5GXQ
| The crystal structure of the nucleosome containing H3.6 | 分子名称: | DNA (146-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | 著者 | Taguchi, H, Xie, Y, Horikoshi, N, Kurumizaka, H. | 登録日 | 2016-09-19 | 公開日 | 2017-04-19 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Crystal Structure and Characterization of Novel Human Histone H3 Variants, H3.6, H3.7, and H3.8 Biochemistry, 56, 2017
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4EBV
| Structure of Focal Adhesion Kinase catalytic domain in complex with novel allosteric inhibitor | 分子名称: | 8-(4-ethylphenyl)-5-methyl-2,5-dihydropyrazolo[4,3-c][2,1]benzothiazine 4,4-dioxide, Focal adhesion kinase 1, ISOPROPYL ALCOHOL | 著者 | Skene, R.J, Hosfield, D.J. | 登録日 | 2012-03-25 | 公開日 | 2012-08-22 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Discovery and characterization of novel allosteric FAK inhibitors. Eur.J.Med.Chem., 61, 2013
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4OKS
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6RCL
| Crystal structure of REXO2-D199A-AA | 分子名称: | MAGNESIUM ION, Oligoribonuclease, mitochondrial, ... | 著者 | Spahr, H, Nicholls, T.J, Larsson, N.G, Gustafsson, C.M. | 登録日 | 2019-04-11 | 公開日 | 2019-10-09 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria. Mol.Cell, 76, 2019
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5BPA
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5SAK
| Endothiapepsin in complex with compound FU5-1 | 分子名称: | (1Z,3Z)-3-(2-phenylhydrazinylidene)-2,3-dihydro-1H-isoindol-1-imine, DIMETHYL SULFOXIDE, Endothiapepsin, ... | 著者 | Wollenhaupt, J, Metz, A, Messini, N, Barthel, T, Klebe, G, Weiss, M.S. | 登録日 | 2021-05-28 | 公開日 | 2021-09-01 | 最終更新日 | 2021-09-29 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Frag4Lead: growing crystallographic fragment hits by catalog using fragment-guided template docking. Acta Crystallogr D Struct Biol, 77, 2021
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5SAQ
| Endothiapepsin in complex with compound FU58-3 | 分子名称: | 2-({[4-(methylsulfanyl)phenyl]methyl}amino)ethan-1-ol, Endothiapepsin, GLYCEROL | 著者 | Wollenhaupt, J, Metz, A, Messini, N, Barthel, T, Klebe, G, Weiss, M.S. | 登録日 | 2021-05-28 | 公開日 | 2021-09-01 | 最終更新日 | 2021-09-29 | 実験手法 | X-RAY DIFFRACTION (1.02 Å) | 主引用文献 | Frag4Lead: growing crystallographic fragment hits by catalog using fragment-guided template docking. Acta Crystallogr D Struct Biol, 77, 2021
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5SAR
| Endothiapepsin in complex with compound FU290-1 | 分子名称: | (1,4-phenylene)bis(methylene) dicarbamimidothioate, Endothiapepsin | 著者 | Wollenhaupt, J, Metz, A, Messini, N, Barthel, T, Klebe, G, Weiss, M.S. | 登録日 | 2021-05-28 | 公開日 | 2021-09-01 | 最終更新日 | 2021-09-29 | 実験手法 | X-RAY DIFFRACTION (0.98 Å) | 主引用文献 | Frag4Lead: growing crystallographic fragment hits by catalog using fragment-guided template docking. Acta Crystallogr D Struct Biol, 77, 2021
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5SAO
| Endothiapepsin in complex with compound FU58-1 | 分子名称: | 1,2-ETHANEDIOL, 6-[(8R)-2-({[(3,5-dimethyl-1,2-oxazol-4-yl)methyl](methyl)amino}methyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-5(4H)-yl]pyrimidin-4-amine, Endothiapepsin, ... | 著者 | Wollenhaupt, J, Metz, A, Messini, N, Barthel, T, Klebe, G, Weiss, M.S. | 登録日 | 2021-05-28 | 公開日 | 2021-09-01 | 最終更新日 | 2021-09-29 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | Frag4Lead: growing crystallographic fragment hits by catalog using fragment-guided template docking. Acta Crystallogr D Struct Biol, 77, 2021
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5SAL
| Endothiapepsin in complex with compound FU5-2 | 分子名称: | (1Z)-1-imino-1H-isoindol-3-amine, DIMETHYL SULFOXIDE, Endothiapepsin | 著者 | Wollenhaupt, J, Metz, A, Messini, N, Barthel, T, Klebe, G, Weiss, M.S. | 登録日 | 2021-05-28 | 公開日 | 2021-09-01 | 最終更新日 | 2021-09-29 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | Frag4Lead: growing crystallographic fragment hits by catalog using fragment-guided template docking. Acta Crystallogr D Struct Biol, 77, 2021
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5SAT
| Endothiapepsin in complex with compound FU66-1 | 分子名称: | Endothiapepsin, GLYCEROL, N-cyclopropyl-6-(furan-2-yl)-2-hydroxy-N-[(pyridin-2-yl)methyl]pyridine-3-carboxamide | 著者 | Wollenhaupt, J, Metz, A, Messini, N, Barthel, T, Klebe, G, Weiss, M.S. | 登録日 | 2021-05-28 | 公開日 | 2021-09-01 | 最終更新日 | 2021-09-29 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Frag4Lead: growing crystallographic fragment hits by catalog using fragment-guided template docking. Acta Crystallogr D Struct Biol, 77, 2021
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5SAN
| Endothiapepsin in complex with compound FU5-4 | 分子名称: | (2Z)-2-(3-amino-1H-isoindol-1-ylidene)hydrazine-1-carboximidamide, Endothiapepsin, GLYCEROL | 著者 | Wollenhaupt, J, Metz, A, Messini, N, Barthel, T, Klebe, G, Weiss, M.S. | 登録日 | 2021-05-28 | 公開日 | 2021-09-01 | 最終更新日 | 2021-09-29 | 実験手法 | X-RAY DIFFRACTION (0.94 Å) | 主引用文献 | Frag4Lead: growing crystallographic fragment hits by catalog using fragment-guided template docking. Acta Crystallogr D Struct Biol, 77, 2021
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5SAM
| Endothiapepsin in complex with compound FU5-3 | 分子名称: | 3-amino-1H-isoindol-1-one, DIMETHYL SULFOXIDE, Endothiapepsin, ... | 著者 | Wollenhaupt, J, Metz, A, Messini, N, Barthel, T, Klebe, G, Weiss, M.S. | 登録日 | 2021-05-28 | 公開日 | 2021-09-01 | 最終更新日 | 2021-09-29 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Frag4Lead: growing crystallographic fragment hits by catalog using fragment-guided template docking. Acta Crystallogr D Struct Biol, 77, 2021
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5SAS
| Endothiapepsin in complex with compound FU290-2 | 分子名称: | (1R)-1-(4-chlorophenyl)ethyl carbamimidothioate, BROMIDE ION, DIMETHYL SULFOXIDE, ... | 著者 | Wollenhaupt, J, Metz, A, Messini, N, Barthel, T, Klebe, G, Weiss, M.S. | 登録日 | 2021-05-28 | 公開日 | 2021-09-01 | 最終更新日 | 2021-09-29 | 実験手法 | X-RAY DIFFRACTION (1.17 Å) | 主引用文献 | Frag4Lead: growing crystallographic fragment hits by catalog using fragment-guided template docking. Acta Crystallogr D Struct Biol, 77, 2021
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5SAP
| Endothiapepsin in complex with compound FU58-2 | 分子名称: | (8S)-5-(2-aminopyrimidin-4-yl)-N-[2-(dimethylamino)ethyl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamide, 1,2-ETHANEDIOL, Endothiapepsin, ... | 著者 | Wollenhaupt, J, Metz, A, Messini, N, Barthel, T, Klebe, G, Weiss, M.S. | 登録日 | 2021-05-28 | 公開日 | 2021-09-01 | 最終更新日 | 2021-09-29 | 実験手法 | X-RAY DIFFRACTION (1.04 Å) | 主引用文献 | Frag4Lead: growing crystallographic fragment hits by catalog using fragment-guided template docking. Acta Crystallogr D Struct Biol, 77, 2021
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6RCI
| Crystal structure of REXO2 | 分子名称: | Oligoribonuclease, mitochondrial | 著者 | Spahr, H, Nicholls, T.J, Larsson, N.G, Gustafsson, C.M. | 登録日 | 2019-04-11 | 公開日 | 2019-10-09 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria. Mol.Cell, 76, 2019
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6RCN
| Crystal structure of REXO2-D199A-dAdA | 分子名称: | DNA (5'-D(P*AP*A)-3'), MAGNESIUM ION, Oligoribonuclease, ... | 著者 | Spahr, H, Nicholls, T.J, Larsson, N.G, Gustafsson, C.M. | 登録日 | 2019-04-11 | 公開日 | 2019-10-09 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria. Mol.Cell, 76, 2019
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4OK5
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5BOT
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4OJQ
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5BOY
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1H4V
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6OVA
| Crystal Structure of TYK2 with novel pyrrolidinone inhibitor | 分子名称: | 6-({4-[(3S)-3-cyano-3-cyclopropyl-2-oxopyrrolidin-1-yl]pyridin-2-yl}amino)-N,N-dimethylpyridine-3-carboxamide, Non-receptor tyrosine-protein kinase TYK2 | 著者 | Skene, R.J, Hoffman, I.D. | 登録日 | 2019-05-07 | 公開日 | 2020-02-12 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Efficient synthesis of tert-butyl 3-cyano-3-cyclopropyl-2-oxopyrrolidine-4-carboxylates: Highly functionalized 2-pyrrolidinone enabling access to novel macrocyclic Tyk2 inhibitors. Bioorg.Med.Chem.Lett., 30, 2020
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8UDG
| S1V2-72 Fab bound to EHA2 from influenza B/Malaysia/2506/2004 | 分子名称: | Hemagglutinin, S1V2-72 heavy chain, S1V2-72 light chain | 著者 | Finney, J, Kong, S, Walsh Jr, R.M, Harrison, S.C, Kelsoe, G. | 登録日 | 2023-09-28 | 公開日 | 2023-11-15 | 最終更新日 | 2024-01-10 | 実験手法 | ELECTRON MICROSCOPY (4.98 Å) | 主引用文献 | Protective human antibodies against a conserved epitope in pre- and postfusion influenza hemagglutinin. Proc.Natl.Acad.Sci.USA, 121, 2024
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8X3H
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