2YW9
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7NS0
| Bacilladnavirus capsid structure | 分子名称: | Capsid protein VP2 | 著者 | Munke, A, Okamoto, K. | 登録日 | 2021-03-05 | 公開日 | 2022-07-20 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Primordial Capsid and Spooled ssDNA Genome Structures Unravel Ancestral Events of Eukaryotic Viruses. Mbio, 13, 2022
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8ABX
| Crystal structure of IDO1 in complex with Apoxidole-1 | 分子名称: | Indoleamine 2,3-dioxygenase 1, O1-tert-butyl O2-ethyl O5-methyl (E,5R)-5-(1-methylindol-2-yl)-5-[(4-methylphenyl)sulfonylamino]pent-2-ene-1,2,5-tricarboxylate, O2-tert-butyl O3-ethyl O6-methyl (2S,6R)-6-(1-methylindol-2-yl)-2,5-dihydro-1H-pyridine-2,3,6-tricarboxylate, ... | 著者 | Dotsch, L, Ziegler, S, Waldmann, H, Gasper, R. | 登録日 | 2022-07-05 | 公開日 | 2022-08-24 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Identification of a Novel Pseudo-Natural Product Type IV IDO1 Inhibitor Chemotype. Angew.Chem.Int.Ed.Engl., 61, 2022
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7VSG
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7VSH
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7ZZX
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8CRH
| Crystal structure of Candida auris dihydrofolate reductase complexed with NADPH and cycloguanil | 分子名称: | 5-(4-chlorophenyl)-6,6-dimethyl-1,4-dihydro-1,3,5-triazine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Kirkman, T.J, Dias, M.V.B. | 登録日 | 2023-03-08 | 公開日 | 2023-08-02 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Crystal structure of dihydrofolate reductase from the emerging pathogenic fungus Candida auris. Acta Crystallogr D Struct Biol, 79, 2023
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7M3Z
| Structure of TIM-3 in complex with N-(4-(8-chloro-2-mehtyl-5-oxo-5,6-dihydro-[1,2,4]triazolo[1,5-c]quinazolin-9-yl)-3-methylphenyl)methanesulfonamdide (compound 35) | 分子名称: | CALCIUM ION, Hepatitis A virus cellular receptor 2, N-{4-[(4S,10aP)-8-chloro-2-methyl-5-oxo-5,6-dihydro[1,2,4]triazolo[1,5-c]quinazolin-9-yl]-3-methylphenyl}methanesulfonamide | 著者 | Rietz, T.A. | 登録日 | 2021-03-19 | 公開日 | 2021-10-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Fragment-Based Discovery of Small Molecules Bound to T-Cell Immunoglobulin and Mucin Domain-Containing Molecule 3 (TIM-3). J.Med.Chem., 64, 2021
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7M3Y
| Structure of TIM-3 in complex with 8-chloro-2-methyl-9-(3-mehtylpyridin-4-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one (compound 22) | 分子名称: | (4R,10aP)-8-chloro-2-methyl-9-(3-methylpyridin-4-yl)[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one, CALCIUM ION, Hepatitis A virus cellular receptor 2 | 著者 | Rietz, T.A. | 登録日 | 2021-03-19 | 公開日 | 2021-10-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Fragment-Based Discovery of Small Molecules Bound to T-Cell Immunoglobulin and Mucin Domain-Containing Molecule 3 (TIM-3). J.Med.Chem., 64, 2021
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7M41
| Structure of TIM-3 in complex with N-(4-(8-chloro-2-methyl-5-oxo-5,6-dihydro-[1,2,4]traizolo[1,5-c]quinazolin-9-yl)-3-methylphenyl)-1H-imidazole-2-sulfonamide (compound 38) | 分子名称: | CALCIUM ION, Hepatitis A virus cellular receptor 2, N-{4-[(4S,10aP)-8-chloro-2-methyl-5-oxo-5,6-dihydro[1,2,4]triazolo[1,5-c]quinazolin-9-yl]-3-methylphenyl}-1H-imidazole-2-sulfonamide | 著者 | Rietz, T.A. | 登録日 | 2021-03-19 | 公開日 | 2021-10-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Fragment-Based Discovery of Small Molecules Bound to T-Cell Immunoglobulin and Mucin Domain-Containing Molecule 3 (TIM-3). J.Med.Chem., 64, 2021
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5IT2
| Structure of a transglutaminase 2-specific autoantibody 693-10-B06 Fab fragment | 分子名称: | heavy chain, light chain | 著者 | Chen, X, Dalhus, B, Hnida, K, Iversen, R, Sollid, L.M. | 登録日 | 2016-03-16 | 公開日 | 2017-03-22 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions Nat. Med., 18, 2012
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6Q0D
| CRYSTAL STRUCTURE OF LDHA IN COMPLEX WITH COMPOUND NCGC00384414-01 AT 2.05 A RESOLUTION | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-{3-[3-(cyclopentylethynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid, GLYCEROL, ... | 著者 | Dranow, D.M, Davies, D.R. | 登録日 | 2019-08-01 | 公開日 | 2020-09-23 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties. J.Med.Chem., 63, 2020
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6Q13
| CRYSTAL STRUCTURE OF LDHA IN COMPLEX WITH COMPOUND NCGC00420737-09 AT 2.00 A RESOLUTION | 分子名称: | 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-{3-[(5-methylthiophen-2-yl)ethynyl]phenyl}-1H-pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid, ... | 著者 | Davies, D.R, Dranow, D.M. | 登録日 | 2019-08-02 | 公開日 | 2020-09-23 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties. J.Med.Chem., 63, 2020
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5W8I
| Crystal Structure of Lactate Dehydrogenase A in complex with inhibitor compound 23 and Zinc | 分子名称: | 2-[3-(3,4-difluorophenyl)-5-hydroxy-1H-pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid, CITRIC ACID, DIMETHYL SULFOXIDE, ... | 著者 | Lukacs, C.M, Abendroth, J. | 登録日 | 2017-06-21 | 公開日 | 2018-01-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). J. Med. Chem., 60, 2017
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5W8L
| Crystal Structure of Lactate Dehydrogenase A in complex with inhibitor compound 59 and NADH | 分子名称: | 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-{3-([1,1'-biphenyl]-3-yl)-5-(cyclopropylmethyl)-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid, ... | 著者 | Davies, D.R, Dranow, D.M. | 登録日 | 2017-06-21 | 公開日 | 2018-01-17 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). J. Med. Chem., 60, 2017
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5W8J
| Crystal Structure of Lactate Dehydrogenase A in complex with inhibitor compound 29 | 分子名称: | 2-{3-(3,4-difluorophenyl)-5-hydroxy-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Lukacs, C.M, Moulin, A. | 登録日 | 2017-06-21 | 公開日 | 2018-01-17 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). J. Med. Chem., 60, 2017
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5WRL
| Mu2 subunit of the clathrin adaptor complex AP2 in complex with IRS-1 Y628 peptide | 分子名称: | AP-2 complex subunit mu, Insulin receptor substrate 1 | 著者 | Yoneyama, Y, Niwa, H, Umehara, T, Yokoyama, S, Hakuno, F, Takahashi, S. | 登録日 | 2016-12-02 | 公開日 | 2017-12-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.095 Å) | 主引用文献 | IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling Elife, 7, 2018
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5WRK
| Mu2 subunit of the clathrin adaptor complex AP2 in complex with IRS-1 Y608 peptide | 分子名称: | AP-2 complex subunit mu, Insulin receptor substrate 1, NICKEL (II) ION | 著者 | Yoneyama, Y, Niwa, H, Umehara, T, Yokoyama, S, Hakuno, F, Takahashi, S. | 登録日 | 2016-12-02 | 公開日 | 2017-12-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling Elife, 7, 2018
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5W8H
| Crystal Structure of Lactate Dehydrogenase A in complex with inhibitor compound 11 | 分子名称: | 2-[3-(4-fluorophenyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid, ACETATE ION, DIMETHYL SULFOXIDE, ... | 著者 | Lukacs, C.M, Dranow, D.M. | 登録日 | 2017-06-21 | 公開日 | 2018-01-17 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). J. Med. Chem., 60, 2017
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5W8K
| Crystal Structure of Lactate Dehydrogenase A in complex with inhibitor compound 29 and NADH | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-{3-(3,4-difluorophenyl)-5-hydroxy-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid, GLYCEROL, ... | 著者 | Lukacs, C.M, Dranow, D.M. | 登録日 | 2017-06-21 | 公開日 | 2018-01-17 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). J. Med. Chem., 60, 2017
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5WRM
| Mu2 subunit of the clathrin adaptor complex AP2 in complex with IRS-1 Y658 peptide | 分子名称: | AP-2 complex subunit mu, Insulin receptor substrate 1 | 著者 | Yoneyama, Y, Niwa, H, Umehara, T, Yokoyama, S, Hakuno, F, Takahashi, S. | 登録日 | 2016-12-02 | 公開日 | 2017-12-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.597 Å) | 主引用文献 | IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling Elife, 7, 2018
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1AQ7
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6HUS
| 2'-fucosyllactose and 3-fucosyllactose binding protein from Bifidobacterium longum infantis, bound with 3-fucosyllactose | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ABC transporter substrate-binding protein, ZINC ION, ... | 著者 | Ejby, M, Abou Hachem, M, Lo Leggio, L, Takane, K, Sakanaka, M. | 登録日 | 2018-10-09 | 公開日 | 2019-09-04 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.409 Å) | 主引用文献 | Evolutionary adaptation in fucosyllactose uptake systems supports bifidobacteria-infant symbiosis. Sci Adv, 5, 2019
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5ZLQ
| Crystal Structure of C1orf123 | 分子名称: | UPF0587 protein C1orf123, ZINC ION | 著者 | Furukawa, Y, Lim, C.T, Tosha, T. | 登録日 | 2018-03-29 | 公開日 | 2018-10-10 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Identification of a novel zinc-binding protein, C1orf123, as an interactor with a heavy metal-associated domain PLoS ONE, 13, 2018
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6KB8
| X-ray structure of human PPARalpha ligand binding domain-GW7647 co-crystals obtained by cross-seeding | 分子名称: | 2-[(4-{2-[(4-cyclohexylbutyl)(cyclohexylcarbamoyl)amino]ethyl}phenyl)sulfanyl]-2-methylpropanoic acid, GLYCEROL, Peroxisome proliferator-activated receptor alpha | 著者 | Kamata, S, Suda, K, Saito, K, Oyama, T, Ishii, I. | 登録日 | 2019-06-24 | 公開日 | 2020-11-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23, 2020
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