8HS2
| Orphan GPR20 in complex with Fab046 | 分子名称: | Light chain of Fab046, Soluble cytochrome b562,G-protein coupled receptor 20, heavy chain of Fab046 | 著者 | Lin, X, Jiang, S, Xu, F. | 登録日 | 2022-12-16 | 公開日 | 2023-03-08 | 最終更新日 | 2023-03-15 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | The activation mechanism and antibody binding mode for orphan GPR20. Cell Discov, 9, 2023
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8HS3
| Gi bound orphan GPR20 in ligand-free state | 分子名称: | Ggama, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Lin, X, Jiang, S, Xu, F. | 登録日 | 2022-12-16 | 公開日 | 2023-03-08 | 最終更新日 | 2023-03-15 | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | 主引用文献 | The activation mechanism and antibody binding mode for orphan GPR20. Cell Discov, 9, 2023
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8HSC
| Gi bound Orphan GPR20 complex with Fab046 in ligand-free state | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Lin, X, Jiang, S, Xu, F. | 登録日 | 2022-12-19 | 公開日 | 2023-03-08 | 最終更新日 | 2023-03-15 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | The activation mechanism and antibody binding mode for orphan GPR20. Cell Discov, 9, 2023
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5XNM
| Structure of unstacked C2S2M2-type PSII-LHCII supercomplex from Pisum sativum | 分子名称: | (1R,3R)-6-{(3E,5E,7E,9E,11E,13E,15E,17E)-18-[(1S,4R,6R)-4-HYDROXY-2,2,6-TRIMETHYL-7-OXABICYCLO[4.1.0]HEPT-1-YL]-3,7,12,16-TETRAMETHYLOCTADECA-1,3,5,7,9,11,13,15,17-NONAENYLIDENE}-1,5,5-TRIMETHYLCYCLOHEXANE-1,3-DIOL, (3R,3'R,6S)-4,5-DIDEHYDRO-5,6-DIHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, (3S,5R,6S,3'S,5'R,6'S)-5,6,5',6'-DIEPOXY-5,6,5',6'- TETRAHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, ... | 著者 | Su, X.D, Ma, J, Wei, X.P, Cao, P, Zhu, D.J, Chang, W.R, Liu, Z.F, Zhang, X.Z, Li, M. | 登録日 | 2017-05-23 | 公開日 | 2017-09-20 | 最終更新日 | 2019-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure and assembly mechanism of plant C2S2M2-type PSII-LHCII supercomplex Science, 357, 2017
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5XNL
| Structure of stacked C2S2M2-type PSII-LHCII supercomplex from Pisum sativum | 分子名称: | (1R,3R)-6-{(3E,5E,7E,9E,11E,13E,15E,17E)-18-[(1S,4R,6R)-4-HYDROXY-2,2,6-TRIMETHYL-7-OXABICYCLO[4.1.0]HEPT-1-YL]-3,7,12,16-TETRAMETHYLOCTADECA-1,3,5,7,9,11,13,15,17-NONAENYLIDENE}-1,5,5-TRIMETHYLCYCLOHEXANE-1,3-DIOL, (3R,3'R,6S)-4,5-DIDEHYDRO-5,6-DIHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, (3S,5R,6S,3'S,5'R,6'S)-5,6,5',6'-DIEPOXY-5,6,5',6'- TETRAHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, ... | 著者 | Su, X.D, Ma, J, Wei, X.P, Cao, P, Zhu, D.J, Chang, W.R, Liu, Z.F, Zhang, X.Z, Li, M. | 登録日 | 2017-05-23 | 公開日 | 2017-09-20 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structure and assembly mechanism of plant C2S2M2-type PSII-LHCII supercomplex Science, 357, 2017
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5XNN
| Structure of M-LHCII and CP24 complexes in the stacked C2S2M2-type PSII-LHCII supercomplex from Pisum sativum | 分子名称: | (1R,3R)-6-{(3E,5E,7E,9E,11E,13E,15E,17E)-18-[(1S,4R,6R)-4-HYDROXY-2,2,6-TRIMETHYL-7-OXABICYCLO[4.1.0]HEPT-1-YL]-3,7,12,16-TETRAMETHYLOCTADECA-1,3,5,7,9,11,13,15,17-NONAENYLIDENE}-1,5,5-TRIMETHYLCYCLOHEXANE-1,3-DIOL, (3R,3'R,6S)-4,5-DIDEHYDRO-5,6-DIHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, (3S,5R,6S,3'S,5'R,6'S)-5,6,5',6'-DIEPOXY-5,6,5',6'- TETRAHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, ... | 著者 | Su, X.D, Ma, J, Wei, X.P, Cao, P, Zhu, D.J, Chang, W.R, Liu, Z.F, Zhang, X.Z, Li, M. | 登録日 | 2017-05-23 | 公開日 | 2017-09-20 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure and assembly mechanism of plant C2S2M2-type PSII-LHCII supercomplex Science, 357, 2017
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7L1K
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6J1O
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6J46
| LepI-SAH complex structure | 分子名称: | O-methyltransferase lepI, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Qiu, S, Wei, C. | 登録日 | 2019-01-08 | 公開日 | 2019-05-01 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.621 Å) | 主引用文献 | Deciphering the regulatory and catalytic mechanisms of an unusual SAM-dependent enzyme. Signal Transduct Target Ther, 4, 2019
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3SVW
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6J24
| Crystal structure of a SAM-dependent methyltransferase LepI in complex with its substrate | 分子名称: | (3~{S},4'~{R},4'~{a}~{S},6'~{R},8'~{a}~{S})-4',6'-dimethyl-5-phenyl-spiro[1~{H}-pyridine-3,5'-2,3,4,4~{a},6,8~{a}-hexahydro-1~{H}-naphthalene]-2,4-dione, O-methyltransferase, S-ADENOSYLMETHIONINE | 著者 | Qiu, S, Wei, C. | 登録日 | 2018-12-30 | 公開日 | 2019-05-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.244 Å) | 主引用文献 | Deciphering the regulatory and catalytic mechanisms of an unusual SAM-dependent enzyme. Signal Transduct Target Ther, 4, 2019
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3SJL
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3SLE
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6LUO
| Structure of nurse shark beta-2-microglobulin | 分子名称: | Beta-2-microglobulin | 著者 | Xia, C, Wu, Y. | 登録日 | 2020-01-30 | 公開日 | 2021-04-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.302 Å) | 主引用文献 | The Structure of a Peptide-Loaded Shark MHC Class I Molecule Reveals Features of the Binding between beta 2 -Microglobulin and H Chain Conserved in Evolution. J Immunol., 2021
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6LUP
| Crystal structure of shark MHC CLASS I for 2.3 angstrom | 分子名称: | Beta-2-microglobulin, MHC class I protein, PHE-ALA-ASN-PHE-PHE-ILE-ARG-GLY-LEU | 著者 | Wu, Y, Xia, C. | 登録日 | 2020-01-30 | 公開日 | 2021-04-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.302 Å) | 主引用文献 | The Structure of a Peptide-Loaded Shark MHC Class I Molecule Reveals Features of the Binding between beta 2 -Microglobulin and H Chain Conserved in Evolution. J Immunol., 2021
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5YLX
| Integrated illustration of a valid epitope based on the SLA class I structure and tetramer technique could carry forward the development of molecular vaccine in swine species | 分子名称: | Beta-2-microglobulin, MHC class I antigen, PRRSV-NSP9-TMP9 peptide | 著者 | Pan, X.C, Wei, X.H, Zhang, N, Xia, C. | 登録日 | 2017-10-20 | 公開日 | 2018-10-24 | 最終更新日 | 2020-05-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Illumination of PRRSV Cytotoxic T Lymphocyte Epitopes by the Three-Dimensional Structure and Peptidome of Swine Lymphocyte Antigen Class I (SLA-I). Front Immunol, 10, 2019
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6O07
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8TBF
| Tricomplex of RMC-7977, KRAS WT, and CypA | 分子名称: | (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide, 1,2-ETHANEDIOL, GTPase KRas, ... | 著者 | Tomlinson, A.C.A, Chen, A, Knox, J.E, Yano, J.K. | 登録日 | 2023-06-28 | 公開日 | 2024-02-07 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature, 629, 2024
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8GO7
| Fungal immunomodulatory protein FIP-nha N5+39A | 分子名称: | Fungal immunomodulatory protein FIP-nha | 著者 | Liu, Y, Bastiaan-Net, S, Hoppenbrouwers, T, Li, Z, Wichers, H.J. | 登録日 | 2022-08-24 | 公開日 | 2023-08-30 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.303 Å) | 主引用文献 | Glycosylation Contributes to Thermostability and Proteolytic Resistance of rFIP-nha ( Nectria haematococca ). Molecules, 28, 2023
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8GO6
| Fungal immunomodulatory protein FIP-nha N39A | 分子名称: | fungal immunomodulatory protein FIP-nha N39A | 著者 | Liu, Y, Bastiaan-Net, S, Hoppenbrouwers, T, Li, Z, Wichers, H.J. | 登録日 | 2022-08-24 | 公開日 | 2023-08-30 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.813 Å) | 主引用文献 | Glycosylation Contributes to Thermostability and Proteolytic Resistance of rFIP-nha ( Nectria haematococca ). Molecules, 28, 2023
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8GO5
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8W6P
| Crystal structure of dimeric murine SMPDL3A | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acid sphingomyelinase-like phosphodiesterase 3a, ... | 著者 | Zhang, C, Liu, P, Fan, S, Hou, Y. | 登録日 | 2023-08-29 | 公開日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing. Immunity, 56, 2023
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8W6R
| murine SMPDL3A bound to sulfate | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acid sphingomyelinase-like phosphodiesterase 3a, ... | 著者 | Zhang, C, Liu, P, Fan, S. | 登録日 | 2023-08-29 | 公開日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing. Immunity, 56, 2023
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7DEA
| Structure of an avian influenza H5 hemagglutinin from the influenza virus A/duck Northern China/22/2017 (H5N6) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin | 著者 | Sun, H, Sun, H, Song, J, Zhang, W, Wei, X, Qi, J, Gao, G.F, Liu, J. | 登録日 | 2020-11-03 | 公開日 | 2021-11-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | Haemagglutinin and neuraminidase acid stability in H5N6 avian influenza virus confers infection adaptation in mammals To Be Published
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9AX6
| Tricomplex of RMC-6236, KRAS G12D, and CypA | 分子名称: | (1R,2S)-N-[(1P,7S,9S,13R,20M)-21-ethyl-20-{2-[(1R)-1-methoxyethyl]-5-(4-methylpiperazin-1-yl)pyridin-3-yl}-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-2-methylcyclopropane-1-carboxamide, GTPase KRas, MAGNESIUM ION, ... | 著者 | Tomlinson, A.C.A, Saldajeno-Concar, M, Knox, J.E, Yano, J.K. | 登録日 | 2024-03-05 | 公開日 | 2024-04-17 | 最終更新日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers. Cancer Discov, 14, 2024
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