5HQA
| A Glycoside Hydrolase Family 97 enzyme in complex with Acarbose from Pseudoalteromonas sp. strain K8 | 分子名称: | 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, Alpha-glucosidase, CALCIUM ION, ... | 著者 | Li, J, He, C, Xiao, Y. | 登録日 | 2016-01-21 | 公開日 | 2017-01-11 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.747 Å) | 主引用文献 | Structures of PspAG97A alpha-glucoside hydrolase reveal a novel mechanism for chloride induced activation. J. Struct. Biol., 196, 2016
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5OSG
| Structure of KSRP in context of Leishmania donovani 80S | 分子名称: | 18S rRNA, 40S ribosomal protein S6, RNA binding protein, ... | 著者 | Brito Querido, J, Mancera-Martinez, E, Vicens, Q, Bochler, A, Chicher, J, Simonetti, A, Hashem, Y. | 登録日 | 2017-08-17 | 公開日 | 2017-11-15 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | The cryo-EM Structure of a Novel 40S Kinetoplastid-Specific Ribosomal Protein. Structure, 25, 2017
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5HQB
| A Glycoside Hydrolase Family 97 enzyme (E480Q) in complex with Panose from Pseudoalteromonas sp. strain K8 | 分子名称: | Alpha-glucosidase, CALCIUM ION, CHLORIDE ION, ... | 著者 | Li, J, He, C, Xiao, Y. | 登録日 | 2016-01-21 | 公開日 | 2017-01-11 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structures of PspAG97A alpha-glucoside hydrolase reveal a novel mechanism for chloride induced activation. J. Struct. Biol., 196, 2016
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7V27
| RBD/XG005 local refinement | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, XG005-VH, ... | 著者 | Zhan, W.Q, Zhang, X, Sun, L, Chen, Z.G. | 登録日 | 2021-08-07 | 公開日 | 2022-08-10 | 実験手法 | ELECTRON MICROSCOPY (4.18 Å) | 主引用文献 | RBD/XG005 local refinement To Be Published
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7V6G
| Structure of Candida albicans Fructose-1,6-bisphosphate aldolase mutation C157S with CN39 | 分子名称: | 1,2-ETHANEDIOL, Fructose-bisphosphate aldolase, ZINC ION, ... | 著者 | Cao, H, Huang, Y, Chen, H, Wan, C, Ren, Y, Wan, J. | 登録日 | 2021-08-20 | 公開日 | 2022-02-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.343 Å) | 主引用文献 | Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis. J.Med.Chem., 65, 2022
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5B6K
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7DSC
| CALHM1 open state with disordered CTH | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Calcium homeostasis modulator 1 | 著者 | Ren, Y, Yang, X, Shen, Y.Q. | 登録日 | 2020-12-30 | 公開日 | 2022-01-05 | 最終更新日 | 2023-01-25 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Cryo-EM structure of the heptameric calcium homeostasis modulator 1 channel. J.Biol.Chem., 298, 2022
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7DSD
| CALHM1 close state with disordered CTH | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Calcium homeostasis modulator 1 | 著者 | Ren, Y, Yang, X, Shen, Y.Q. | 登録日 | 2020-12-30 | 公開日 | 2022-01-05 | 最終更新日 | 2023-01-25 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Cryo-EM structure of the heptameric calcium homeostasis modulator 1 channel. J.Biol.Chem., 298, 2022
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7DSE
| CALHM1 close state with ordered CTH | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Calcium homeostasis modulator 1 | 著者 | Ren, Y, Yang, X, Shen, Y.Q. | 登録日 | 2020-12-30 | 公開日 | 2022-01-05 | 最終更新日 | 2023-01-25 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM structure of the heptameric calcium homeostasis modulator 1 channel. J.Biol.Chem., 298, 2022
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7Y3V
| Crystal structure of CdpNPT in complex with harmane | 分子名称: | 1-methyl-9H-pyrido[3,4-b]indole, Cyclic dipeptide N-prenyltransferase, PHOSPHATE ION | 著者 | Nakashima, Y, Morita, H. | 登録日 | 2022-06-13 | 公開日 | 2023-04-05 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Catalytic potential of a fungal indole prenyltransferase toward beta-carbolines, harmine and harman, and their prenylation effects on antibacterial activity. J.Biosci.Bioeng., 134, 2022
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7XVJ
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7DTU
| Human Calcium-Sensing Receptor bound with L-Trp | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Extracellular calcium-sensing receptor, ... | 著者 | Ling, S.L, Tian, C.L, Shi, P, Liu, S.L, Meng, X.Y, Liu, L, Sun, D.M, Shi, C.W. | 登録日 | 2021-01-06 | 公開日 | 2021-03-10 | 最終更新日 | 2021-04-14 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca 2+ ions and L-tryptophan. Cell Res., 31, 2021
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7DTW
| Human Calcium-Sensing Receptor in the inactive close-close conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Extracellular calcium-sensing receptor | 著者 | Ling, S.L, Tian, C.L, Shi, P, Liu, S.L, Meng, X.Y, Liu, L, Sun, D.M, Shi, C.W. | 登録日 | 2021-01-06 | 公開日 | 2021-03-10 | 最終更新日 | 2021-04-14 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca 2+ ions and L-tryptophan. Cell Res., 31, 2021
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7DTT
| Human Calcium-Sensing Receptor bound with calcium ions | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Ling, S.L, Tian, C.L, Shi, P, Liu, S.L, Meng, X.Y, Sun, D.M, Liu, L, Shi, C.W. | 登録日 | 2021-01-06 | 公開日 | 2021-03-10 | 最終更新日 | 2021-04-14 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca 2+ ions and L-tryptophan. Cell Res., 31, 2021
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7DTV
| Human Calcium-Sensing Receptor bound with L-Trp and calcium ions | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Ling, S.L, Tian, C.L, Shi, P, Liu, S.L, Meng, X.Y, Liu, L, Sun, D.M, Shi, C.W. | 登録日 | 2021-01-06 | 公開日 | 2021-03-10 | 最終更新日 | 2021-04-14 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca 2+ ions and L-tryptophan. Cell Res., 31, 2021
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6VC8
| Crystal structure of wild-type KRAS4b(1-169) in complex with GMPPNP and Mg ion | 分子名称: | GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 著者 | Tran, T.H, Davies, D.R, Edwards, T.E, Simanshu, D.K. | 登録日 | 2019-12-20 | 公開日 | 2021-02-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Machine learning-driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins. Proc.Natl.Acad.Sci.USA, 119, 2022
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6BH3
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6BGW
| LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR 2-((2-chlorophenyl)(2-(4,4-difluoropiperidin-1-yl)ethoxy)methyl)-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acid(Compound N41) | 分子名称: | 2-{(S)-(2-chlorophenyl)[2-(4,4-difluoropiperidin-1-yl)ethoxy]methyl}-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acid, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Horton, J.R, Cheng, X. | 登録日 | 2017-10-29 | 公開日 | 2018-03-28 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.644 Å) | 主引用文献 | Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A. J. Med. Chem., 61, 2018
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6BH4
| LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR 5-(1-(tert-butyl)-1H-pyrazol-4-yl)-6-isopropyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile (Compound N75/CPI-48) | 分子名称: | 1,2-ETHANEDIOL, 5-(1-tert-butyl-1H-pyrazol-4-yl)-7-oxo-6-(propan-2-yl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile, GLYCEROL, ... | 著者 | Horton, J.R, Cheng, X. | 登録日 | 2017-10-29 | 公開日 | 2018-03-28 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.047 Å) | 主引用文献 | Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A. J. Med. Chem., 61, 2018
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8C4A
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8E2B
| N-terminal domain of S. aureus GpsB | 分子名称: | Cell cycle protein GpsB, GLYCEROL | 著者 | Sacco, M, Chen, Y. | 登録日 | 2022-08-14 | 公開日 | 2023-08-09 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Staphylococcus aureus FtsZ and PBP4 bind to the conformationally dynamic N-terminal domain of GpsB. Elife, 13, 2024
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8E2C
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7YVC
| Aplysia californica FaNaC in apo state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Chen, Q.F, Liu, F.L, Dang, Y, Feng, H, Zhang, Z, Ye, S. | 登録日 | 2022-08-19 | 公開日 | 2023-08-09 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily. Nat.Chem.Biol., 19, 2023
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7YVB
| Aplysia californica FaNaC in ligand bound state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FMRFamide-gated Na+ channel, ... | 著者 | Chen, Q.F, Liu, F.L, Dang, Y, Feng, H, Zhang, Z, Ye, S. | 登録日 | 2022-08-19 | 公開日 | 2023-08-09 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily. Nat.Chem.Biol., 19, 2023
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6G2X
| Crystal structure of the p97 D2 domain in a helical split-washer conformation | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-DIPHOSPHATE, DIMETHYL SULFOXIDE, ... | 著者 | Stach, L, Morgan, R.M.L, Freemont, P.S. | 登録日 | 2018-03-23 | 公開日 | 2019-04-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.078 Å) | 主引用文献 | Crystal structure of the catalytic D2 domain of the AAA+ ATPase p97 reveals a putative helical split-washer-type mechanism for substrate unfolding. Febs Lett., 594, 2020
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