5IT2

Structure of a transglutaminase 2-specific autoantibody 693-10-B06 Fab fragment

Summary for 5IT2

• Entry DOI: 10.2210/pdb5it2/pdb
• Descriptor: heavy chain, light chain (3 entities in total)
• Functional Keywords: transglutaminase 2, autoantibody, fab fragment, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 47889.53

Authors

Chen, X.,Dalhus, B.,Hnida, K.,Iversen, R.,Sollid, L.M. (deposition date: 2016-03-16, release date: 2017-03-22, Last modification date: 2023-11-08)

• Primary citation: Di Niro, R.,Mesin, L.,Zheng, N.Y.,Stamnaes, J.,Morrissey, M.,Lee, J.H.,Huang, M.,Iversen, R.,du Pre, M.F.,Qiao, S.W.,Lundin, K.E.,Wilson, P.C.,Sollid, L.M.; High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions; Nat. Med., 18:441-445, 2012; PubMed: 22366952; DOI: 10.1038/nm.2656

Experimental method

X-RAY DIFFRACTION (1.7 Å)