7T9U
 
 | | Crystal structure of hSTING with an agonist (SHR169224) | | 分子名称: | (3S,4S)-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-4-(prop-2-en-1-yl)-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine-8-carboxamide, CALCIUM ION, Stimulator of interferon genes protein | | 著者 | Chowdhury, R, Miller, M. | | 登録日 | 2021-12-20 | | 公開日 | 2022-12-21 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis.
Sci Rep, 12, 2022
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4NSC
 | | Crystal Structure of CBARA1 in the Apo-form | | 分子名称: | Calcium uptake protein 1, mitochondrial | | 著者 | Wang, L, Yang, X, Li, S, Shen, Y. | | 登録日 | 2013-11-28 | | 公開日 | 2014-02-26 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake.
Embo J., 33, 2014
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4NSD
 | | Crystal Structure of CBARA1 in the Ca2+ Binding Form | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Wang, L, Yang, X, Li, S, Shen, Y. | | 登録日 | 2013-11-28 | | 公開日 | 2014-02-26 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake.
Embo J., 33, 2014
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8C15
 | | Aurora A kinase in complex with TPX2-inhibitor 3 | | 分子名称: | (1~{R},2~{R})-cyclohexane-1,2-dicarboxylic acid, 4-(4-chlorophenyl)-1~{H}-indole-6-carboxylic acid, ACETATE ION, ... | | 著者 | Fischer, G, Rocaboy, M, Blaszczyk, B, Moschetti, T, Wang, X, Scott, D.E, Coyne, A.G, Dagostin, C, Rooney, T, Bayly, A, Feng, J, Asteian, A, Alcaide-Lopez, A, Stockwell, S, Skidmore, J, Venkitaraman, A.R, Abell, C, Blundell, T.L, Hyvonen, M. | | 登録日 | 2022-12-20 | | 公開日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agents
To be published
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7DL3
 | | The structure of 3,5-DAHDHcca complex with NADPH | | 分子名称: | 3,5-diaminohexanoate dehydrogenase, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Liu, N, Wu, L, Zhu, D.M, Zhou, J.H. | | 登録日 | 2020-11-25 | | 公開日 | 2021-09-29 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.84606934 Å) | | 主引用文献 | Crystal Structures and Catalytic Mechanism of l-erythro-3,5-Diaminohexanoate Dehydrogenase and Rational Engineering for Asymmetric Synthesis of beta-Amino Acids.
Angew.Chem.Int.Ed.Engl., 60, 2021
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7DL7
 | | The wild-type structure of 3,5-DAHDHcca | | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3,5-diaminohexanoate dehydrogenase, ... | | 著者 | Liu, N, Wu, L, Zhu, D.M, Zhou, J.H. | | 登録日 | 2020-11-26 | | 公開日 | 2021-09-29 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.30065823 Å) | | 主引用文献 | Crystal Structures and Catalytic Mechanism of l-erythro-3,5-Diaminohexanoate Dehydrogenase and Rational Engineering for Asymmetric Synthesis of beta-Amino Acids.
Angew.Chem.Int.Ed.Engl., 60, 2021
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7DL0
 | | The mutant E310G/A314Y of 3,5-DAHDHcca complex with NADPH | | 分子名称: | 1,2-ETHANEDIOL, 3,5-diaminohexanoate dehydrogenase, CHLORIDE ION, ... | | 著者 | Liu, N, Wu, L, Zhu, D.M, Zhou, J.H. | | 登録日 | 2020-11-25 | | 公開日 | 2021-09-29 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Crystal Structures and Catalytic Mechanism of l-erythro-3,5-Diaminohexanoate Dehydrogenase and Rational Engineering for Asymmetric Synthesis of beta-Amino Acids.
Angew.Chem.Int.Ed.Engl., 60, 2021
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7DL1
 | | The mutant E310G/G323S structure of 3,5-DAHDHcca complex with NADPH | | 分子名称: | 3,5-diaminohexanoate dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Liu, N, Wu, L, Zhu, D.M, Zhou, J.H. | | 登録日 | 2020-11-25 | | 公開日 | 2021-09-29 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | | 主引用文献 | Crystal Structures and Catalytic Mechanism of l-erythro-3,5-Diaminohexanoate Dehydrogenase and Rational Engineering for Asymmetric Synthesis of beta-Amino Acids.
Angew.Chem.Int.Ed.Engl., 60, 2021
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7EJJ
 | | Crystal structure of KRED F147L/L153Q/Y190P variant and methyl methacrylate complex | | 分子名称: | 3-alpha-(Or 20-beta)-hydroxysteroid dehydrogenase, MAGNESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Cui, J, Huang, X, Wang, B, Zhao, H, Zhou, J. | | 登録日 | 2021-04-02 | | 公開日 | 2022-05-11 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.80000663 Å) | | 主引用文献 | Photoinduced chemomimetic biocatalysis for enantioselective intermolecular radical conjugate addition
Nat Catal, 2022
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7EJH
 | | Crystal structure of KRED mutant-F147L/L153Q/Y190P/L199A/M205F/M206F and 2-hydroxyisoindoline-1,3-dione complex | | 分子名称: | 2-oxidanylisoindole-1,3-dione, 3-alpha-(Or 20-beta)-hydroxysteroid dehydrogenase, MAGNESIUM ION, ... | | 著者 | Cui, J, Huang, X, Wang, B, Zhao, H, Zhou, J. | | 登録日 | 2021-04-02 | | 公開日 | 2022-05-11 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.72883928 Å) | | 主引用文献 | Photoinduced chemomimetic biocatalysis for enantioselective intermolecular radical conjugate addition
Nat Catal, 2022
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7EJI
 | | Crystal structure of KRED F147L/L153Q/Y190P/L199A/M205F/M206F variant and methyl methacrylate complex | | 分子名称: | 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-oxidanylisoindole-1,3-dione, ... | | 著者 | Cui, J, Huang, X, Wang, B, Zhao, H, Zhou, J. | | 登録日 | 2021-04-02 | | 公開日 | 2022-05-11 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.560016 Å) | | 主引用文献 | Photoinduced chemomimetic biocatalysis for enantioselective intermolecular radical conjugate addition
Nat Catal, 2022
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7CSD
 | | AtPrR1 with NADP+ and (+)lariciresinol | | 分子名称: | 4-[[(3R,4R,5S)-4-(hydroxymethyl)-5-(3-methoxy-4-oxidanyl-phenyl)oxolan-3-yl]methyl]-2-methoxy-phenol, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pinoresinol reductase 1 | | 著者 | Shao, K, Zhang, P. | | 登録日 | 2020-08-14 | | 公開日 | 2021-06-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.79709971 Å) | | 主引用文献 | Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.
Nat Commun, 12, 2021
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7CS2
 | | Apo structure of dimeric IiPLR1 | | 分子名称: | Pinoresinol-lariciresinol reductase | | 著者 | Shao, K, Zhang, P. | | 登録日 | 2020-08-14 | | 公開日 | 2021-06-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.68800473 Å) | | 主引用文献 | Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.
Nat Commun, 12, 2021
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7CSE
 | | AtPrR1 with NADP+ and (-)lariciresinol | | 分子名称: | 4-[[(3S,4S,5R)-4-(hydroxymethyl)-5-(3-methoxy-4-oxidanyl-phenyl)oxolan-3-yl]methyl]-2-methoxy-phenol, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pinoresinol reductase 1 | | 著者 | Shao, K, Zhang, P. | | 登録日 | 2020-08-14 | | 公開日 | 2021-06-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.44019055 Å) | | 主引用文献 | Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.
Nat Commun, 12, 2021
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7CS4
 | | IiPLR1 with NADP+ and (+)pinoresinol | | 分子名称: | 4-[(3S,3aR,6S,6aR)-6-(3-methoxy-4-oxidanyl-phenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxy-phenol, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pinoresinol-lariciresinol reductase | | 著者 | Shao, K, Zhang, P. | | 登録日 | 2020-08-14 | | 公開日 | 2021-06-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.30509257 Å) | | 主引用文献 | Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.
Nat Commun, 12, 2021
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7CS6
 | | IiPLR1 with NADP+ and (-)lariciresinol | | 分子名称: | 4-[[(3S,4S,5R)-4-(hydroxymethyl)-5-(3-methoxy-4-oxidanyl-phenyl)oxolan-3-yl]methyl]-2-methoxy-phenol, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pinoresinol-lariciresinol reductase | | 著者 | Shao, K, Zhang, P. | | 登録日 | 2020-08-14 | | 公開日 | 2021-06-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.20139647 Å) | | 主引用文献 | Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.
Nat Commun, 12, 2021
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7CS8
 | | IiPLR1 with NADP+ and (-)secoisolariciresinol | | 分子名称: | (2R,3R)-2,3-bis[(3-methoxy-4-oxidanyl-phenyl)methyl]butane-1,4-diol, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pinoresinol-lariciresinol reductase | | 著者 | Shao, K, Zhang, P. | | 登録日 | 2020-08-14 | | 公開日 | 2021-06-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.60003257 Å) | | 主引用文献 | Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.
Nat Commun, 12, 2021
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7CSB
 | | AtPrR1 with NADP+ and (+)pinoresinol | | 分子名称: | 4-[(3S,3aR,6S,6aR)-6-(3-methoxy-4-oxidanyl-phenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxy-phenol, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pinoresinol reductase 1 | | 著者 | Shao, K, Zhang, P. | | 登録日 | 2020-08-14 | | 公開日 | 2021-06-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.002017 Å) | | 主引用文献 | Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.
Nat Commun, 12, 2021
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7CSH
 | | AtPrR2 with NADP+ and (+)pinoresinol | | 分子名称: | 4-[(3S,3aR,6S,6aR)-6-(3-methoxy-4-oxidanyl-phenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxy-phenol, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pinoresinol reductase 2 | | 著者 | Shao, K, Zhang, P. | | 登録日 | 2020-08-14 | | 公開日 | 2021-06-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.590775 Å) | | 主引用文献 | Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.
Nat Commun, 12, 2021
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7CS7
 | | IiPLR1 with NADP+ and (+)secoisolariciresinol | | 分子名称: | (2S,3S)-2,3-bis[(3-methoxy-4-oxidanyl-phenyl)methyl]butane-1,4-diol, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pinoresinol-lariciresinol reductase | | 著者 | Shao, K, Zhang, P. | | 登録日 | 2020-08-14 | | 公開日 | 2021-06-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.297653 Å) | | 主引用文献 | Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.
Nat Commun, 12, 2021
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7CSF
 | | AtPrR1 with NADP+ and (-)secoisolariciresinol | | 分子名称: | (2R,3R)-2,3-bis[(3-methoxy-4-oxidanyl-phenyl)methyl]butane-1,4-diol, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pinoresinol reductase 1 | | 著者 | Shao, K, Zhang, P. | | 登録日 | 2020-08-14 | | 公開日 | 2021-06-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.98241806 Å) | | 主引用文献 | Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.
Nat Commun, 12, 2021
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7CS3
 | | IiPLR1 with NADP+ | | 分子名称: | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pinoresinol-lariciresinol reductase | | 著者 | Shao, K, Zhang, P. | | 登録日 | 2020-08-14 | | 公開日 | 2021-06-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.40021849 Å) | | 主引用文献 | Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.
Nat Commun, 12, 2021
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7CS9
 | | AtPrR1 in apo form | | 分子名称: | Pinoresinol reductase 1 | | 著者 | Shao, K, Zhang, P. | | 登録日 | 2020-08-14 | | 公開日 | 2021-06-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.8011415 Å) | | 主引用文献 | Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.
Nat Commun, 12, 2021
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7CSG
 | | AtPrR2 in apo form | | 分子名称: | Pinoresinol reductase 2 | | 著者 | Shao, K, Zhang, P. | | 登録日 | 2020-08-14 | | 公開日 | 2021-06-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.99689388 Å) | | 主引用文献 | Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.
Nat Commun, 12, 2021
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7CSC
 | | AtPrR1 with NADP+ and (-)pinoresinol | | 分子名称: | 4-[(3R,3aS,6R,6aS)-6-(3-methoxy-4-oxidanyl-phenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxy-phenol, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pinoresinol reductase 1 | | 著者 | Shao, K, Zhang, P. | | 登録日 | 2020-08-14 | | 公開日 | 2021-06-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.5151186 Å) | | 主引用文献 | Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.
Nat Commun, 12, 2021
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