3W75

Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-149

Summary for 3W75

• Entry DOI: 10.2210/pdb3w75/pdb
• Related: 3W1A 3W1L 3W1M 3W1N 3W1P 3W1Q 3W1R 3W1T 3W1U 3W1X 3W22 3W23 3W2J 3W2K 3W2L 3W2M 3W2N 3W2U 3W6Y 3W70 3W71 3W72 3W73 3W74 4JD4 4JDB
• Descriptor: Dihydroorotate dehydrogenase (fumarate), 5-[2-(3,5-dimethoxyphenyl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, GLYCEROL, ... (6 entities in total)
• Functional Keywords: rossmann fold, oxidoreductase, dihydroorotate/orotate and fumarate/succinate binding, cytosol, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Trypanosoma cruzi
• Cellular location: Cytoplasm : Q4D3W2
• Total number of polymer chains: 2
• Total formula weight: 71230.28

Authors

Inaoka, D.K.,Iida, M.,Tabuchi, T.,Lee, N.,Hashimoto, S.,Matsuoka, S.,Kuranaga, T.,Shiba, T.,Sakamoto, K.,Suzuki, S.,Balogun, E.O.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K. (deposition date: 2013-02-27, release date: 2014-03-05, Last modification date: 2024-10-09)

• Primary citation: Inaoka, D.K.,Iida, M.,Tabuchi, T.,Lee, N.,Hashimoto, S.,Matsuoka, S.,Kuranaga, T.,Shiba, T.,Sakamoto, K.,Suzuki, S.,Balogun, E.O.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K.; Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-149; To be Published,

Experimental method

X-RAY DIFFRACTION (1.47 Å)