6Q50
 
 | | Structure of MPT-4, a mannose phosphorylase from Leishmania mexicana, in complex with phosphate ion | | 分子名称: | 1,2-ETHANEDIOL, MPT-4, PHOSPHATE ION, ... | | 著者 | Sobala, L.F, Males, A, Bastidas, L.M, Ward, T, Sernee, M.F, Ralton, J.E, Nero, T.L, Cobbold, S, Kloehn, J, Viera-Lara, M, Stanton, L, Hanssen, E, Parker, M.W, Williams, S.J, McConville, M.J, Davies, G.J. | | 登録日 | 2018-12-06 | | 公開日 | 2019-09-25 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites.
Cell Host Microbe, 26, 2019
|
|
6OIQ
 | | Crystal structure of MYST acetyltransferase domain in complex with inhibitor 63 | | 分子名称: | 2-fluoro-N'-(phenylsulfonyl)[1,1'-biphenyl]-3-carbohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... | | 著者 | Hermans, S.J, Chung, M.C, Parker, M.W, Thomas, T, Baell, J.B. | | 登録日 | 2019-04-09 | | 公開日 | 2019-07-03 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A.
J.Med.Chem., 62, 2019
|
|
3FFD
 | | Structure of parathyroid hormone-related protein complexed to a neutralizing monoclonal antibody | | 分子名称: | Monoclonal antibody, heavy chain, Fab fragment, ... | | 著者 | Mckinstry, W.J, Polekhina, G, Diefenbach-Jagger, H, Ho, P.W.M, Sato, K, Onuma, E, Gillespie, M.T, Martin, T.J, Parker, M.W. | | 登録日 | 2008-12-03 | | 公開日 | 2009-04-28 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis for antibody discrimination between two hormones that recognize the parathyroid hormone receptor
J.Biol.Chem., 284, 2009
|
|
3CWL
 | | Crystal structure of alpha-1-antitrypsin, crystal form B | | 分子名称: | Alpha-1-antitrypsin, CHLORIDE ION | | 著者 | Morton, C.J, Hansen, G, Feil, S.C, Adams, J.J, Parker, M.W. | | 登録日 | 2008-04-22 | | 公開日 | 2008-09-23 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding.
Protein Sci., 17, 2008
|
|
6OIO
 | | Crystal structure of MYST acetyltransferase domain in complex with inhibitor 60 | | 分子名称: | Histone acetyltransferase KAT8, N'-(phenylsulfonyl)[1,1'-biphenyl]-3-carbohydrazide, ZINC ION | | 著者 | Hermans, S.J, Chung, M.C, Parker, M.W, Thomas, T, Baell, J.B. | | 登録日 | 2019-04-09 | | 公開日 | 2019-07-03 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A.
J.Med.Chem., 62, 2019
|
|
6OWH
 | | Crystal structure of MYST acetyltransferase domain in complex with inhibitor 92 | | 分子名称: | DIMETHYL SULFOXIDE, GLYCEROL, Histone acetyltransferase KAT8, ... | | 著者 | Hermans, S.J, Chung, M.C, Parker, M.W, Thomas, T, Baell, J.B. | | 登録日 | 2019-05-09 | | 公開日 | 2020-04-01 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents.
J.Med.Chem., 63, 2020
|
|
3CWM
 | | Crystal structure of alpha-1-antitrypsin complexed with citrate | | 分子名称: | Alpha-1-antitrypsin, CITRIC ACID | | 著者 | Morton, C.J, Hansen, G, Feil, S.C, Adams, J.J, Parker, M.W. | | 登録日 | 2008-04-22 | | 公開日 | 2008-09-23 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | | 主引用文献 | Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding.
Protein Sci., 17, 2008
|
|
3DAQ
 | | Crystal structure of dihydrodipicolinate synthase from methicillin-resistant Staphylococcus aureus | | 分子名称: | CHLORIDE ION, Dihydrodipicolinate synthase, GLYCEROL | | 著者 | Dobson, R.C.J, Burgess, B.R, Jameson, G.B, Gerrard, J.A, Parker, M.W, Perugini, M.A. | | 登録日 | 2008-05-29 | | 公開日 | 2008-08-05 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Structure and evolution of a novel dimeric enzyme from a clinically-important bacterial pathogen.
J.Biol.Chem., 2008
|
|
17GS
 | |
4AHT
 | | Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification | | 分子名称: | 1,2-ETHANEDIOL, 1,3-benzodioxole-4-carboxylic acid, ACETIC ACID, ... | | 著者 | Wielens, J, Heady, S.J, Rhodes, D.I, Mulder, R.J, Dolezal, O, Deadman, J.J, Newman, J, Chalmers, D.K, Parker, M.W, Peat, T.S, Scanlon, M.J. | | 登録日 | 2012-02-07 | | 公開日 | 2012-12-19 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Parallel Screening of Low Molecular Weight Fragment Libraries: Do Differences in Methodology Affect Hit Identification?
J.Biomol.Screen, 18, 2013
|
|
4AHS
 | | Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification | | 分子名称: | 1,2-ETHANEDIOL, 1-BENZOFURAN-7-CARBOXYLIC ACID, ACETATE ION, ... | | 著者 | Wielens, J, Heady, S.J, Rhodes, D.I, Mulder, R.J, Dolezal, O, Deadman, J.J, Newman, J, Chalmers, D.K, Parker, M.W, Peat, T.S, Scanlon, M.J. | | 登録日 | 2012-02-07 | | 公開日 | 2012-12-19 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Parallel Screening of Low Molecular Weight Fragment Libraries: Do Differences in Methodology Affect Hit Identification?
J.Biomol.Screen, 18, 2013
|
|
4AH9
 | | Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification | | 分子名称: | 1,2-ETHANEDIOL, 1-(3-PHENYL-1,2,4-THIADIAZOL-5-YL)-1,4-DIAZEPANE, CHLORIDE ION, ... | | 著者 | Wielens, J, Heady, S.J, Rhodes, D.I, Mulder, R.J, Dolezal, O, Deadman, J.J, Newman, J, Chalmers, D.K, Parker, M.W, Peat, T.S, Scanlon, M.J. | | 登録日 | 2012-02-06 | | 公開日 | 2012-12-19 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Parallel Screening of Low Molecular Weight Fragment Libraries: Do Differences in Methodology Affect Hit Identification?
J.Biomol.Screen, 18, 2013
|
|
4AHR
 | | Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification | | 分子名称: | 3-(1,3-benzodioxol-5-yl)propanoic acid, ACETIC ACID, GLYCEROL, ... | | 著者 | Wielens, J, Heady, S.J, Rhodes, D.I, Mulder, R.J, Dolezal, O, Deadman, J.J, Newman, J, Chalmers, D.K, Parker, M.W, Peat, T.S, Scanlon, M.J. | | 登録日 | 2012-02-07 | | 公開日 | 2012-12-19 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Parallel Screening of Low Molecular Weight Fragment Libraries: Do Differences in Methodology Affect Hit Identification?
J.Biomol.Screen, 18, 2013
|
|
5UWC
 | | Cytokine-receptor complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, ... | | 著者 | Broughton, S.E, Parker, M.W. | | 登録日 | 2017-02-21 | | 公開日 | 2018-02-07 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.
Nat Commun, 9, 2018
|
|
4AHV
 | | Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification | | 分子名称: | 1,2-ETHANEDIOL, 1-[2-(1H-pyrazol-1-yl)phenyl]methanamine, ACETIC ACID, ... | | 著者 | Wielens, J, Heady, S.J, Rhodes, D.I, Mulder, R.J, Dolezal, O, Deadman, J.J, Newman, J, Chalmers, D.K, Parker, M.W, Peat, T.S, Scanlon, M.J. | | 登録日 | 2012-02-07 | | 公開日 | 2012-12-19 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Parallel Screening of Low Molecular Weight Fragment Libraries: Do Differences in Methodology Affect Hit Identification?
J.Biomol.Screen, 18, 2013
|
|
5UV8
 | | Interleukin-3 Receptor Complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Interleukin-3, ... | | 著者 | Broughton, S.E, Parker, M.W. | | 登録日 | 2017-02-19 | | 公開日 | 2018-02-07 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.
Nat Commun, 9, 2018
|
|
13GS
 | | GLUTATHIONE S-TRANSFERASE COMPLEXED WITH SULFASALAZINE | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-HYDROXY-(5-([4-(2-PYRIDINYLAMINO)SULFONYL]PHENYL)AZO)BENZOIC ACID, GLUTATHIONE, ... | | 著者 | Oakley, A.J, Lo Bello, M, Parker, M.W. | | 登録日 | 1997-11-20 | | 公開日 | 1999-01-13 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The Ligandin (Non-Substrate) Binding Site of Human Pi Class Glutathione Transferase is Located in the Electrophile Binding Site (H-Site).
J.Mol.Biol., 291, 1999
|
|
18GS
 | | GLUTATHIONE S-TRANSFERASE P1-1 COMPLEXED WITH 1-(S-GLUTATHIONYL)-2,4-DINITROBENZENE | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE S-(2,4 DINITROBENZENE), GLUTATHIONE S-TRANSFERASE | | 著者 | Oakley, A.J, Lo Bello, M, Ricci, G, Federici, G, Parker, M.W. | | 登録日 | 1997-12-07 | | 公開日 | 1999-01-13 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The ligandin (non-substrate) binding site of human Pi class glutathione transferase is located in the electrophile binding site (H-site).
J.Mol.Biol., 291, 1999
|
|
11GS
 | | Glutathione s-transferase complexed with ethacrynic acid-glutathione conjugate (form ii) | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ETHACRYNIC ACID, GLUTATHIONE, ... | | 著者 | Oakley, A.J, Lo Bello, M, Mazzetti, A.P, Federici, G, Parker, M.W. | | 登録日 | 1997-11-03 | | 公開日 | 1999-01-13 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The glutathione conjugate of ethacrynic acid can bind to human pi class glutathione transferase P1-1 in two different modes.
FEBS Lett., 419, 1997
|
|
16GS
 | | GLUTATHIONE S-TRANSFERASE P1-1 APO FORM 3 | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE S-TRANSFERASE, SULFATE ION | | 著者 | Oakley, A.J, Lo Bello, M, Ricci, G, Federici, G, Parker, M.W. | | 登録日 | 1997-11-30 | | 公開日 | 1999-01-13 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Evidence for an induced-fit mechanism operating in pi class glutathione transferases.
Biochemistry, 37, 1998
|
|
12GS
 | |
5VP3
 | | Light-sensitive photoprotein | | 分子名称: | CADMIUM ION, Mnemiopsin 1, NICKEL (II) ION, ... | | 著者 | Gorman, M.A, Parker, M.W. | | 登録日 | 2017-05-04 | | 公開日 | 2018-05-09 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.151 Å) | | 主引用文献 | Reaction mechanism of the bioluminescent protein mnemiopsin1 revealed by X-ray crystallography and QM/MM simulations.
J. Biol. Chem., 294, 2019
|
|
14GS
 | | GLUTATHIONE S-TRANSFERASE P1-1 APO FORM 1 | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE S-TRANSFERASE | | 著者 | Oakley, A.J, Lo Bello, M, Ricci, G, Federici, G, Parker, M.W. | | 登録日 | 1997-11-29 | | 公開日 | 1999-01-13 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Evidence for an induced-fit mechanism operating in pi class glutathione transferases.
Biochemistry, 37, 1998
|
|
1OWT
 | | Structure of the Alzheimer's disease amyloid precursor protein copper binding domain | | 分子名称: | Amyloid beta A4 protein | | 著者 | Barnham, K.J, McKinstry, W.J, Multhaup, G, Galatis, D, Morton, C.J, Curtain, C.C, Williamson, N.A, White, A.R, Hinds, M.G, Norton, R.S, Beyreuther, K, Masters, C.L, Parker, M.W, Cappai, R. | | 登録日 | 2003-03-30 | | 公開日 | 2003-05-13 | | 最終更新日 | 2024-10-30 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of the Alzheimer's Disease Amyloid Precursor Protein Copper Binding Domain. A REGULATOR OF NEURONAL COPPER HOMEOSTASIS.
J.Biol.Chem., 278, 2003
|
|
1PFO
 | | PERFRINGOLYSIN O | | 分子名称: | PERFRINGOLYSIN O | | 著者 | Rossjohn, J, Parker, M.W. | | 登録日 | 1997-07-31 | | 公開日 | 1998-08-05 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure of a cholesterol-binding, thiol-activated cytolysin and a model of its membrane form.
Cell(Cambridge,Mass.), 89, 1997
|
|
