2JKQ
Focal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor
Summary for 2JKQ
Entry DOI | 10.2210/pdb2jkq/pdb |
Related | 1KTM 1PV3 1QVX 2AEH 2AL6 2J0J 2J0K 2J0L 2J0M 2JKK 2JKM 2JKO |
Descriptor | FOCAL ADHESION KINASE 1, 4-(1,4'-bipiperidin-1'-yl)-7-({5-chloro-2-[(2-methoxyphenyl)amino]pyrimidin-4-yl}amino)-2-methyl-2,3-dihydro-1H-isoindol-1-one (3 entities in total) |
Functional Keywords | transferase, nucleotide-binding, tyrosine-protein kinase, kinase inhibitor, integrin signaling, kinase, atp-binding, cell migration, focal adhesion |
Biological source | GALLUS GALLUS (CHICKEN) |
Total number of polymer chains | 1 |
Total formula weight | 32320.87 |
Authors | Lietha, D.,Eck, M.J. (deposition date: 2008-08-29, release date: 2008-09-09, Last modification date: 2023-12-13) |
Primary citation | Lietha, D.,Eck, M.J. Crystal Structures of the Fak Kinase in Complex with Tae226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical Dfg Conformation. Plos One, 3:E3800-, 2008 Cited by PubMed: 19030106DOI: 10.1371/JOURNAL.PONE.0003800 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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