4JDB
Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-5-005
Summary for 4JDB
Entry DOI | 10.2210/pdb4jdb/pdb |
Related | 3W1A 3W1L 3W1M 3W1N 3W1P 3W1Q 3W1R 3W1T 3W1U 3W1X 3W22 3W23 3W2J 3W2K 3W2L 3W2M 3W2N 3W2U 4JD4 |
Descriptor | Dihydroorotate dehydrogenase (fumarate), 5-[2-(7-methoxynaphthalen-2-yl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, GLYCEROL, ... (6 entities in total) |
Functional Keywords | rossmann fold, oxidoreductase, dihydroorotate/orotate and fumarate/succinate binding, cytosol, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Trypanosoma cruzi |
Cellular location | Cytoplasm : Q4D3W2 |
Total number of polymer chains | 2 |
Total formula weight | 71178.26 |
Authors | Inaoka, D.K.,Iida, M.,Tabuchi, T.,Lee, N.,Hashimoto, S.,Matsuoka, S.,Kuranaga, T.,Shiba, T.,Sakamoto, K.,Suzuki, S.,Balogun, E.O.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K. (deposition date: 2013-02-24, release date: 2014-02-26, Last modification date: 2023-11-08) |
Primary citation | Inaoka, D.K.,Iida, M.,Tabuchi, T.,Lee, N.,Hashimoto, S.,Matsuoka, S.,Kuranaga, T.,Shiba, T.,Sakamoto, K.,Suzuki, S.,Balogun, E.O.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K. Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-5-005 To be Published, |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
Download full validation report