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7QQX
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BU of 7qqx by Molmil
SpCas9 bound to FANCF off-target5 DNA substrate
分子名称: CRISPR-associated endonuclease Cas9/Csn1, FANCF off-target5 non-target strand, FANCF off-target5 target strand, ...
著者Pacesa, M, Jinek, M.
登録日2022-01-10
公開日2022-10-26
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for Cas9 off-target activity.
Cell, 185, 2022
7QR0
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BU of 7qr0 by Molmil
SpCas9 bound to TRAC off-target1 DNA substrate
分子名称: CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, POTASSIUM ION, ...
著者Pacesa, M, Jinek, M.
登録日2022-01-10
公開日2022-10-26
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for Cas9 off-target activity.
Cell, 185, 2022
7QQZ
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BU of 7qqz by Molmil
SpCas9 bound to FANCF off-target7 DNA substrate
分子名称: CRISPR-associated endonuclease Cas9/Csn1, FANCF off-target7 non-target strand, FANCF off-target7 target strand, ...
著者Pacesa, M, Jinek, M.
登録日2022-01-10
公開日2022-10-26
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural basis for Cas9 off-target activity.
Cell, 185, 2022
7QQW
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BU of 7qqw by Molmil
SpCas9 bound to FANCF off-target4 DNA substrate
分子名称: CRISPR-associated endonuclease Cas9/Csn1, FANCF off-target4 non-target strand, FANCF off-target4 target strand, ...
著者Pacesa, M, Jinek, M.
登録日2022-01-10
公開日2022-10-26
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural basis for Cas9 off-target activity.
Cell, 185, 2022
7QR1
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BU of 7qr1 by Molmil
SpCas9 bound to TRAC off-target2 DNA substrate
分子名称: CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, POTASSIUM ION, ...
著者Pacesa, M, Jinek, M.
登録日2022-01-10
公開日2022-10-26
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis for Cas9 off-target activity.
Cell, 185, 2022
7QR7
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BU of 7qr7 by Molmil
SpCas9 bound to AAVS1 off-target2 DNA substrate
分子名称: AAVS1 off-target2 non-target strand, AAVS1 off-target2 target strand, AAVS1 sgRNA, ...
著者Pacesa, M, JInek, M.
登録日2022-01-10
公開日2022-10-26
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural basis for Cas9 off-target activity.
Cell, 185, 2022
8S9V
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BU of 8s9v by Molmil
CRISPR-Cas type III-D effector complex bound to a self-target RNA in the pre-cleavage state
分子名称: CRISPR RNA, Cas10, Cas7-2x, ...
著者Schwartz, E.A, Taylor, D.W.
登録日2023-03-30
公開日2024-04-24
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献RNA targeting and cleavage by the type III-Dv CRISPR effector complex.
Nat Commun, 15, 2024
8S9X
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BU of 8s9x by Molmil
CRISPR-Cas type III-D effector complex bound to self-target RNA in a post-cleavage state
分子名称: CRISPR RNA, Cas10, Cas7-2x, ...
著者Schwartz, E.A, Taylor, D.W.
登録日2023-03-30
公開日2024-04-24
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.44 Å)
主引用文献RNA targeting and cleavage by the type III-Dv CRISPR effector complex.
Nat Commun, 15, 2024
8S9T
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BU of 8s9t by Molmil
CRISPR-Cas type III-D effector complex
分子名称: CRISPR RNA, Cas10, Cas7-2x, ...
著者Schwartz, E.A, Taylor, D.W.
登録日2023-03-30
公開日2024-04-24
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (2.52 Å)
主引用文献RNA targeting and cleavage by the type III-Dv CRISPR effector complex.
Nat Commun, 15, 2024
8S9U
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BU of 8s9u by Molmil
CRISPR-Cas type III-D effector complex bound to a target RNA
分子名称: CRISPR RNA, Cas10, Cas7-2x, ...
著者Schwartz, E.A, Taylor, D.W.
登録日2023-03-30
公開日2024-04-24
実験手法ELECTRON MICROSCOPY (2.77 Å)
主引用文献Type III CRISPR-Cas effectors act as protein-assisted ribozymes
To Be Published
6HUD
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BU of 6hud by Molmil
Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain (AL) amyloidosis patient.
分子名称: Monoclonal immunoglobulin light chains (LC)
著者Paissoni, C, Camilloni, C.
登録日2018-10-06
公開日2019-03-27
最終更新日2019-04-03
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain AL amyloidosis patient.
Nat Commun, 10, 2019
4R97
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BU of 4r97 by Molmil
Crystal structure of the Fab fragment of KKO
分子名称: GLYCEROL, ZINC ION, platelet factor 4 antibody KKO heavy chain, ...
著者Cai, Z, Zhu, Z, Liu, Q, Greene, M.I.
登録日2014-09-03
公開日2015-12-16
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Atomic description of the immune complex involved in heparin-induced thrombocytopenia.
Nat Commun, 6, 2015
4R9W
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BU of 4r9w by Molmil
Crystal structure of platelet factor 4 complexed with fondaparinux
分子名称: 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranoside, Platelet factor 4
著者Cai, Z, Zhu, Z, Liu, Q, Greene, M.I.
登録日2014-09-08
公開日2015-12-16
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Atomic description of the immune complex involved in heparin-induced thrombocytopenia.
Nat Commun, 6, 2015
4R9Y
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BU of 4r9y by Molmil
Crystal structure of KKOFab in complex with platelet factor 4
分子名称: Platelet factor 4, Platelet factor 4 antibody KKO heavy chain, Platelet factor 4 antibody KKO light chain
著者Cai, Z, Zhu, Z, Liu, Q, Greene, M.I.
登録日2014-09-08
公開日2015-12-16
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (4.11 Å)
主引用文献Atomic description of the immune complex involved in heparin-induced thrombocytopenia.
Nat Commun, 6, 2015
4XI5
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BU of 4xi5 by Molmil
gHgL of varicella-zoster virus in complex with human neutralizing antibodies
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein H, Envelope glycoprotein L, ...
著者Xing, Y.
登録日2015-01-06
公開日2015-05-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.9 Å)
主引用文献A site of varicella-zoster virus vulnerability identified by structural studies of neutralizing antibodies bound to the glycoprotein complex gHgL.
Proc.Natl.Acad.Sci.USA, 112, 2015
4XHJ
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BU of 4xhj by Molmil
gHgL of Varicella-zoster virus in complex with human neutralizing antibodies.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein H, ...
著者Xing, Y.
登録日2015-01-05
公開日2015-05-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.156 Å)
主引用文献A site of varicella-zoster virus vulnerability identified by structural studies of neutralizing antibodies bound to the glycoprotein complex gHgL.
Proc.Natl.Acad.Sci.USA, 112, 2015
5HCV
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BU of 5hcv by Molmil
Identification of Spirooxindole and Dibenzoxazepine Motifs as Potent Mineralocorticoid Receptor Antagonists
分子名称: 6-[(~{E})-(3-fluoranyl-6~{H}-benzo[c][1]benzoxepin-11-ylidene)methyl]-4~{H}-1,4-benzoxazin-3-one, CHLORIDE ION, Mineralocorticoid receptor
著者Chen, G, McKeever, B.M.
登録日2016-01-04
公開日2016-03-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists.
Bioorg.Med.Chem., 24, 2016
5I4V
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BU of 5i4v by Molmil
Discovery of novel, orally efficacious Liver X Receptor (LXR) beta agonists
分子名称: Oxysterols receptor LXR-beta,Nuclear receptor coactivator 2, Retinoic acid receptor RXR-beta,Nuclear receptor coactivator 2, {2-[(2R)-4-[4-(hydroxymethyl)-3-(methylsulfonyl)phenyl]-2-(propan-2-yl)piperazin-1-yl]-4-(trifluoromethyl)pyrimidin-5-yl}methanol
著者Chen, G, McKeever, B.M.
登録日2016-02-12
公開日2016-06-29
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) beta Agonist.
J.Med.Chem., 59, 2016
8P5E
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BU of 8p5e by Molmil
S. cerevisiae nexus-sCMGE after DNA replication initiation
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, ...
著者Henrikus, S.S, Willhoft, O.
登録日2023-05-24
公開日2024-05-29
最終更新日2024-08-28
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Unwinding of a eukaryotic origin of replication visualized by cryo-EM.
Nat.Struct.Mol.Biol., 31, 2024
8P62
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BU of 8p62 by Molmil
S. cerevisiae ssDNA-sCMGE after DNA replication initiation
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, ...
著者Henrikus, S.S, Willhoft, O.
登録日2023-05-25
公開日2024-05-29
最終更新日2024-08-28
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Unwinding of a eukaryotic origin of replication visualized by cryo-EM.
Nat.Struct.Mol.Biol., 31, 2024
8P63
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BU of 8p63 by Molmil
S. cerevisiae consensus-sCMGE on ssDNA after DNA replication initiation
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, ...
著者Henrikus, S.S, Willhoft, O.
登録日2023-05-25
公開日2024-05-29
最終更新日2024-08-28
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Unwinding of a eukaryotic origin of replication visualized by cryo-EM.
Nat.Struct.Mol.Biol., 31, 2024
2VPR
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BU of 2vpr by Molmil
Tet repressor class H in complex with 5a,6- anhydrotetracycline-Mg
分子名称: 5A,6-ANHYDROTETRACYCLINE, MAGNESIUM ION, SULFATE ION, ...
著者Schuldt, L, Palm, G, Hinrichs, W.
登録日2008-03-03
公開日2008-03-11
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Tet Repressor Induction by Tetracycline: A Molecular Dynamics, Continuum Electrostatics, and Crystallographic Study
J.Mol.Biol., 378, 2008

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件を2024-08-28に公開中

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