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Solution structure of T-cell surface glycoprotein CD8 alpha chain and Proto-oncogene tyrosine-protein kinase LCK fragments
分子名称:	Proto-oncogene tyrosine-protein kinase LCK, T-cell surface glycoprotein CD8 alpha chain, ZINC ION
著者	Kim, P.W, Sun, Z.Y, Blacklow, S.C, Wagner, G, Eck, M.J.
登録日	2003-08-12
公開日	2003-11-25
最終更新日	2024-05-22
実験手法	SOLUTION NMR
主引用文献	A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. Science, 301, 2003

7JXQ

EGFR kinase (T790M/V948R) in complex with allosteric inhibitor JBJ-09-063
分子名称:	(2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ...
著者	Beyett, T.S, Eck, M.J.
登録日	2020-08-27
公開日	2021-09-08
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (1.83 Å)
主引用文献	An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer. Nat Cancer, 3, 2022

7JXH

HER2 in complex with JBJ-08-178-01
分子名称:	(2E)-N-[3-cyano-7-ethoxy-4-({3-methyl-4-[([1,2,4]triazolo[1,5-a]pyridin-7-yl)oxy]phenyl}amino)quinolin-6-yl]-4-(dimethylamino)but-2-enamide, Receptor tyrosine-protein kinase erbB-2
著者	Beyett, T.S, Eck, M.J.
登録日	2020-08-27
公開日	2021-09-08
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (3.27 Å)
主引用文献	A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non-Small Cell Lung Cancer. Cancer Res., 82, 2022

2JKK

Focal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor
分子名称:	2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE, FOCAL ADHESION KINASE 1, SULFATE ION
著者	Lietha, D, Eck, M.J.
登録日	2008-08-28
公開日	2008-09-09
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Crystal Structures of the Fak Kinase in Complex with Tae226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical Dfg Conformation. Plos One, 3, 2008

2JKQ

Focal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor
分子名称:	4-(1,4'-bipiperidin-1'-yl)-7-({5-chloro-2-[(2-methoxyphenyl)amino]pyrimidin-4-yl}amino)-2-methyl-2,3-dihydro-1H-isoindol-1-one, FOCAL ADHESION KINASE 1
著者	Lietha, D, Eck, M.J.
登録日	2008-08-29
公開日	2008-09-09
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Crystal Structures of the Fak Kinase in Complex with Tae226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical Dfg Conformation. Plos One, 3, 2008

2JIU

Crystal structure of EGFR kinase domain T790M mutation in complex with AEE788
分子名称:	6-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]PHENYL}-N-[(1R)-1-PHENYLETHYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE, EPIDERMAL GROWTH FACTOR RECEPTOR
著者	Yun, C.-H, Mengwasser, K.E, Toms, A.V, Woo, M.S, Greulich, H, Wong, K.-K, Meyerson, M, Eck, M.J.
登録日	2007-07-01
公開日	2008-01-22
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (3.05 Å)
主引用文献	The T790M Mutation in Egfr Kinase Causes Drug Resistance by Increasing the Affinity for ATP. Proc.Natl.Acad.Sci.USA, 105, 2008

2JIT

Crystal structure of EGFR kinase domain T790M mutation
分子名称:	EPIDERMAL GROWTH FACTOR RECEPTOR
著者	Yun, C.-H, Mengwasser, K.E, Toms, A.V, Woo, M.S, Greulich, H, Wong, K.-K, Meyerson, M, Eck, M.J.
登録日	2007-07-01
公開日	2008-01-22
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (3.1 Å)
主引用文献	The T790M Mutation in Egfr Kinase Causes Drug Resistance by Increasing the Affinity for ATP. Proc.Natl.Acad.Sci.USA, 105, 2008

2JIV

Crystal structure of EGFR kinase domain T790M mutation in compex with HKI-272
分子名称:	CHLORIDE ION, EPIDERMAL GROWTH FACTOR RECEPTOR, N-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide
著者	Yun, C.-H, Mengwasser, K.E, Toms, A.V, Li, Y, Woo, M.S, Greulich, H, Wong, K.-K, Meyerson, M, Eck, M.J.
登録日	2007-07-02
公開日	2008-01-22
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (3.5 Å)
主引用文献	The T790M Mutation in Egfr Kinase Causes Drug Resistance by Increasing the Affinity for ATP. Proc.Natl.Acad.Sci.USA, 105, 2008

2ITY

Crystal structure of EGFR kinase domain in complex with Iressa
分子名称:	EPIDERMAL GROWTH FACTOR RECEPTOR, Gefitinib
著者	Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J.
登録日	2006-05-25
公開日	2007-04-03
最終更新日	2024-03-27
実験手法	X-RAY DIFFRACTION (3.42 Å)
主引用文献	Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity Cancer Cell, 11, 2007

2ITP

Crystal structure of EGFR kinase domain G719S mutation in complex with AEE788
分子名称:	6-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]PHENYL}-N-[(1R)-1-PHENYLETHYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE, EPIDERMAL GROWTH FACTOR RECEPTOR PRECURSOR
著者	Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J.
登録日	2006-05-25
公開日	2007-04-03
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (2.74 Å)
主引用文献	Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity Cancer Cell, 11, 2007

2ITW

Crystal structure of EGFR kinase domain in complex with AFN941
分子名称:	1,2,3,4-Tetrahydrogen Staurosporine, EPIDERMAL GROWTH FACTOR RECEPTOR
著者	Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J.
登録日	2006-05-25
公開日	2007-04-03
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (2.88 Å)
主引用文献	Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity Cancer Cell, 11, 2007

2ITT

Crystal structure of EGFR kinase domain L858R mutation in complex with AEE788
分子名称:	6-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]PHENYL}-N-[(1R)-1-PHENYLETHYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE, EPIDERMAL GROWTH FACTOR RECEPTOR
著者	Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J.
登録日	2006-05-25
公開日	2007-04-03
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (2.73 Å)
主引用文献	Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity Cancer Cell, 11, 2007

2J0M

Crystal structure a two-chain complex between the FERM and kinase domains of focal adhesion kinase.
分子名称:	1,2,3,4-TETRAHYDROGEN-STAUROSPORINE, FOCAL ADHESION KINASE 1
著者	Lietha, D, Cai, X, Li, Y, Schaller, M.D, Eck, M.J.
登録日	2006-08-03
公開日	2007-07-03
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	Structural Basis for the Autoinhibition of Focal Adhesion Kinase. Cell(Cambridge,Mass.), 129, 2007

2J0K

Crystal structure of a fragment of focal adhesion kinase containing the FERM and kinase domains.
分子名称:	1,2,3,4-TETRAHYDROGEN-STAUROSPORINE, FOCAL ADHESION KINASE 1
著者	Lietha, D, Cai, X, Li, Y, Schaller, M.D, Eck, M.J.
登録日	2006-08-03
公開日	2007-07-03
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (3 Å)
主引用文献	Structural Basis for the Autoinhibition of Focal Adhesion Kinase. Cell(Cambridge,Mass.), 129, 2007

2ITN

Crystal structure of EGFR kinase domain G719S mutation in complex with AMP-PNP
分子名称:	EPIDERMAL GROWTH FACTOR RECEPTOR, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者	Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J.
登録日	2006-05-25
公開日	2007-04-03
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (2.47 Å)
主引用文献	Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity Cancer Cell, 11, 2007

2J0J

Crystal structure of a fragment of focal adhesion kinase containing the FERM and kinase domains.
分子名称:	1,2,3,4-TETRAHYDROGEN-STAUROSPORINE, FOCAL ADHESION KINASE 1
著者	Lietha, D, Cai, X, Li, Y, Schaller, M.D, Eck, M.J.
登録日	2006-08-03
公開日	2007-06-26
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	Structural Basis for the Autoinhibition of Focal Adhesion Kinase Cell(Cambridge,Mass.), 129, 2007

2J0L

Crystal structure of a the active conformation of the kinase domain of focal adhesion kinase with a phosphorylated activation loop.
分子名称:	FOCAL ADHESION KINASE 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者	Lietha, D, Cai, X, Li, Y, Schaller, M.D, Eck, M.J.
登録日	2006-08-03
公開日	2007-06-26
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Structural Basis for the Autoinhibition of Focal Adhesion Kinase Cell(Cambridge,Mass.), 129, 2007

2ITQ

Crystal structure of EGFR kinase domain G719S mutation in complex with AFN941
分子名称:	1,2,3,4-Tetrahydrogen Staurosporine, EPIDERMAL GROWTH FACTOR RECEPTOR
著者	Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J.
登録日	2006-05-25
公開日	2007-04-03
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (2.68 Å)
主引用文献	Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity Cancer Cell, 11, 2007

2ITV

Crystal structure of EGFR kinase domain L858R mutation in complex with AMP-PNP
分子名称:	EPIDERMAL GROWTH FACTOR RECEPTOR, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者	Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J.
登録日	2006-05-25
公開日	2007-04-03
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (2.47 Å)
主引用文献	Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity Cancer Cell, 11, 2007

2J6M

Crystal structure of EGFR kinase domain in complex with AEE788
分子名称:	6-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]PHENYL}-N-[(1R)-1-PHENYLETHYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE, EPIDERMAL GROWTH FACTOR RECEPTOR
著者	Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J.
登録日	2006-09-29
公開日	2007-04-03
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (3.1 Å)
主引用文献	Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity Cancer Cell, 11, 2007

2J5F

Crystal structure of EGFR kinase domain in complex with an irreversible inhibitor 34-jab
分子名称:	EPIDERMAL GROWTH FACTOR RECEPTOR, N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE
著者	Yun, C.-H, Eck, M.J.
登録日	2006-09-14
公開日	2007-02-27
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (3 Å)
主引用文献	Structure-Guided Development of Affinity Probes for Tyrosine Kinases Using Chemical Genetics. Nat.Chem.Biol., 3, 2007

2J1D

Crystallization of hDaam1 C-terminal Fragment
分子名称:	DISHEVELED-ASSOCIATED ACTIVATOR OF MORPHOGENESIS 1, GLYCEROL, PHOSPHATE ION
著者	Lu, J, Meng, W, Poy, F, Eck, M.J.
登録日	2006-08-10
公開日	2007-05-15
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (2.25 Å)
主引用文献	Structure of the Fh2 Domain of Daam1: Implications for Formin Regulation of Actin Assembly. J.Mol.Biol., 369, 2007

2ITZ

Crystal structure of EGFR kinase domain L858R mutation in complex with Iressa
分子名称:	CHLORIDE ION, EPIDERMAL GROWTH FACTOR RECEPTOR, Gefitinib
著者	Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J.
登録日	2006-05-25
公開日	2007-04-03
最終更新日	2024-03-27
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity Cancer Cell, 11, 2007

2ITX

Crystal structure of EGFR kinase domain in complex with AMP-PNP
分子名称:	EPIDERMAL GROWTH FACTOR RECEPTOR, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者	Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J.
登録日	2006-05-25
公開日	2007-04-03
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (2.98 Å)
主引用文献	Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity Cancer Cell, 11, 2007

2ITU

Crystal structure of EGFR kinase domain L858R mutation in complex with AFN941
分子名称:	1,2,3,4-Tetrahydrogen Staurosporine, EPIDERMAL GROWTH FACTOR RECEPTOR
著者	Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J.
登録日	2006-05-25
公開日	2007-04-03
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity Cancer Cell, 11, 2007

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