Cytokine-receptor complex

Summary for 5UWC

DescriptorInterleukin-3 receptor subunit alpha, Interleukin-3, N-ACETYL-D-GLUCOSAMINE, ... (8 entities in total)
Functional Keywordscytokine, receptor, signalling, signaling protein
Biological sourceHomo sapiens (Human)
Cellular locationMembrane; Single-pass type I membrane protein P26951
Secreted P08700
Total number of polymer chains2
Total molecular weight48796.86
Broughton, S.E.,Parker, M.W. (deposition date: 2017-02-21, release date: 2018-02-07)
Primary citation
Broughton, S.E.,Hercus, T.R.,Nero, T.L.,Kan, W.L.,Barry, E.F.,Dottore, M.,Cheung Tung Shing, K.S.,Morton, C.J.,Dhagat, U.,Hardy, M.P.,Wilson, N.J.,Downton, M.T.,Schieber, C.,Hughes, T.P.,Lopez, A.F.,Parker, M.W.
A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.
Nat Commun, 9:386-386, 2018
PubMed: 29374162 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-017-02633-7
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.239100.3%2.8%10.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload