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3Q0K
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BU of 3q0k by Molmil
Crystal structure of Human PACSIN 2 F-BAR
分子名称: CALCIUM ION, Protein kinase C and casein kinase substrate in neurons protein 2
著者Bai, X, Meng, G, Zheng, X.
登録日2010-12-15
公開日2012-02-15
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure of human PACSIN 2 F-BAR domain
To be Published
3QE6
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BU of 3qe6 by Molmil
Mouse PACSIN 3 F-BAR domain structure
分子名称: MAGNESIUM ION, Protein kinase C and casein kinase II substrate protein 3
著者Meng, G, Bai, X, Zheng, X.
登録日2011-01-19
公開日2012-01-25
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Rigidity of wedge loop in PACSIN 3 protein is a key factor in dictating diameters of tubules
J.Biol.Chem., 287, 2012
4ENF
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BU of 4enf by Molmil
Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Puerto Rico/8/34(h1n1)
分子名称: 1,4-BUTANEDIOL, NITRATE ION, Polymerase basic protein 2
著者Meng, G, Liu, Y, Zheng, X.
登録日2012-04-13
公開日2013-03-06
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.32 Å)
主引用文献Structural and functional characterization of K339T substitution identified in the PB2 subunit cap-binding pocket of influenza A virus
J.Biol.Chem., 288, 2013
3QNI
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BU of 3qni by Molmil
Crystal structure of human PACSIN 1 F-BAR domain
分子名称: CALCIUM ION, Protein kinase C and casein kinase substrate in neurons protein 1
著者Meng, G, Bai, X, Zheng, X.
登録日2011-02-08
公開日2011-08-10
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of human PACSIN 1 F-BAR domain
to be published
3REZ
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BU of 3rez by Molmil
glycoprotein GPIb variant
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, Platelet glycoprotein Ib beta chain, ...
著者McEwan, P.A, Yang, W, Carr, K.H, Mo, X, Zheng, X, Li, R, Emsley, J.
登録日2011-04-05
公開日2012-02-15
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIb beta and a GPIb beta/GPIX chimera
Blood, 118, 2011
3RFE
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BU of 3rfe by Molmil
Crystal structure of glycoprotein GPIb ectodomain
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Platelet glycoprotein Ib beta chain, ...
著者McEwan, P.A, Yang, W, Carr, K.H, Mo, X, Zheng, X, Li, R, Emsley, J.
登録日2011-04-06
公開日2011-12-21
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.245 Å)
主引用文献Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbbeta and a GPIbbeta/GPIX chimer
Blood, 118, 2011
4N9B
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BU of 4n9b by Molmil
Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
分子名称: 1-methyl-N-(pyridin-3-yl)-1H-pyrazole-5-carboxamide, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION
著者Dragovich, P.S, Zhao, G, Baumeister, T, Bravo, B, Giannetti, A.M, Ho, Y, Hua, R, Li, G, Liang, X, O'Brien, T, Skelton, N.J, Wang, C, Zhai, Q, Oh, A, Wang, W, Wang, Y, Xiao, Y, Yuen, P, Zak, M, Zheng, X.
登録日2013-10-20
公開日2014-02-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.859 Å)
主引用文献Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 24, 2014
4N9E
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BU of 4n9e by Molmil
Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
分子名称: 1,2-ETHANEDIOL, 1-[(1-benzoylpiperidin-4-yl)methyl]-N-(pyridin-3-yl)-1H-benzimidazole-5-carboxamide, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ...
著者Dragovich, P.S, Zhao, G, Baumeister, T, Bravo, B, Giannetti, A.M, Ho, Y, Hua, R, Li, G, Liang, X, O'Brien, T, Skelton, N.J, Wang, C, Zhao, Q, Oh, A, Wang, W, Wang, Y, Xiao, Y, Yuen, P, Zak, M, Zheng, X.
登録日2013-10-20
公開日2014-02-19
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 24, 2014
4N9D
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BU of 4n9d by Molmil
Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
分子名称: 1,2-ETHANEDIOL, 4-({[(4-tert-butylphenyl)sulfonyl]amino}methyl)-N-(pyridin-3-yl)benzamide, Nicotinamide phosphoribosyltransferase, ...
著者Dragovich, P.S, Zhao, G, Baumeister, T, Bravo, B, Giannetti, A.M, Ho, Y, Hua, R, Li, G, Liang, X, O'Brien, T, Skelton, N.J, Wang, C, Zhao, Q, Oh, A, Wang, W, Wang, Y, Xiao, Y, Yuen, P, Zak, M, Zheng, X.
登録日2013-10-20
公開日2014-02-19
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.701 Å)
主引用文献Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 24, 2014
4N9C
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BU of 4n9c by Molmil
Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
分子名称: 5-nitro-1H-benzimidazole, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION
著者Dragovich, P.S, Zhao, G, Baumeister, T, Bravo, B, Giannetti, A.M, Ho, Y, Hua, R, Li, G, Liang, X, O'Brien, T, Skelton, N.J, Wang, C, Zhao, Q, Oh, A, Wang, W, Wang, Y, Xiao, Y, Yuen, P, Zak, M, Zheng, X.
登録日2013-10-20
公開日2014-02-19
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.751 Å)
主引用文献Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 24, 2014
5A01
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BU of 5a01 by Molmil
O-GlcNAc transferase from Drososphila melanogaster
分子名称: (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, O-GLYCOSYLTRANSFERASE
著者Mariappa, D, Zheng, X, Schimpl, M, Raimi, O, Rafie, K, Ferenbach, A.T, Mueller, H.J, van Aalten, D.M.F.
登録日2015-04-15
公開日2016-04-27
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.66 Å)
主引用文献Dual functionality of O-GlcNAc transferase is required for Drosophila development.
Open Biol, 5, 2015
5EG8
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BU of 5eg8 by Molmil
The cap binding site of influenza virus protein PB2 as a drug target
分子名称: Polymerase basic protein 2, THIOCYANATE ION
著者Liu, Y, Zheng, X, Severin, C, Rocha de Moura, T, Li, K, Luo, M.
登録日2015-10-26
公開日2016-02-10
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献The cap-binding site of influenza virus protein PB2 as a drug target.
Acta Crystallogr D Struct Biol, 72, 2016
5EG7
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BU of 5eg7 by Molmil
The cap binding site of influenza virus protein PB2 as a drug target
分子名称: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, GLYCEROL, Polymerase basic protein 2
著者Severin, C, Rocha de Moura, T, Liu, Y, Li, K, Zheng, X, Luo, M.
登録日2015-10-26
公開日2016-02-10
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献The cap-binding site of influenza virus protein PB2 as a drug target.
Acta Crystallogr D Struct Biol, 72, 2016
5EG9
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BU of 5eg9 by Molmil
The cap binding site of influenza virus protein PB2 as a drug target
分子名称: Polymerase basic protein 2
著者Severin, C, Rocha de Moura, T, Liu, Y, Li, K, Zheng, X, Luo, M.
登録日2015-10-26
公開日2016-02-10
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The cap-binding site of influenza virus protein PB2 as a drug target.
Acta Crystallogr D Struct Biol, 72, 2016
5FN0
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BU of 5fn0 by Molmil
Crystal structure of Pseudomonas fluorescens kynurenine-3- monooxygenase (KMO) in complex with GSK180
分子名称: 3-(5,6-DICHLORO-2-OXOBENZO[D]OXAZOL-3(2H)-YL)PROPANOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, KYNURENINE 3-MONOOXYGENASE
著者Mole, D.J, Webster, S.P, Uings, I, Zheng, X, Binnie, M, Wilson, K, Hutchinson, J.P, Mirguet, O, Walker, A, Beaufils, B, Ancellin, N, Trottet, L, Beneton, V, Mowat, C.G, Wilkinson, M, Rowland, P, Haslam, C, McBride, A, Homer, N.Z.M, Baily, J.E, Sharp, M.G.F, Garden, O.J, Hughes, J, Howie, S.E.M, Holmes, D, Liddle, J, Iredale, J.P.
登録日2015-11-10
公開日2016-01-13
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.19 Å)
主引用文献Kynurenine-3-Monooxygenase Inhibition Prevents Multiple Organ Failure in Rodent Models of Acute Pancreatitis.
Nat.Med. (N.Y.), 22, 2016
6K8N
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BU of 6k8n by Molmil
Crystal structure of the Sulfolobus solfataricus topoisomerase III
分子名称: ZINC ION, topoisomerase III
著者Wang, H.Q, Zhang, J.H, Zheng, X, Zheng, Z.F, Dong, Y.H, Huang, L, Gong, Y.
登録日2019-06-13
公開日2020-06-24
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structures of the Sulfolobus solfataricus topoisomerase III reveal that its C-terminal novel zinc finger part is a unique decatenation domain
To Be Published
6K8O
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BU of 6k8o by Molmil
Crystal structure of the Sulfolobus solfataricus topoisomerase III in complex with DNA
分子名称: DNA (5'-D(*GP*CP*AP*AP*GP*GP*TP*C)-3'), ZINC ION, topoisomerase III
著者Wang, H.Q, Zhang, J.H, Zheng, X, Zheng, Z.F, Dong, Y.H, Huang, L, Gong, Y.
登録日2019-06-13
公開日2020-06-24
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structures of the Sulfolobus solfataricus topoisomerase III reveal that its C-terminal novel zinc finger part is a unique decatenation domain
To Be Published
4Q46
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BU of 4q46 by Molmil
The second structure of Influenza B PB2 cap-binding domain complex with GDP
分子名称: GUANOSINE-5'-DIPHOSPHATE, Polymerase basic protein 2
著者Liu, Y, Yang, Y, Zheng, X.
登録日2014-04-13
公開日2015-02-25
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The crystal structure of the PB2 cap-binding domain of influenza B virus reveals a novel cap recognition mechanism.
J.Biol.Chem., 290, 2015
4OR6
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BU of 4or6 by Molmil
Structure of Influenza B PB2 cap-binding domain with Q325F mutation complex with GDP
分子名称: GUANOSINE-5'-DIPHOSPHATE, Polymerase basic protein 2
著者Liu, Y, Fan, J, Zheng, X.
登録日2014-02-11
公開日2015-02-25
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.293 Å)
主引用文献The crystal structure of the PB2 cap-binding domain of influenza B virus reveals a novel cap recognition mechanism.
J.Biol.Chem., 290, 2015
4OR4
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BU of 4or4 by Molmil
Structure of Influenza B PB2 cap-binding domain with Q325F mutation complex with m7GDP
分子名称: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, Polymerase basic protein 2
著者Liu, Y, Fan, J, Zheng, X.
登録日2014-02-10
公開日2015-02-25
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献The crystal structure of the PB2 cap-binding domain of influenza B virus reveals a novel cap recognition mechanism.
J.Biol.Chem., 290, 2015
4ORO
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BU of 4oro by Molmil
Structure of Influenza B PB2 cap-binding domain complex with GDP
分子名称: GUANOSINE-5'-DIPHOSPHATE, Polymerase PB2
著者Liu, Y, Zheng, X.
登録日2014-02-11
公開日2015-05-20
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of Influenza B PB2 cap-binding domain complex with GDP
to be published
6IM4
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BU of 6im4 by Molmil
Structural basis of AimP signaling molecule recognition by AimR in Spbeta group of bacteriophages
分子名称: AimR transcriptional regulator, GLY-MET-PRO-ARG-GLY-ALA
著者Ouyang, S.Y.
登録日2018-10-22
公開日2019-01-23
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Structural basis of AimP signaling molecule recognition by AimR in Spbeta group of bacteriophages.
Protein Cell, 10, 2019
5WS2
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BU of 5ws2 by Molmil
Crystal structure of mpy-RNase J (mutant S247A), an archaeal RNase J from Methanolobus psychrophilus R15, complex with RNA
分子名称: RNA (5'-R(P*AP*AP*AP*AP*A)-3'), Ribonuclease J, SULFATE ION, ...
著者Li, D.F, Feng, N.
登録日2016-12-05
公開日2017-12-06
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.398 Å)
主引用文献New molecular insights into an archaeal RNase J reveal a conserved processive exoribonucleolysis mechanism of the RNase J family
Mol. Microbiol., 106, 2017
5DZM
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BU of 5dzm by Molmil
HIV-1 Reverse Transcriptase RH domain
分子名称: Ribonuclease H
著者Pedersen, L.C, London, R.E, Gabel, S.A, Zheng, X.H.
登録日2015-09-25
公開日2016-05-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Unfolding the HIV-1 reverse transcriptase RNase H domain - how to lose a molecular tug-of-war.
Nucleic Acids Res., 44, 2016
5HAB
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BU of 5hab by Molmil
Crystal structure of mpy-RNase J (mutant H84A), an archaeal RNase J from Methanolobus psychrophilus R15, complex with RNA
分子名称: RNA (5'-R(P*AP*AP*AP*AP*A)-3'), Ribonuclease J, SULFATE ION
著者Li, D.F, Feng, N.
登録日2015-12-30
公開日2017-01-04
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Molecular insights into catalysis and processive exonucleolytic mechanisms of prokaryotic RNase J revealing striking parallels with that of eukaryotic Xrn1
To Be Published

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件を2024-07-24に公開中

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