5HUV
 
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5HVO
 | | Structure of Aspergillus fumigatus trehalose-6-phosphate synthase B in complex with UDP and validoxylamine A | | 分子名称: | (1S,2S,3R,6S)-4-(HYDROXYMETHYL)-6-{[(1S,2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL]AMINO}CYCLOHEX-4-ENE-1,2,3-TRIOL, Alpha,alpha-trehalose-phosphate synthase (UDP-forming), URIDINE-5'-DIPHOSPHATE | | 著者 | Miao, Y, Brennan, R.G. | | 登録日 | 2016-01-28 | | 公開日 | 2017-05-03 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.467 Å) | | 主引用文献 | Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.
MBio, 8, 2017
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5HJZ
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5HK3
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5HKC
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1JT0
 | | Crystal structure of a cooperative QacR-DNA complex | | 分子名称: | HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION, QACA operator, SULFATE ION | | 著者 | Schumacher, M.A, Miller, M.C, Grkovic, S, Brown, M.H, Skurray, R.A, Brennan, R.G. | | 登録日 | 2001-08-20 | | 公開日 | 2002-03-08 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural basis for cooperative DNA binding by two dimers of the multidrug-binding protein QacR.
EMBO J., 21, 2002
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1JUP
 | | Crystal structure of the multidrug binding transcriptional repressor QacR bound to malachite green | | 分子名称: | HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION, MALACHITE GREEN, SULFATE ION | | 著者 | Schumacher, M.A, Miller, M.C, Grkovic, S, Brown, M.H, Skurray, R.A, Brennan, R.G. | | 登録日 | 2001-08-24 | | 公開日 | 2001-12-12 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Structural mechanisms of QacR induction and multidrug recognition.
Science, 294, 2001
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1KQ1
 | | 1.55 A Crystal structure of the pleiotropic translational regulator, Hfq | | 分子名称: | ACETIC ACID, Host Factor for Q beta | | 著者 | Schumacher, M.A, Pearson, R.F, Moller, T, Valentin-Hansen, P, Brennan, R.G. | | 登録日 | 2002-01-03 | | 公開日 | 2002-07-10 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein.
EMBO J., 21, 2002
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1KQ2
 | | Crystal Structure of an Hfq-RNA Complex | | 分子名称: | 5'-R(*AP*UP*UP*UP*UP*UP*G)-3', Host factor for Q beta | | 著者 | Schumacher, M.A, Pearson, R.F, Moller, T, Valentin-Hansen, P, Brennan, R.G. | | 登録日 | 2002-01-03 | | 公開日 | 2002-07-05 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | | 主引用文献 | Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein.
EMBO J., 21, 2002
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1LIJ
 | | STRUCTURE OF T. GONDII ADENOSINE KINASE BOUND TO PRODRUG 2 7-IODOTUBERCIDIN AND AMP-PCP | | 分子名称: | 2-RIBOFURANOSYL-3-IODO-2,3-DIHYDRO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE, CHLORIDE ION, MAGNESIUM ION, ... | | 著者 | Schumacher, M.A, Scott, D.M, Mathews, I.I, Ealick, S.E, Roos, D.S, Ullman, B, Brennan, R.G. | | 登録日 | 2002-04-17 | | 公開日 | 2002-05-15 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding.
J.Mol.Biol., 298, 2000
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1LIK
 | | STRUCTURE OF T. GONDII ADENOSINE KINASE BOUND TO ADENOSINE | | 分子名称: | ADENOSINE, CHLORIDE ION, SULFATE ION, ... | | 著者 | Schumacher, M.A, Scott, D.M, Mathews, I.I, Ealick, S.E, Roos, D.S, Ullman, B, Brennan, R.G. | | 登録日 | 2002-04-17 | | 公開日 | 2002-05-15 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding.
J.Mol.Biol., 298, 2000
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1LII
 | | STRUCTURE OF T. GONDII ADENOSINE KINASE BOUND TO ADENOSINE 2 AND AMP-PCP | | 分子名称: | ADENOSINE, CHLORIDE ION, MAGNESIUM ION, ... | | 著者 | Schumacher, M.A, Scott, D.M, Mathews, I.I, Ealick, S.E, Roos, D.S, Ullman, B, Brennan, R.G. | | 登録日 | 2002-04-17 | | 公開日 | 2002-05-15 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding.
J.Mol.Biol., 298, 2000
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1LIO
 | | STRUCTURE OF APO T. GONDII ADENOSINE KINASE | | 分子名称: | adenosine kinase | | 著者 | Schumacher, M.A, Scott, D.M, Mathews, I.I, Ealick, S.E, Brennan, R.G. | | 登録日 | 2002-04-17 | | 公開日 | 2002-06-12 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding.
J.Mol.Biol., 298, 2000
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1JFS
 | | PURINE REPRESSOR MUTANT-HYPOXANTHINE-PURF OPERATOR COMPLEX | | 分子名称: | 5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T)-3', HYPOXANTHINE, PURINE NUCLEOTIDE SYNTHESIS REPRESSOR | | 著者 | Huffman, J.L, Lu, F, Zalkin, H, Brennan, R.G. | | 登録日 | 2001-06-21 | | 公開日 | 2002-02-08 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Role of residue 147 in the gene regulatory function of the Escherichia coli purine repressor.
Biochemistry, 41, 2002
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1JBG
 | | Crystal Structure of MtaN, the Bacillus subtilis Multidrug Transporter Activator, N-terminus | | 分子名称: | transcription activator of multidrug-efflux transporter genes mta | | 著者 | Godsey, M.H, Neyfakh, A.A, Brennan, R.G. | | 登録日 | 2001-06-04 | | 公開日 | 2001-11-28 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Crystal structure of MtaN, a global multidrug transporter gene activator.
J.Biol.Chem., 276, 2001
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1JFT
 | | PURINE REPRESSOR MUTANT-HYPOXANTHINE-PURF OPERATOR COMPLEX | | 分子名称: | 5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T)-3', HYPOXANTHINE, PHOSPHATE ION, ... | | 著者 | Huffman, J.L, Lu, F, Zalkin, H, Brennan, R.G. | | 登録日 | 2001-06-21 | | 公開日 | 2002-02-08 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Role of residue 147 in the gene regulatory function of the Escherichia coli purine repressor.
Biochemistry, 41, 2002
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1JTX
 | | Crystal structure of the multidrug binding transcriptional regulator QacR bound to crystal violet | | 分子名称: | CRYSTAL VIOLET, HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION, SULFATE ION | | 著者 | Schumacher, M.A, Miller, M.C, Grkovic, S, Brown, M.H, Skurray, R.A, Brennan, R.G. | | 登録日 | 2001-08-22 | | 公開日 | 2001-12-07 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Structural mechanisms of QacR induction and multidrug recognition.
Science, 294, 2001
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1JLS
 | | STRUCTURE OF THE URACIL PHOSPHORIBOSYLTRANSFERASE URACIL/CPR 2 MUTANT C128V | | 分子名称: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, MAGNESIUM ION, PHOSPHATE ION, ... | | 著者 | Schumacher, M.A, Bashor, C.J, Otsu, K, Zu, S, Parry, R, Ullman, B, Brennan, R.G. | | 登録日 | 2001-07-16 | | 公開日 | 2002-01-16 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | The structural mechanism of GTP stabilized oligomerization and catalytic activation of the Toxoplasma gondii uracil phosphoribosyltransferase.
Proc.Natl.Acad.Sci.USA, 99, 2002
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1JTY
 | | Crystal structure of the multidrug binding transcriptional regulator QacR bound to ethidium | | 分子名称: | ETHIDIUM, HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION, SULFATE ION | | 著者 | Schumacher, M.A, Miller, M.C, Grkovic, S, Brown, M.H, Skurray, R.A, Brennan, R.G. | | 登録日 | 2001-08-22 | | 公開日 | 2001-12-12 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.97 Å) | | 主引用文献 | Structural mechanisms of QacR induction and multidrug recognition.
Science, 294, 2001
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1JHZ
 | | Purine Repressor Mutant Corepressor Binding Domain Structure | | 分子名称: | MAGNESIUM ION, PURINE NUCLEOTIDE SYNTHESIS REPRESSOR | | 著者 | Huffman, J.L, Lu, F, Zalkin, H, Brennan, R.G. | | 登録日 | 2001-06-28 | | 公開日 | 2002-02-08 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Role of residue 147 in the gene regulatory function of the Escherichia coli purine repressor.
Biochemistry, 41, 2002
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1JUM
 | | Crystal structure of the multidrug binding transcriptional repressor QacR bound to the natural drug berberine | | 分子名称: | BERBERINE, HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION, SULFATE ION | | 著者 | Schumacher, M.A, Miller, M.C, Grkovic, S, Brown, M.H, Skurray, R.A, Brennan, R.G. | | 登録日 | 2001-08-24 | | 公開日 | 2001-12-12 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | | 主引用文献 | Structural mechanisms of QacR induction and multidrug recognition.
Science, 294, 2001
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1JH9
 | | PURINE REPRESSOR MUTANT-HYPOXANTHINE-PURF OPERATOR COMPLEX | | 分子名称: | 5'-D(*AP*AP*CP*GP*AP*AP*AP*AP*CP*GP*TP*TP*TP*TP*CP*GP*T)-3', HYPOXANTHINE, PHOSPHATE ION, ... | | 著者 | Huffman, J.L, Lu, F, Zalkin, H, Brennan, R.G. | | 登録日 | 2001-06-27 | | 公開日 | 2002-02-08 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Role of residue 147 in the gene regulatory function of the Escherichia coli purine repressor.
Biochemistry, 41, 2002
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1JUS
 | | Crystal structure of the multidrug binding transcriptional repressor QacR bound to rhodamine 6G | | 分子名称: | HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION, RHODAMINE 6G, SULFATE ION | | 著者 | Schumacher, M.A, Miller, M.C, Grkovic, S, Brown, M.H, Skurray, R.A, Brennan, R.G. | | 登録日 | 2001-08-27 | | 公開日 | 2001-12-12 | | 最終更新日 | 2021-10-27 | | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | | 主引用文献 | Structural mechanisms of QacR induction and multidrug recognition.
Science, 294, 2001
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1JLR
 | | STRUCTURE OF THE URACIL PHOSPHORIBOSYLTRANSFERASE GTP COMPLEX 2 MUTANT C128V | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION, Uracil Phosphoribosyltransferase | | 著者 | Schumacher, M.A, Bashor, C.J, Otsu, K, Zu, S, Parry, R, Ulmman, B, Brennan, R.G. | | 登録日 | 2001-07-16 | | 公開日 | 2002-01-10 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | The structural mechanism of GTP stabilized oligomerization and catalytic activation of the Toxoplasma gondii uracil phosphoribosyltransferase.
Proc.Natl.Acad.Sci.USA, 99, 2002
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1JT6
 | | Crystal structure of the multidrug binding protein QacR bound to dequalinium | | 分子名称: | DEQUALINIUM, Hypothetical transcriptional regulator IN QACA 5'region, SULFATE ION | | 著者 | Schumacher, M.A, Miller, M.C, Grkovic, S, Brown, M.H, Skurray, R.A, Brennan, R.G. | | 登録日 | 2001-08-20 | | 公開日 | 2001-12-12 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | Structural mechanisms of QacR induction and multidrug recognition.
Science, 294, 2001
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