3K2P

HIV-1 Reverse Transcriptase Isolated RnaseH Domain with the Inhibitor beta-thujaplicinol Bound at the Active Site

Summary for 3K2P

• Entry DOI: 10.2210/pdb3k2p/pdb
• Descriptor: Reverse Transcriptase, MANGANESE (II) ION, 2,7-dihydroxy-4-(propan-2-yl)cyclohepta-2,4,6-trien-1-one, ... (4 entities in total)
• Functional Keywords: rnase h inhibitor, reverse transcriptase, aids, hiv, protein-inhibitor complex, structure-based drug design, tropolones, tropylium ion, divalent cation chelator, metal-binding, rna-binding, hydrolase
• Biological source: Human immunodeficiency virus type 1 (HIV-1)
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366
• Total number of polymer chains: 2
• Total formula weight: 30490.22

Authors

Pauly, T.A.,Himmel, D.M.,Maegley, K.,Arnold, E. (deposition date: 2009-09-30, release date: 2010-02-09, Last modification date: 2024-02-21)

• Primary citation: Himmel, D.M.,Maegley, K.A.,Pauly, T.A.,Bauman, J.D.,Das, K.,Dharia, C.,Clark, A.D.,Ryan, K.,Hickey, M.J.,Love, R.A.,Hughes, S.H.,Bergqvist, S.,Arnold, E.; Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site.; Structure, 17:1625-1635, 2009; PubMed: 20004166; DOI: 10.1016/j.str.2009.09.016

Experimental method

X-RAY DIFFRACTION (2.04 Å)