3W7G
| Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-5-013 | 分子名称: | 5-[2-(2-methoxyphenyl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... | 著者 | Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Hashimoto, S, Matsuoka, S, Kuranaga, T, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. | 登録日 | 2013-02-28 | 公開日 | 2014-03-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-5-013 To be Published
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3W7M
| Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with TT2-3-063 | 分子名称: | 5-{2-[6-(methoxycarbonyl)naphthalen-2-yl]ethyl}-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... | 著者 | Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Hashimoto, S, Matsuoka, S, Kuranaga, T, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. | 登録日 | 2013-03-02 | 公開日 | 2014-03-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with TT2-3-063 To be Published
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3W74
| Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-139 | 分子名称: | 2,6-dioxo-5-{2-[4-(trifluoromethoxy)phenyl]ethyl}-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... | 著者 | Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Hashimoto, S, Matsuoka, S, Kuranaga, T, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. | 登録日 | 2013-02-27 | 公開日 | 2014-03-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-139 To be Published
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3W7E
| Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-5-179 | 分子名称: | 5-[2-(7-methoxynaphthalen-1-yl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... | 著者 | Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Hashimoto, S, Matsuoka, S, Kuranaga, T, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. | 登録日 | 2013-02-28 | 公開日 | 2014-03-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-5-179 To be Published
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3W87
| Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with SH-1-103 | 分子名称: | 1,2-ETHANEDIOL, 5-{4-[5-(methoxycarbonyl)naphthalen-2-yl]butyl}-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, CACODYLATE ION, ... | 著者 | Inaoka, D.K, Hashimoto, S, Rocha, J.R, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Kuranaga, T, Shiba, T, Balogun, E.O, Sakamoto, K, Suzuki, S, Montanari, C.A, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. | 登録日 | 2013-03-12 | 公開日 | 2014-04-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with SH-1-103 To be Published
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3VRA
| Mitochondrial rhodoquinol-fumarate reductase from the parasitic nematode Ascaris suum with the specific inhibitor Atpenin A5 | 分子名称: | 3-[(2S,4S,5R)-5,6-DICHLORO-2,4-DIMETHYL-1-OXOHEXYL]-4-HYDROXY-5,6-DIMETHOXY-2(1H)-PYRIDINONE, Cytochrome b-large subunit, FE2/S2 (INORGANIC) CLUSTER, ... | 著者 | Shimizu, H, Shiba, T, Inaoka, D.K, Osanai, A, Kita, K, Sakamoto, K, Harada, S. | 登録日 | 2012-04-07 | 公開日 | 2013-04-10 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.44 Å) | 主引用文献 | Crystal structure of mitochondrial quinol-fumarate reductase from parasitic nematode Ascaris suum To be Published
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3VR9
| Mitochondrial rhodoquinol-fumarate reductase from the parasitic nematode Ascaris suum with the specific inhibitor flutolanil | 分子名称: | Cytochrome b-large subunit, FE2/S2 (INORGANIC) CLUSTER, FE3-S4 CLUSTER, ... | 著者 | Shimizu, H, Shiba, T, Inaoka, D.K, Osanai, A, Kita, K, Sakamoto, K, Harada, S. | 登録日 | 2012-04-07 | 公開日 | 2013-04-10 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | 主引用文献 | Crystal structure of mitochondrial quinol-fumarate reductase from parasitic nematode Ascaris suum To be Published
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3W1N
| Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-iodoorotate | 分子名称: | 5-iodo-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... | 著者 | Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. | 登録日 | 2012-11-19 | 公開日 | 2013-11-20 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-iodoorotate To be Published
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3W3O
| Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-053 | 分子名称: | 5-[2-(6-methoxynaphthalen-2-yl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... | 著者 | Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Rocha, J.R, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. | 登録日 | 2012-12-27 | 公開日 | 2014-01-01 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-053 To be Published
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3W76
| Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-189 | 分子名称: | 5-[2-(3-methoxyphenyl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... | 著者 | Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Hashimoto, S, Matsuoka, S, Kuranaga, T, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. | 登録日 | 2013-02-27 | 公開日 | 2014-03-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-189 To be Published
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3W7H
| Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-5-015 | 分子名称: | 5-[2-(naphthalen-2-yl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... | 著者 | Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Hashimoto, S, Matsuoka, S, Kuranaga, T, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. | 登録日 | 2013-02-28 | 公開日 | 2014-03-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-5-015 To be Published
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3W7K
| Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-6-066 | 分子名称: | 5-[2-(3,6-dimethoxynaphthalen-2-yl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... | 著者 | Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Hashimoto, S, Matsuoka, S, Kuranaga, T, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. | 登録日 | 2013-02-28 | 公開日 | 2014-03-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-6-066 To be Published
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3W84
| Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-6-101 | 分子名称: | 5-{2-[3-(methoxymethoxy)naphthalen-2-yl]ethyl}-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... | 著者 | Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Hashimoto, S, Matsuoka, S, Kuranaga, T, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. | 登録日 | 2013-03-12 | 公開日 | 2014-03-12 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-6-101 To be Published
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3WXK
| Crystal structure of trypanosoma brucei gambiense glycerol kinase in complex with glycerol | 分子名称: | GLYCEROL, Glycerol kinase, HEXANE-1,6-DIOL | 著者 | Balogun, E.O, Inaoka, D.K, Shiba, T, Kido, Y, Tsuge, C, Nara, T, Aoki, T, Honma, T, Tanaka, A, Inoue, M, Matsuoka, S, Michels, P.A.M, Kita, K, Harada, S. | 登録日 | 2014-08-01 | 公開日 | 2014-12-24 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | 主引用文献 | Molecular basis for the reverse reaction of African human trypanosomes glycerol kinase. Mol.Microbiol., 94, 2014
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3WXL
| Crystal structure of trypanosoma brucei gambiense glycerol kinase complex with adp, mg2+, and glycerol | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Glycerol kinase, ... | 著者 | Balogun, E.O, Inaoka, D.K, Shiba, T, Kido, Y, Tsuge, C, Nara, T, Aoki, T, Honma, T, Tanaka, A, Inoue, M, Matsuoka, S, Michels, P.A.M, Kita, K, Harada, S. | 登録日 | 2014-08-01 | 公開日 | 2014-12-24 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Molecular basis for the reverse reaction of African human trypanosomes glycerol kinase. Mol.Microbiol., 94, 2014
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3WXI
| Crystal structure of trypanosoma brucei gambiense glycerol kinase (ligand-free form) | 分子名称: | Glycerol kinase | 著者 | Balogun, E.O, Inaoka, D.K, Shiba, T, Kido, Y, Tsuge, T, Nara, T, Aoki, T, Honma, T, Tanaka, A, Inoue, M, Matsuoka, S, Michels, P.A.M, Kita, K, Harada, S. | 登録日 | 2014-08-01 | 公開日 | 2014-12-24 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Molecular basis for the reverse reaction of African human trypanosomes glycerol kinase. Mol.Microbiol., 94, 2014
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3WXJ
| Crystal structure of trypanosoma brucei gambiense glycerol kinase in complex with glycerol 3-phosphate | 分子名称: | GLYCEROL, Glycerol kinase, SN-GLYCEROL-3-PHOSPHATE | 著者 | Balogun, E.O, Inaoka, D.K, Shiba, T, Kido, Y, Tsuge, C, Nara, T, Aoki, T, Honma, T, Tanaka, A, Inoue, M, Matsuoka, S, Michels, P.A.M, Kita, K, Harada, S. | 登録日 | 2014-08-01 | 公開日 | 2014-12-31 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Molecular basis for the reverse reaction of African human trypanosomes glycerol kinase. Mol.Microbiol., 94, 2014
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5B1S
| Crystal structure of Trypanosoma cruzi spermidine synthase in complex with 2-(2-fluorophenyl)ethanamine | 分子名称: | 2-(2-fluorophenyl)ethanamine, 5'-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5'-DEOXYADENOSINE, Spermidine synthase, ... | 著者 | Amano, Y, Tateishi, Y. | 登録日 | 2015-12-17 | 公開日 | 2016-12-21 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease Sci Rep, 7, 2017
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6G3B
| AvaII restriction endonuclease in complex with an RNA/DNA hybrid | 分子名称: | DNA (5'-D(*CP*CP*AP*TP*GP*GP*TP*CP*CP*TP*A)-3'), RNA (5'-R(P*GP*UP*AP*GP*GP*AP*CP*CP*AP*UP*G)-3'), Type II site-specific deoxyribonuclease | 著者 | Kisiala, M, Kowalska, M, Czapinska, H, Bochtler, M. | 登録日 | 2018-03-24 | 公開日 | 2019-04-10 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Restriction endonucleases that cleave RNA/DNA heteroduplexes bind dsDNA in A-like conformation Nucleic Acids Res., 2020
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6S48
| AvaII RESTRICTION ENDONUCLEASE IN COMPLEX WITH PARTIALLY CLEAVED dsDNA | 分子名称: | BETA-MERCAPTOETHANOL, CALCIUM ION, DNA (5'-D(*GP*AP*TP*G)-3'), ... | 著者 | Kisiala, M, Kowalska, M, Korza, H, Czapinska, H, Bochtler, M. | 登録日 | 2019-06-26 | 公開日 | 2020-05-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Restriction endonucleases that cleave RNA/DNA heteroduplexes bind dsDNA in A-like conformation. Nucleic Acids Res., 48, 2020
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6S58
| AvaII restriction endonuclease in the absence of nucleic acids | 分子名称: | CALCIUM ION, Type II site-specific deoxyribonuclease, UNKNOWN ATOM OR ION | 著者 | Kisiala, M, Kowalska, M, Korza, H, Czapinska, H, Bochtler, M. | 登録日 | 2019-06-30 | 公開日 | 2020-05-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Restriction endonucleases that cleave RNA/DNA heteroduplexes bind dsDNA in A-like conformation. Nucleic Acids Res., 48, 2020
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5Y4P
| Crystal structure of Trypanosoma cruzi spermidine synthase in complex with 5-methoxy-2-(5-methyl-4,5-dihydro-1H-imidazol-2-yl)phenol | 分子名称: | 5'-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5'-DEOXYADENOSINE, 5-methoxy-2-[(5R)-5-methyl-4,5-dihydro-1H-imidazol-2-yl]phenol, Spermidine synthase, ... | 著者 | Amano, Y, Tateishi, Y. | 登録日 | 2017-08-04 | 公開日 | 2018-08-08 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | 主引用文献 | Discovery of a Hidden Trypanosoma cruzi Spermidine Synthase Binding Site and Inhibitors through In Silico, In Vitro , and X-ray Crystallography. Acs Omega, 8, 2023
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5Y4Q
| Crystal structure of Trypanosoma cruzi spermidine synthase in complex with N-(4-methoxyphenyl)quinolin-4-amine | 分子名称: | 5'-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5'-DEOXYADENOSINE, N-(4-methoxyphenyl)quinolin-4-amine, Spermidine synthase, ... | 著者 | Amano, Y, Tateishi, Y. | 登録日 | 2017-08-04 | 公開日 | 2018-08-08 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Discovery of a Hidden Trypanosoma cruzi Spermidine Synthase Binding Site and Inhibitors through In Silico, In Vitro , and X-ray Crystallography. Acs Omega, 8, 2023
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2ZYZ
| Pyrobaculum aerophilum splicing endonuclease | 分子名称: | Putative uncharacterized protein PAE0789, tRNA-splicing endonuclease | 著者 | Yoshinari, S, Inaoka, D.K, Watanabe, Y, Shiba, T, Kurisu, G, Harada, S. | 登録日 | 2009-01-30 | 公開日 | 2009-06-23 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Functional importance of crenarchaea-specific extra-loop revealed by an X-ray structure of a heterotetrameric crenarchaeal splicing endonuclease Nucleic Acids Res., 37, 2009
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3AJV
| Splicing endonuclease from Aeropyrum pernix | 分子名称: | CHLORIDE ION, GLYCEROL, Putative uncharacterized protein, ... | 著者 | Yoshinari, S, Watanabe, Y, Okuda, M, Shiba, T, Inaoka, K.D, Kurisu, G. | 登録日 | 2010-06-19 | 公開日 | 2010-11-17 | 最終更新日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | A Conserved Lysine Residue in the Crenarchaea-Specific Loop is Important for the Crenarchaeal Splicing Endonuclease Activity. J.Mol.Biol., 405, 2011
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