8GPU
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![BU of 8gpu by Molmil](/molmil-images/mine/8gpu) | YFV_E_YD6Fab_prefusion | 分子名称: | Envelope protein, YD6Fab_H, YD6Fab_L | 著者 | Li, Y, Wu, L, Qi, J, Yan, J, Gao, G.F. | 登録日 | 2022-08-27 | 公開日 | 2022-11-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | 主引用文献 | A neutralizing-protective supersite of human monoclonal antibodies for yellow fever virus. Innovation (N Y), 3, 2022
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8GPT
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![BU of 8gpt by Molmil](/molmil-images/mine/8gpt) | YFV_E_YD6scFv_postfusion | 分子名称: | Envelope protein, YD6_VH, YD6_VL | 著者 | Li, Y, Wu, L, Qi, J, Yan, J, Gao, G.F. | 登録日 | 2022-08-27 | 公開日 | 2022-11-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.07 Å) | 主引用文献 | A neutralizing-protective supersite of human monoclonal antibodies for yellow fever virus. Innovation (N Y), 3, 2022
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6W25
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![BU of 6w25 by Molmil](/molmil-images/mine/6w25) | Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with SHU9119 | 分子名称: | CALCIUM ION, Melanocortin receptor 4,GlgA glycogen synthase,Melanocortin receptor 4, OLEIC ACID, ... | 著者 | Yu, J, Gimenez, L.E, Hernandez, C.C, Wu, Y, Wein, A.H, Han, G.W, McClary, K, Mittal, S.R, Burdsall, K, Stauch, B, Wu, L, Stevens, S.N, Peisley, A, Williams, S.Y, Chen, V, Millhauser, G.L, Zhao, S, Cone, R.D, Stevens, R.C. | 登録日 | 2020-03-04 | 公開日 | 2020-04-29 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Determination of the melanocortin-4 receptor structure identifies Ca2+as a cofactor for ligand binding. Science, 368, 2020
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4DGP
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![BU of 4dgp by Molmil](/molmil-images/mine/4dgp) | The wild-type Src homology 2 (SH2)-domain containing protein tyrosine phosphatase-2 (SHP2) | 分子名称: | Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Yu, Z.H, Xu, J, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L.N, Liu, S.J, Zhang, Z.Y. | 登録日 | 2012-01-26 | 公開日 | 2013-03-06 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations. J.Biol.Chem., 288, 2013
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4DGX
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![BU of 4dgx by Molmil](/molmil-images/mine/4dgx) | LEOPARD Syndrome-Associated SHP2/Y279C mutant | 分子名称: | Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Yu, Z.H, Xu, J, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L.N, Liu, S.J, Zhang, Z.Y. | 登録日 | 2012-01-27 | 公開日 | 2013-03-06 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations. J.Biol.Chem., 288, 2013
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7PSI
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![BU of 7psi by Molmil](/molmil-images/mine/7psi) | Crystal structure of beta-glucuronidase from Acidobacterium capsulatum in complex with covalent inhibitor ME727 | 分子名称: | (2R,3S,5R,6R)-2,3,4,5,6-pentakis(oxidanyl)cyclohexane-1-carboxylic acid, Beta-glucuronidase, SULFATE ION | 著者 | Armstrong, Z, Wu, L, Davies, G.J. | 登録日 | 2021-09-23 | 公開日 | 2022-08-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo. Proc.Natl.Acad.Sci.USA, 119, 2022
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7PSK
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![BU of 7psk by Molmil](/molmil-images/mine/7psk) | Crystal structure of beta-glucuronidase from Acidobacterium capsulatum in complex with covalent inhibitor GR109 | 分子名称: | 2-acetamido-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-(2R,3S,5R,6R)-2,3,4,5,6-pentakis(oxidanyl)cyclohexane-1-carboxylic acid, Beta-glucuronidase | 著者 | Armstrong, Z, Wu, L, Davies, G.J. | 登録日 | 2021-09-23 | 公開日 | 2022-08-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.09 Å) | 主引用文献 | Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo. Proc.Natl.Acad.Sci.USA, 119, 2022
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7PSH
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![BU of 7psh by Molmil](/molmil-images/mine/7psh) | |
7PSJ
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![BU of 7psj by Molmil](/molmil-images/mine/7psj) | Crystal structure of beta-glucuronidase from Acidobacterium capsulatum in complex with covalent inhibitor VL166 | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-(2R,3S,5R,6R)-2,3,4,5,6-pentakis(oxidanyl)cyclohexane-1-carboxylic acid, Beta-glucuronidase | 著者 | Armstrong, Z, Wu, L, Davies, G.J. | 登録日 | 2021-09-23 | 公開日 | 2022-08-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo. Proc.Natl.Acad.Sci.USA, 119, 2022
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7PLS
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![BU of 7pls by Molmil](/molmil-images/mine/7pls) | Cryo-EM structures of human fucosidase FucA1 reveal insight into substate recognition and catalysis. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Tissue alpha-L-fucosidase | 著者 | Armstrong, Z, Meek, R.W, Wu, L, Blaza, J.N, Davies, G.J. | 登録日 | 2021-09-01 | 公開日 | 2022-08-10 | 最終更新日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (2.49 Å) | 主引用文献 | Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis. Structure, 30, 2022
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7PM4
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![BU of 7pm4 by Molmil](/molmil-images/mine/7pm4) | Cryo-EM structures of human fucosidase FucA1 reveal insight into substate recognition and catalysis. | 分子名称: | (2S,3R,4S,5R)-2-METHYLPIPERIDINE-3,4,5-TRIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Tissue alpha-L-fucosidase | 著者 | Armstrong, Z, Meek, R.W, Wu, L, Blaza, J.N, Davies, G.J. | 登録日 | 2021-09-01 | 公開日 | 2022-08-10 | 最終更新日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (2.49 Å) | 主引用文献 | Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis. Structure, 30, 2022
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4OHL
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![BU of 4ohl by Molmil](/molmil-images/mine/4ohl) | LEOPARD Syndrome-Associated SHP2/T468M mutant | 分子名称: | Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y. | 登録日 | 2014-01-17 | 公開日 | 2014-09-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations. Biochemistry, 53, 2014
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4OHH
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![BU of 4ohh by Molmil](/molmil-images/mine/4ohh) | LEOPARD Syndrome-Associated SHP2/Q506P mutant | 分子名称: | Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y. | 登録日 | 2014-01-17 | 公開日 | 2014-09-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations. Biochemistry, 53, 2014
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8OHX
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![BU of 8ohx by Molmil](/molmil-images/mine/8ohx) | Crystal structure of Beta-glucuronidase from Escherichia coli in complex with siastatin B derived inhibitor | 分子名称: | (3~{S},4~{S},5~{S},6~{R})-4,5,6-tris(oxidanyl)piperidine-3-carboxylic acid, Beta-D-glucuronidase | 著者 | Armstrong, Z, Yurong, C, Wu, L, Overkleeft, H.S, Davies, G.J. | 登録日 | 2023-03-21 | 公開日 | 2024-01-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Molecular Basis for Inhibition of Heparanases and beta-Glucuronidases by Siastatin B. J.Am.Chem.Soc., 146, 2024
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8OHV
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![BU of 8ohv by Molmil](/molmil-images/mine/8ohv) | Crystal structure of Beta-glucuronidase from Acidobacterium capsulatum in complex with glucuronic acid configured 3-geminal diol iminosugar inhibitor | 分子名称: | (3~{S},4~{R})-4,5,5-tris(oxidanyl)piperidine-3-carboxylic acid, SULFATE ION, beta-glucuronidase from Acidobacterium capsulatum | 著者 | Armstrong, Z, Yurong, C, Wu, L, Overkleeft, H.S, Davies, G.J. | 登録日 | 2023-03-21 | 公開日 | 2024-01-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Molecular Basis for Inhibition of Heparanases and beta-Glucuronidases by Siastatin B. J.Am.Chem.Soc., 146, 2024
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8OHR
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![BU of 8ohr by Molmil](/molmil-images/mine/8ohr) | Crystal structure of human heparanase in complex with glucuronic acid configured 3-geminal diol iminosugar inhibitor | 分子名称: | (3~{S},4~{R})-4,5,5-tris(oxidanyl)piperidine-3-carboxylic acid, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Armstrong, Z, Yurong, C, Wu, L, Overkleeft, H.S, Davies, G.J. | 登録日 | 2023-03-21 | 公開日 | 2024-01-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Molecular Basis for Inhibition of Heparanases and beta-Glucuronidases by Siastatin B. J.Am.Chem.Soc., 146, 2024
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8OHW
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![BU of 8ohw by Molmil](/molmil-images/mine/8ohw) | Crystal structure of heparanase from Burkholderia pseudomallei in complex with siastatin B derived inhibitor | 分子名称: | (3~{S},4~{S},5~{S},6~{R})-4,5,6-tris(oxidanyl)piperidine-3-carboxylic acid, 1,2-ETHANEDIOL, Glycoside hydrolase family 44 domain-containing protein | 著者 | Armstrong, Z, Yurong, C, Wu, L, Overkleeft, H.S, Davies, G.J. | 登録日 | 2023-03-21 | 公開日 | 2024-01-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | 主引用文献 | Molecular Basis for Inhibition of Heparanases and beta-Glucuronidases by Siastatin B. J.Am.Chem.Soc., 146, 2024
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8OHT
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![BU of 8oht by Molmil](/molmil-images/mine/8oht) | Crystal structure of Beta-glucuronidase from Acidobacterium capsulatum in complex with competitive inhibitor derrived from siastatin B | 分子名称: | (3~{S},4~{S},5~{S},6~{R})-4,5,6-tris(oxidanyl)piperidine-3-carboxylic acid, SULFATE ION, beta-glucuronidase from Acidobacterium capsulatum | 著者 | Armstrong, Z, Yurong, C, Wu, L, Overkleeft, H.S, Davies, G.J. | 登録日 | 2023-03-21 | 公開日 | 2024-01-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | Molecular Basis for Inhibition of Heparanases and beta-Glucuronidases by Siastatin B. J.Am.Chem.Soc., 146, 2024
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8OHU
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![BU of 8ohu by Molmil](/molmil-images/mine/8ohu) | Crystal structure of Beta-glucuronidase from Acidobacterium capsulatum in complex with glucuronic acid configured isofagamine | 分子名称: | (3S,4R,5R)-4,5-dihydroxypiperidine-3-carboxylic acid, beta-glucuronidase from Acidobacterium capsulatum | 著者 | Armstrong, Z, Yurong, C, Wu, L, Overkleeft, H.S, Davies, G.J. | 登録日 | 2023-03-21 | 公開日 | 2024-01-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Molecular Basis for Inhibition of Heparanases and beta-Glucuronidases by Siastatin B. J.Am.Chem.Soc., 146, 2024
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8OGX
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![BU of 8ogx by Molmil](/molmil-images/mine/8ogx) | Beta-glucuronidase from Acidobacterium capsulatum in complex with inhibitor R3794 | 分子名称: | (3~{S},4~{S})-4,5,5-tris(oxidanyl)piperidine-3-carboxylic acid, PHOSPHATE ION, beta-glucuronidase from Acidobacterium capsulatum | 著者 | Moran, E.M, Davies, G.J, Chen, C, Nieuwendijk, E.V, Wu, L, Skoulikopoulou, F, Riet, V.V, Overkleeft, H.S, Armstrong, Z. | 登録日 | 2023-03-20 | 公開日 | 2024-01-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Molecular Basis for Inhibition of Heparanases and beta-Glucuronidases by Siastatin B. J.Am.Chem.Soc., 146, 2024
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4OHI
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![BU of 4ohi by Molmil](/molmil-images/mine/4ohi) | LEOPARD Syndrome-Associated SHP2/Q510E mutant | 分子名称: | Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y. | 登録日 | 2014-01-17 | 公開日 | 2014-09-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations. Biochemistry, 53, 2014
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4GA7
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![BU of 4ga7 by Molmil](/molmil-images/mine/4ga7) | Crystal structure of human serpinB1 mutant | 分子名称: | Leukocyte elastase inhibitor | 著者 | Wang, L, Li, Q, Wu, L, Zhang, K, Tong, L, Sun, F, Fan, Z. | 登録日 | 2012-07-25 | 公開日 | 2013-01-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Identification of SERPINB1 as a physiological inhibitor of human granzyme H J.Immunol., 190, 2013
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4GAW
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![BU of 4gaw by Molmil](/molmil-images/mine/4gaw) | Crystal structure of active human granzyme H | 分子名称: | CHLORIDE ION, Granzyme H, SULFATE ION | 著者 | Wang, L, Li, Q, Wu, L, Zhang, K, Tong, L, Sun, F, Fan, Z. | 登録日 | 2012-07-25 | 公開日 | 2013-01-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Identification of SERPINB1 as a physiological inhibitor of human granzyme H J.Immunol., 190, 2013
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1PA9
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![BU of 1pa9 by Molmil](/molmil-images/mine/1pa9) | Yersinia Protein-Tyrosine Phosphatase complexed with pNCS (Yop51,Pasteurella X,Ptpase,Yop51delta162) (Catalytic Domain, Residues 163-468) Mutant With Cys 235 Replaced By Arg (C235r) | 分子名称: | N,4-DIHYDROXY-N-OXO-3-(SULFOOXY)BENZENAMINIUM, Protein-tyrosine phosphatase yopH | 著者 | Sun, J.P, Wu, L, Fedorov, A.A, Almo, S.C, Zhang, Z.Y. | 登録日 | 2003-05-13 | 公開日 | 2003-11-04 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of the Yersinia protein-tyrosine phosphatase YopH complexed
with a specific small molecule inhibitor J.BIOL.CHEM., 278, 2003
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3O5X
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![BU of 3o5x by Molmil](/molmil-images/mine/3o5x) | Crystal structure of the oncogenic tyrosine phosphatase SHP2 complexed with a salicylic acid-based small molecule inhibitor | 分子名称: | 3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3-triazol-4-yl}-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Zhang, Z.-Y, Zhang, X, He, Y, Liu, S, Yu, Z, Jiang, Z, Yang, Z, Dong, Y, Nabinger, S.C, Wu, L, Gunawan, A.M, Wang, L, Chan, R.J. | 登録日 | 2010-07-28 | 公開日 | 2010-08-11 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). J.Med.Chem., 53, 2010
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