5UWC
Cytokine-receptor complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (G) | Interleukin-3 receptor subunit alpha | polymer | 288 | 33253.6 | 1 | UniProt (P26951) Pfam (PF18611) Pfam (PF09240) | Homo sapiens (Human) | IL-3RA |
| 2 | B (I) | Interleukin-3 | polymer | 122 | 13969.9 | 1 | UniProt (P08700) Pfam (PF02059) | Homo sapiens (Human) | IL-3,Hematopoietic growth factor,Mast cell growth factor,MCGF,Multipotential colony-stimulating factor,P-cell-stimulating factor |
| 3 | C (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G28454KX) | |||
| 4 | D (G) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 5 | E, H (G, I) | CITRIC ACID | non-polymer | 192.1 | 2 | Chemie (CIT) | |||
| 6 | F (G) | IMIDAZOLE | non-polymer | 69.1 | 1 | Chemie (IMD) | |||
| 7 | G (G) | {[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID | non-polymer | 292.2 | 1 | Chemie (EDT) | |||
| 8 | I, J (G, I) | water | water | 18.0 | 64 | Chemie (HOH) |
Sequence modifications
G: 20 - 307 (UniProt: P26951)
I: 12 - 133 (UniProt: P08700)
| PDB | External Database | Details |
|---|---|---|
| Gln 212 | Asn 212 | engineered mutation |
| Val 299 | Ala 299 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Tyr 13 | Trp 32 | engineered mutation |
| Trp 116 | Lys 135 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 47223.5 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 570.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 966.8 | |
| All* | Total formula weight | 48760.8 |
