3QS4
 
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2Q6H
 | | Crystal Structure Analysis of LeuT complexed with L-leucine, sodium, and clomipramine | | 分子名称: | 3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, LEUCINE, SODIUM ION, ... | | 著者 | Singh, S.K, Yamashita, A, Gouaux, E. | | 登録日 | 2007-06-05 | | 公開日 | 2007-08-21 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
Nature, 448, 2007
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6DW0
 | | Cryo-EM structure of the benzodiazepine-sensitive alpha1beta1gamma2S tri-heteromeric GABAA receptor in complex with GABA (Whole map) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1, ... | | 著者 | Phulera, S, Zhu, H, Yu, J, Yoshioka, C, Gouaux, E. | | 登録日 | 2018-06-26 | | 公開日 | 2018-08-08 | | 最終更新日 | 2024-11-20 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Cryo-EM structure of the benzodiazepine-sensitive alpha 1 beta 1 gamma 2S tri-heteromeric GABAAreceptor in complex with GABA.
Elife, 7, 2018
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3RHW
 | | C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab and ivermectin | | 分子名称: | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, Avermectin-sensitive glutamate-gated chloride channel GluCl alpha, ... | | 著者 | Hibbs, R.E, Gouaux, E. | | 登録日 | 2011-04-12 | | 公開日 | 2011-05-25 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (3.26 Å) | | 主引用文献 | Principles of activation and permeation in an anion-selective Cys-loop receptor.
Nature, 474, 2011
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1MM6
 | | crystal structure of the GluR2 ligand binding core (S1S2J) in complex with quisqualate in a non zinc crystal form at 2.15 angstroms resolution | | 分子名称: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, GLUTAMATE RECEPTOR 2, GLYCEROL, ... | | 著者 | Jin, R, Horning, M, Mayer, M.L, Gouaux, E. | | 登録日 | 2002-09-03 | | 公開日 | 2003-02-04 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Mechanism of activation and selectivity in a ligand-gated ion channel: Structural and functional studies of GluR2 and quisqualate
Biochemistry, 41, 2002
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3RIF
 | | C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and glutamate. | | 分子名称: | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, Avermectin-sensitive glutamate-gated chloride channel GluCl alpha, ... | | 著者 | Hibbs, R.E, Gouaux, E. | | 登録日 | 2011-04-13 | | 公開日 | 2011-05-25 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (3.345 Å) | | 主引用文献 | Principles of activation and permeation in an anion-selective Cys-loop receptor.
Nature, 474, 2011
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2QTS
 | | Structure of an acid-sensing ion channel 1 at 1.9 A resolution and low pH | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel, CHLORIDE ION, ... | | 著者 | Jasti, J, Furukawa, H, Gonzales, E.B, Gouaux, E. | | 登録日 | 2007-08-02 | | 公開日 | 2007-09-25 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure of acid-sensing ion channel 1 at 1.9A resolution and low pH
Nature, 449, 2007
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2A65
 | | Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter transporters | | 分子名称: | CHLORIDE ION, LEUCINE, Na(+):neurotransmitter symporter (Snf family), ... | | 著者 | Yamashita, A, Singh, S.K, Kawate, T, Jin, Y, Gouaux, E. | | 登録日 | 2005-07-01 | | 公開日 | 2005-08-02 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Crystal structure of a bacterial homologue of Na(+)/Cl(-)-dependent neurotransmitter transporters.
Nature, 437, 2005
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3RIA
 | | C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and iodide. | | 分子名称: | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, Avermectin-sensitive glutamate-gated chloride channel GluCl alpha, CHLORIDE ION, ... | | 著者 | Hibbs, R.E, Gouaux, E. | | 登録日 | 2011-04-13 | | 公開日 | 2011-05-25 | | 最終更新日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Principles of activation and permeation in an anion-selective Cys-loop receptor.
Nature, 474, 2011
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3RI5
 | | C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and picrotoxin | | 分子名称: | (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Hibbs, R.E, Gouaux, E. | | 登録日 | 2011-04-12 | | 公開日 | 2011-05-25 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Principles of activation and permeation in an anion-selective Cys-loop receptor.
Nature, 474, 2011
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2A5S
 | | Crystal Structure Of The NR2A Ligand Binding Core In Complex With Glutamate | | 分子名称: | GLUTAMIC ACID, N-methyl-D-aspartate receptor NMDAR2A subunit | | 著者 | Furukawa, H, Singh, S.K, Mancusso, R, Gouaux, E. | | 登録日 | 2005-06-30 | | 公開日 | 2005-11-15 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Subunit arrangement and function in NMDA receptors
Nature, 438, 2005
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2A5T
 | | Crystal Structure Of The NR1/NR2A ligand-binding cores complex | | 分子名称: | GLUTAMIC ACID, GLYCINE, N-methyl-D-aspartate receptor NMDAR1-4a subunit, ... | | 著者 | Furukawa, H, Singh, S.K, Mancusso, R, Gouaux, E. | | 登録日 | 2005-06-30 | | 公開日 | 2005-11-15 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Subunit arrangement and function in NMDA receptors
Nature, 438, 2005
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7LH3
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7LH2
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7LGU
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7LGW
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4XP4
 | | X-ray structure of Drosophila dopamine transporter in complex with cocaine | | 分子名称: | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, ANTIBODY FRAGMENT HEAVY CHAIN-PROTEIN, 9D5-HEAVY CHAIN, ... | | 著者 | Aravind, P, Wang, K, Gouaux, E. | | 登録日 | 2015-01-16 | | 公開日 | 2015-05-06 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter.
Nature, 521, 2015
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4XNU
 | | X-ray structure of Drosophila dopamine transporter in complex with nisoxetine | | 分子名称: | CHLORIDE ION, CHOLESTEROL, Integral membrane protein-dopamine transporter, ... | | 著者 | Aravind, P, Wang, K, Gouaux, E. | | 登録日 | 2015-01-16 | | 公開日 | 2015-05-13 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | | 主引用文献 | X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine.
Nat.Struct.Mol.Biol., 22, 2015
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4XPF
 | | X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to RTI-55 | | 分子名称: | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, ANTIBODY FRAGMENT HEAVY CHAIN-PROTEIN, 9D5-HEAVY CHAIN, ... | | 著者 | Penmatsa, A, Wang, K.H, Gouaux, E. | | 登録日 | 2015-01-16 | | 公開日 | 2015-05-06 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (3.273 Å) | | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter.
Nature, 521, 2015
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4XPG
 | | X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to beta-CFT or Win35428 | | 分子名称: | CHLORIDE ION, CHOLESTEROL, Dopamine transporter, ... | | 著者 | Penmatsa, A, Wang, K.H, Gouaux, E. | | 登録日 | 2015-01-16 | | 公開日 | 2015-05-06 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3.21 Å) | | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter.
Nature, 521, 2015
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4XPB
 | | X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to cocaine | | 分子名称: | Antibody fragment heavy chain-protein, 9D5-heavy chain, Antibody fragment light chain-protein, ... | | 著者 | Aravind, P, Wang, K, Gouaux, E. | | 登録日 | 2015-01-16 | | 公開日 | 2015-05-13 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter.
Nature, 521, 2015
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4XPT
 | | X-ray structure of Drosophila dopamine transporter with subsiteB mutations D121G/S426M and EL2 deletion of 162-201 in complex with substrate analogue 3,4 dichlorophen ethylamine | | 分子名称: | 2-(3,4-dichlorophenyl)ethanamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | 著者 | Aravind, P, Wang, K, Gouaux, E. | | 登録日 | 2015-01-17 | | 公開日 | 2015-05-06 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (3.36 Å) | | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter.
Nature, 521, 2015
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4XNX
 | | X-ray structure of Drosophila dopamine transporter in complex with reboxetine | | 分子名称: | (2R)-2-[(R)-(2-ethoxyphenoxy)(phenyl)methyl]morpholine, Antibody fragment heavy chain, CHLORIDE ION, ... | | 著者 | Aravind, P, Wang, K, Gouaux, E. | | 登録日 | 2015-01-16 | | 公開日 | 2015-05-13 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine.
Nat.Struct.Mol.Biol., 22, 2015
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4XP6
 | | X-ray structure of Drosophila dopamine transporter bound to psychostimulant methamphetamine | | 分子名称: | (2S)-N-methyl-1-phenylpropan-2-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody fragment heavy chain-protein, ... | | 著者 | Aravind, P, Wang, K, Gouaux, E. | | 登録日 | 2015-01-16 | | 公開日 | 2015-05-13 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter.
Nature, 521, 2015
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4XPH
 | | X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to 3,4dichlorophenethylamine | | 分子名称: | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, 2-(3,4-dichlorophenyl)ethanamine, Antibody fragment heavy chain, ... | | 著者 | Penmatsa, A, Wang, K, Gouaux, E. | | 登録日 | 2015-01-17 | | 公開日 | 2015-05-06 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter.
Nature, 521, 2015
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