7MKZ
| PTP1B F225Y mutant, open state | 分子名称: | CHLORIDE ION, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1 | 著者 | Torgeson, K.R, Page, R, Peti, W. | 登録日 | 2021-04-27 | 公開日 | 2022-05-18 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Conserved conformational dynamics determine enzyme activity. Sci Adv, 8, 2022
|
|
7MOV
| PTP1B 1-301 F225Y-R199N mutations | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ... | 著者 | Torgeson, K.R, Page, R, Peti, W. | 登録日 | 2021-05-03 | 公開日 | 2022-05-18 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Conserved conformational dynamics determine enzyme activity. Sci Adv, 8, 2022
|
|
5JPF
| Serine/Threonine phosphatase Z1 (Candida albicans) binds to inhibitor microcystin-LR | 分子名称: | MALONATE ION, MANGANESE (II) ION, Microcystin-LR, ... | 著者 | Choy, M.S, Chen, E.H, Peti, W, Page, R. | 登録日 | 2016-05-03 | 公開日 | 2016-08-31 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.39929724 Å) | 主引用文献 | Molecular Insights into the Fungus-Specific Serine/Threonine Protein Phosphatase Z1 in Candida albicans. Mbio, 7, 2016
|
|
5KA8
| Protein Tyrosine Phosphatase 1B L192A mutant, open state | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, Tyrosine-protein phosphatase non-receptor type 1 | 著者 | Choy, M.S, Peti, W, Page, R. | 登録日 | 2016-06-01 | 公開日 | 2017-03-01 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.971 Å) | 主引用文献 | Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65, 2017
|
|
5KA1
| Protein Tyrosine Phosphatase 1B Delta helix 7 mutant in complex with TCS401, closed state | 分子名称: | 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... | 著者 | Choy, M.S, Peti, W, Page, R. | 登録日 | 2016-06-01 | 公開日 | 2017-03-01 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65, 2017
|
|
7MN7
| PTP1B F225Y in complex with TCS401 | 分子名称: | 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... | 著者 | Torgeson, K.R, Page, R, Peti, W. | 登録日 | 2021-04-30 | 公開日 | 2022-05-18 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Conserved conformational dynamics determine enzyme activity. Sci Adv, 8, 2022
|
|
7MN9
| PTP1B 1-284 F225Y-R199N | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ... | 著者 | Torgeson, K.R, Page, R, Peti, W. | 登録日 | 2021-04-30 | 公開日 | 2022-05-18 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | 主引用文献 | Conserved conformational dynamics determine enzyme activity. Sci Adv, 8, 2022
|
|
7MNA
| PTP1B 1-284 F225Y-R199N in complex with TCS401 | 分子名称: | 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... | 著者 | Torgeson, K.R, Page, R, Peti, W. | 登録日 | 2021-04-30 | 公開日 | 2022-05-18 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Conserved conformational dynamics determine enzyme activity. Sci Adv, 8, 2022
|
|
7MNC
| PTP1B L204A | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, Tyrosine-protein phosphatase non-receptor type 1 | 著者 | Torgeson, K.R, Page, R, Peti, W. | 登録日 | 2021-04-30 | 公開日 | 2022-05-18 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Conserved conformational dynamics determine enzyme activity. Sci Adv, 8, 2022
|
|
7MND
| PTP1B L204A in complex with TCS401 | 分子名称: | 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... | 著者 | Torgeson, K.R, Page, R, Peti, W. | 登録日 | 2021-04-30 | 公開日 | 2022-05-18 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Conserved conformational dynamics determine enzyme activity. Sci Adv, 8, 2022
|
|
7MNF
| PTP1B P206G in complex with TCS401 | 分子名称: | 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... | 著者 | Torgeson, K.R, Page, R, Peti, W. | 登録日 | 2021-04-30 | 公開日 | 2022-05-18 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Conserved conformational dynamics determine enzyme activity. Sci Adv, 8, 2022
|
|
7MNE
| PTP1B P206G mutation, open state | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ... | 著者 | Torgeson, K.R, Page, R, Peti, W. | 登録日 | 2021-04-30 | 公開日 | 2022-05-18 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Conserved conformational dynamics determine enzyme activity. Sci Adv, 8, 2022
|
|
6ZQS
| Crystal structure of double-phosphorylated p38alpha with ATF2(83-102) | 分子名称: | 2-[(2,4-difluorophenyl)amino]-7-{[(2R)-2,3-dihydroxypropyl]oxy}-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one, Cyclic AMP-dependent transcription factor ATF-2, Mitogen-activated protein kinase 14 | 著者 | Kirsch, K, Sok, P, Poti, A.L, Remenyi, A. | 登録日 | 2020-07-10 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38. Nat Commun, 11, 2020
|
|
6ZR5
| Crystal structure of JNK1 in complex with ATF2(19-58) | 分子名称: | Cyclic AMP-dependent transcription factor ATF-2, MAGNESIUM ION, Mitogen-activated protein kinase 8, ... | 著者 | Kirsch, K, Zeke, A, Remenyi, A. | 登録日 | 2020-07-10 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.699 Å) | 主引用文献 | Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38. Nat Commun, 11, 2020
|
|
6GHM
| Structure of PP1 alpha phosphatase bound to ASPP2 | 分子名称: | 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Apoptosis-stimulating of p53 protein 2, ... | 著者 | Mouilleron, S, Bertran, T.M, Tapon, N, Zhou, Y. | 登録日 | 2018-05-08 | 公開日 | 2019-02-27 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail. Nat Commun, 10, 2019
|
|
6TCA
| Phosphorylated p38 and MAPKAPK2 complex with inhibitor | 分子名称: | MAP kinase-activated protein kinase 2, Mitogen-activated protein kinase 14, N-[5-(dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide | 著者 | Sok, P, Remenyi, A. | 登録日 | 2019-11-05 | 公開日 | 2020-07-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | MAP Kinase-Mediated Activation of RSK1 and MK2 Substrate Kinases. Structure, 28, 2020
|
|
2QDM
| |
2QDC
| |
2QDP
| |
2HVL
| |
7F5N
| Crystal structure of TCPTP catalytic domain | 分子名称: | Tyrosine-protein phosphatase non-receptor type 2 | 著者 | Singh, J.P, Lin, M.-J, Hsu, S.-F, Lee, C.-C, Meng, T.-C. | 登録日 | 2021-06-22 | 公開日 | 2021-12-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Crystal Structure of TCPTP Unravels an Allosteric Regulatory Role of Helix alpha 7 in Phosphatase Activity. Biochemistry, 60, 2021
|
|
7F5O
| Crystal structure of PTPN2 catalytic domain | 分子名称: | IODIDE ION, Tyrosine-protein phosphatase non-receptor type 2 | 著者 | Singh, J.P, Lin, M.-J, Hsu, S.-F, Lee, C.-C, Meng, T.-C. | 登録日 | 2021-06-22 | 公開日 | 2021-12-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal Structure of TCPTP Unravels an Allosteric Regulatory Role of Helix alpha 7 in Phosphatase Activity. Biochemistry, 60, 2021
|
|
3D42
| Crystal structure of HePTP in complex with a monophosphorylated Erk2 peptide | 分子名称: | D(-)-TARTARIC ACID, GLYCEROL, Mitogen-activated protein kinase 1 peptide, ... | 著者 | Critton, D.A, Tortajada, A, Page, R. | 登録日 | 2008-05-13 | 公開日 | 2009-03-17 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | Structural basis of substrate recognition by hematopoietic tyrosine phosphatase. Biochemistry, 47, 2008
|
|
3D44
| Crystal structure of HePTP in complex with a dually phosphorylated Erk2 peptide mimetic | 分子名称: | CHLORIDE ION, GLYCEROL, Mitogen-activated protein kinase 1 peptide, ... | 著者 | Critton, D.A, Tortajada, A, Page, R. | 登録日 | 2008-05-13 | 公開日 | 2009-03-17 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis of substrate recognition by hematopoietic tyrosine phosphatase. Biochemistry, 47, 2008
|
|