6J24

Crystal structure of a SAM-dependent methyltransferase LepI in complex with its substrate

Summary for 6J24

• Entry DOI: 10.2210/pdb6j24/pdb
• Descriptor: O-methyltransferase, (3~{S},4'~{R},4'~{a}~{S},6'~{R},8'~{a}~{S})-4',6'-dimethyl-5-phenyl-spiro[1~{H}-pyridine-3,5'-2,3,4,4~{a},6,8~{a}-hexahydro-1~{H}-naphthalene]-2,4-dione, S-ADENOSYLMETHIONINE, ... (4 entities in total)
• Functional Keywords: complex, transferase
• Biological source: Aspergillus flavus
• Total number of polymer chains: 2
• Total formula weight: 88196.74

Authors

Qiu, S.,Wei, C. (deposition date: 2018-12-30, release date: 2019-05-01, Last modification date: 2023-11-22)

• Primary citation: Sun, Q.,Hu, Y.,Gu, Y.,Huang, J.,He, J.,Luo, L.,Yang, Y.,Yin, S.,Dou, C.,Wang, T.,Fu, X.,He, L.,Qi, S.,Zhu, X.,Yang, S.,Wei, X.,Cheng, W.; Deciphering the regulatory and catalytic mechanisms of an unusual SAM-dependent enzyme.; Signal Transduct Target Ther, 4:17-17, 2019; PubMed: 31149354; DOI: 10.1038/s41392-019-0052-y

Experimental method

X-RAY DIFFRACTION (2.244 Å)