3W7G

Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-5-013

Summary for 3W7G

• Entry DOI: 10.2210/pdb3w7g/pdb
• Related: 3W1A 3W1L 3W1M 3W1N 3W1P 3W1Q 3W1R 3W1T 3W1U 3W1X 3W22 3W23 3W2J 3W2K 3W2L 3W2M 3W2N 3W2U 3W6Y 3W70 3W71 3W72 3W73 3W74 3W75 3W76 3W7C 3W7D 3W7E 4JD4 4JDB
• Descriptor: Dihydroorotate dehydrogenase (fumarate), 5-[2-(2-methoxyphenyl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, GLYCEROL, ... (6 entities in total)
• Functional Keywords: rossmann fold, oxidoreductase, dihydroorotate/orotate and fumarate/succinate binding, cytosol, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Trypanosoma cruzi
• Cellular location: Cytoplasm : Q4D3W2
• Total number of polymer chains: 2
• Total formula weight: 71078.14

Authors

Inaoka, D.K.,Iida, M.,Tabuchi, T.,Lee, N.,Hashimoto, S.,Matsuoka, S.,Kuranaga, T.,Shiba, T.,Sakamoto, K.,Suzuki, S.,Balogun, E.O.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K. (deposition date: 2013-02-28, release date: 2014-03-05, Last modification date: 2024-10-30)

• Primary citation: Inaoka, D.K.,Iida, M.,Tabuchi, T.,Lee, N.,Hashimoto, S.,Matsuoka, S.,Kuranaga, T.,Shiba, T.,Sakamoto, K.,Suzuki, S.,Balogun, E.O.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K.; Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-5-013; To be Published,

Experimental method

X-RAY DIFFRACTION (1.55 Å)