2JKQ
Focal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | FOCAL ADHESION KINASE 1 | polymer | 276 | 31758.8 | 1 | UniProt (Q00944) Pfam (PF07714) In PDB | GALLUS GALLUS (CHICKEN) | FOCAL ADHESION KINASE, FADK 1 |
| 2 | A | 4-(1,4'-bipiperidin-1'-yl)-7-({5-chloro-2-[(2-methoxyphenyl)amino]pyrimidin-4-yl}amino)-2-methyl-2,3-dihydro-1H-isoindol-1-one | non-polymer | 562.1 | 1 | Chemie (VG8) | |||
| 3 | water | water | 18.0 | 24 | Chemie (HOH) |
Sequence modifications
A: 411 - 686 (UniProt: Q00944)
| PDB | External Database | Details |
|---|---|---|
| Leu 449 | Met 449 | conflict |
| Tyr 516 | Phe 516 | conflict |
| Ser 556 | Ala 556 | conflict |
| Asn 557 | Thr 557 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31758.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 562.1 | |
| All* | Total formula weight | 32320.9 |
