double stranded DNA as part of the MCM-ORC complex | | 分子名称: | DNA (26-mer), Isoform 2 of Origin recognition complex subunit 3, MAGNESIUM ION, ... | | 著者 | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | | 登録日 | 2024-02-13 | | 公開日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | MCM Double Hexamer Loading Visualised with Human Proteins
Nature, 2024
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8S0E
 | | H. sapiens OCCM bound to double stranded DNA | | 分子名称: | Cell division control protein 6 homolog, DNA (39-mer), DNA replication factor Cdt1, ... | | 著者 | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | | 登録日 | 2024-02-13 | | 公開日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | MCM Double Hexamer Loading Visualised with Human Proteins
Nature, 2024
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8S09
 | | H. sapiens MCM2-7 double hexamer bound to double stranded DNA | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (45-mer), ... | | 著者 | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | | 登録日 | 2024-02-13 | | 公開日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | MCM Double Hexamer Loading Visualised with Human Proteins
Nature, 2024
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