3KLG
| Crystal structure of AZT-resistant HIV-1 Reverse Transcriptase crosslinked to pre-translocation AZTMP-Terminated DNA (COMPLEX N) | 分子名称: | DNA (5'-D(*A*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*AP*(ATM))-3'), DNA (5'-D(*AP*T*GP*CP*AP*TP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3'), Reverse transcriptase/ribonuclease H, ... | 著者 | Tu, X, Sarafianos, S.G, Arnold, E. | 登録日 | 2009-11-07 | 公開日 | 2010-09-22 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.65 Å) | 主引用文献 | Structural basis of HIV-1 resistance to AZT by excision. Nat.Struct.Mol.Biol., 17, 2010
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3KLH
| Crystal structure of AZT-Resistant HIV-1 Reverse Transcriptase crosslinked to post-translocation AZTMP-Terminated DNA (COMPLEX P) | 分子名称: | DNA (5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(ATM))-3'), DNA (5'-D(*AP*T*GP*CP*TP*AP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3'), MAGNESIUM ION, ... | 著者 | Tu, X, Sarafianos, S.G, Arnold, E. | 登録日 | 2009-11-07 | 公開日 | 2010-09-22 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural basis of HIV-1 resistance to AZT by excision. Nat.Struct.Mol.Biol., 17, 2010
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2I5J
| Crystal structure of HIV-1 reverse transcriptase (RT) in complex with DHBNH, an RNASE H inhibitor | 分子名称: | (E)-3,4-DIHYDROXY-N'-[(2-METHOXYNAPHTHALEN-1-YL)METHYLENE]BENZOHYDRAZIDE, MAGNESIUM ION, Reverse transcriptase/ribonuclease H P51 subunit, ... | 著者 | Himmel, D.M, Sarafianos, S.G, Knight, J.L, Levy, R.M, Arnold, E. | 登録日 | 2006-08-24 | 公開日 | 2006-12-05 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site. Acs Chem.Biol., 1, 2006
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8Y6U
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1HPZ
| HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 | 分子名称: | ALPHA-(2,6-DICHLOROPHENYL)-ALPHA-(2-ACETYL-5-METHYLANILINO)ACETAMIDE, POL POLYPROTEIN | 著者 | Ding, J, Hsiou, Y, Arnold, E. | 登録日 | 2000-12-13 | 公開日 | 2001-05-30 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance. J.Mol.Biol., 309, 2001
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2HMI
| HIV-1 REVERSE TRANSCRIPTASE/FRAGMENT OF FAB 28/DNA COMPLEX | 分子名称: | DNA (5'-D(*AP*TP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*CP*A)-3'), FAB FRAGMENT OF MONOCLONAL ANTIBODY 28, ... | 著者 | Ding, J, Arnold, E. | 登録日 | 1998-04-10 | 公開日 | 1998-10-14 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution. J.Mol.Biol., 284, 1998
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1CR7
| PEANUT LECTIN-LACTOSE COMPLEX MONOCLINIC FORM | 分子名称: | CALCIUM ION, LECTIN, MANGANESE (II) ION, ... | 著者 | Ravishankar, R, Suguna, K, Surolia, A, Vijayan, M. | 登録日 | 1999-08-14 | 公開日 | 2001-04-21 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structures of the peanut lectin-lactose complex at acidic pH: retention of unusual quaternary structure, empty and carbohydrate bound combining sites, molecular mimicry and crystal packing directed by interactions at the combining site. Proteins, 43, 2001
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1HQE
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1HQU
| HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 | 分子名称: | (S)-4-ISOPROPOXYCARBONYL-6-METHOXY-3-METHYLTHIOMETHYL-3,4-DIHYDROQUINOXALIN-2(1H)-THIONE, POL POLYPROTEIN | 著者 | Hsiou, Y, Ding, J, Arnold, E. | 登録日 | 2000-12-19 | 公開日 | 2001-05-30 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance. J.Mol.Biol., 309, 2001
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2TEP
| PEANUT LECTIN COMPLEXED WITH T-ANTIGENIC DISACCHARIDE | 分子名称: | CALCIUM ION, MANGANESE (II) ION, PROTEIN (PEANUT LECTIN), ... | 著者 | Ravishankar, R, Ravindran, M, Suguna, K, Surolia, A, Vijayan, M. | 登録日 | 1999-04-05 | 公開日 | 1999-04-08 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The Specificity of Peanut Agglutinin for Thomsen-Friedenreich Antigen is Mediated by Water-Bridges Curr.Sci., 72, 1997
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3IG1
| HIV-1 Reverse Transcriptase with the Inhibitor beta-Thujaplicinol Bound at the RNase H Active Site | 分子名称: | 2,7-dihydroxy-4-(propan-2-yl)cyclohepta-2,4,6-trien-1-one, HIV-1 Reverse Transcriptase p51 subunit, HIV-1 Reverse Transcriptase p66 subunit, ... | 著者 | Himmel, D.M, Maegley, K.A, Pauly, T.A, Arnold, E. | 登録日 | 2009-07-27 | 公開日 | 2010-01-26 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site. Structure, 17, 2009
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1QF3
| PEANUT LECTIN COMPLEXED WITH METHYL-BETA-GALACTOSE | 分子名称: | CALCIUM ION, MANGANESE (II) ION, PROTEIN (PEANUT LECTIN), ... | 著者 | Ravishankar, R, Suguna, K, Surolia, A, Vijayan, M. | 登録日 | 1999-04-06 | 公開日 | 1999-07-27 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structures of the complexes of peanut lectin with methyl-beta-galactose and N-acetyllactosamine and a comparative study of carbohydrate binding in Gal/GalNAc-specific legume lectins. Acta Crystallogr.,Sect.D, 55, 1999
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1CQ9
| PEANUT LECTIN-TRICLINIC FORM | 分子名称: | CALCIUM ION, MANGANESE (II) ION, PROTEIN (PEANUT LECTIN) | 著者 | Ravishankar, R, Suguna, K, Surolia, A, Vijayan, M. | 登録日 | 1999-08-06 | 公開日 | 2002-05-01 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Crystal structures of the peanut lectin-lactose complex at acidic pH: retention of unusual
quaternary structure, empty and carbohydrate bound combining sites, molecular mimicry
and crystal packing directed by interactions at the combining site. Proteins, 43, 2001
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3K2P
| HIV-1 Reverse Transcriptase Isolated RnaseH Domain with the Inhibitor beta-thujaplicinol Bound at the Active Site | 分子名称: | 2,7-dihydroxy-4-(propan-2-yl)cyclohepta-2,4,6-trien-1-one, MANGANESE (II) ION, Reverse Transcriptase | 著者 | Pauly, T.A, Himmel, D.M, Maegley, K, Arnold, E. | 登録日 | 2009-09-30 | 公開日 | 2010-02-09 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site. Structure, 17, 2009
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1CIW
| PEANUT LECTIN COMPLEXED WITH N-ACETYLLACTOSAMINE | 分子名称: | CALCIUM ION, MANGANESE (II) ION, PROTEIN (PEANUT LECTIN), ... | 著者 | Ravishankar, R, Suguna, K, Surolia, A, Vijayan, M. | 登録日 | 1999-04-06 | 公開日 | 1999-07-27 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structures of the complexes of peanut lectin with methyl-beta-galactose and N-acetyllactosamine and a comparative study of carbohydrate binding in Gal/GalNAc-specific legume lectins. Acta Crystallogr.,Sect.D, 55, 1999
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3QLH
| HIV-1 Reverse Transcriptase in Complex with Manicol at the RNase H Active Site and TMC278 (Rilpivirine) at the NNRTI Binding Pocket | 分子名称: | (2S)-5,7-dihydroxy-9-methyl-2-(prop-1-en-2-yl)-1,2,3,4-tetrahydro-6H-benzo[7]annulen-6-one, 1,2-ETHANEDIOL, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ... | 著者 | Himmel, D.M, Wojtak, K, Bauman, J.D, Arnold, E. | 登録日 | 2011-02-02 | 公開日 | 2011-12-21 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Synthesis, activity, and structural analysis of novel alpha-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H. J.Med.Chem., 54, 2011
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4QAG
| Structure of a dihydroxycoumarin active-site inhibitor in complex with the RNASE H domain of HIV-1 reverse transcriptase | 分子名称: | (7,8-dihydroxy-2-oxo-2H-chromen-4-yl)acetic acid, MANGANESE (II) ION, Reverse transcriptase/ribonuclease H | 著者 | Himmel, D.M, Ho, W.C, Arnold, E. | 登録日 | 2014-05-04 | 公開日 | 2014-06-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.712 Å) | 主引用文献 | Structure of a Dihydroxycoumarin Active-Site Inhibitor in Complex with the RNase H Domain of HIV-1 Reverse Transcriptase and Structure-Activity Analysis of Inhibitor Analogs. J.Mol.Biol., 426, 2014
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1BZW
| PEANUT LECTIN COMPLEXED WITH C-LACTOSE | 分子名称: | CALCIUM ION, MANGANESE (II) ION, PROTEIN (PEANUT LECTIN), ... | 著者 | Ravishankar, R, Surolia, A, Vijayan, M, Lim, S, Kishi, Y. | 登録日 | 1998-11-05 | 公開日 | 1998-11-11 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Preferred Conformation of C-Lactose at the Free and Peanut Lectin Bound States J.Am.Chem.Soc., 120, 1998
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3GT9
| Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic | 分子名称: | Baculoviral IAP repeat-containing 7, N-{(1S)-1-cyclohexyl-2-[(2S)-2-(4-naphthalen-1-yl-1,3-thiazol-2-yl)pyrrolidin-1-yl]-2-oxoethyl}-N~2~-methyl-L-alaninamide, ZINC ION | 著者 | Franklin, M.C, Fairbrother, W.J, Cohen, F. | 登録日 | 2009-03-27 | 公開日 | 2010-03-09 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres. Bioorg.Med.Chem.Lett., 20, 2010
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3GTA
| Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic | 分子名称: | 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Baculoviral IAP repeat-containing 7, ... | 著者 | Franklin, M.C, Fairbrother, W.J, Cohen, F. | 登録日 | 2009-03-27 | 公開日 | 2010-03-09 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres. Bioorg.Med.Chem.Lett., 20, 2010
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2DVB
| Crystal structure of peanut lectin GAl-beta-1,6-GalNAc complex | 分子名称: | CALCIUM ION, Galactose-binding lectin, MANGANESE (II) ION, ... | 著者 | Natchiar, S.K, Srinivas, O, Mitra, N, Surolia, A, Jayaraman, N, Vijayan, M. | 登録日 | 2006-07-30 | 公開日 | 2006-11-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structural studies on peanut lectin complexed with disaccharides involving different linkages: further insights into the structure and interactions of the lectin ACTA CRYSTALLOGR.,SECT.D, 62, 2006
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2DVF
| Crystals of peanut lectin grown in the presence of GAL-ALPHA-1,3-GAL-BETA-1,4-GAL | 分子名称: | CALCIUM ION, Galactose-binding lectin, MANGANESE (II) ION, ... | 著者 | Natchiar, S.K, Srinivas, O, Mitra, N, Surolia, A, Jayaraman, N, Vijayan, M. | 登録日 | 2006-07-31 | 公開日 | 2006-11-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | Structural studies on peanut lectin complexed with disaccharides involving different linkages: further insights into the structure and interactions of the lectin ACTA CRYSTALLOGR.,SECT.D, 62, 2006
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2DVD
| Crystal structure of peanut lectin GAL-ALPHA-1,3-GAL complex | 分子名称: | CALCIUM ION, Galactose-binding lectin, MANGANESE (II) ION, ... | 著者 | Natchiar, S.K, Srinivas, O, Mitra, N, Surolia, A, Jayaraman, N, Vijayan, M. | 登録日 | 2006-07-31 | 公開日 | 2006-11-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structural studies on peanut lectin complexed with disaccharides involving different linkages: further insights into the structure and interactions of the lectin ACTA CRYSTALLOGR.,SECT.D, 62, 2006
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2DV9
| Crystal structure of peanut lectin GAL-BETA-1,3-GAL complex | 分子名称: | CALCIUM ION, Galactose-binding lectin, MANGANESE (II) ION, ... | 著者 | Natchiar, S.K, Srinivas, O, Mitra, N, Surolia, A, Jayaraman, N, Vijayan, M. | 登録日 | 2006-07-30 | 公開日 | 2006-11-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Structural studies on peanut lectin complexed with disaccharides involving different linkages: further insights into the structure and interactions of the lectin ACTA CRYSTALLOGR.,SECT.D, 62, 2006
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2DVA
| Crystal structure of peanut lectin GAL-BETA-1,3-GALNAC-ALPHA-O-ME (Methyl-T-antigen) complex | 分子名称: | CALCIUM ION, Galactose-binding lectin, MANGANESE (II) ION, ... | 著者 | Natchiar, S.K, Srinivas, O, Mitra, N, Surolia, A, Jayaraman, N, Vijayan, M. | 登録日 | 2006-07-30 | 公開日 | 2006-11-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural studies on peanut lectin complexed with disaccharides involving different linkages: further insights into the structure and interactions of the lectin ACTA CRYSTALLOGR.,SECT.D, 62, 2006
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