7TPJ
| Single-Particle Cryo-EM Structure of the WaaL O-antigen ligase in its apo state | 分子名称: | Fab Heavy (H) Chain, Fab Light (L) Chain, Putative cell surface polysaccharide polymerase/ligase | 著者 | Ashraf, K.U, Nygaard, R, Vickery, O.N, Erramilli, S.K, Herrera, C.M, McConville, T.H, Petrou, V.I, Giacometti, S.I, Dufrisne, M.B, Nosol, K, Zinkle, A.P, Graham, C.L.B, Loukeris, M, Kloss, B, Skorupinska-Tudek, K, Swiezewska, E, Roper, D, Clarke, O.B, Uhlemann, A.C, Kossiakoff, A.A, Trent, M.S, Stansfeld, P.J, Mancia, F. | 登録日 | 2022-01-25 | 公開日 | 2022-04-06 | 最終更新日 | 2022-04-27 | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | 主引用文献 | Structural basis of lipopolysaccharide maturation by the O-antigen ligase. Nature, 604, 2022
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2P49
| Complex of a camelid single-domain vhh antibody fragment with RNASE A at 1.4A resolution: native mono_1 crystal form | 分子名称: | ANTIBODY CAB-RN05, PHOSPHATE ION, Ribonuclease pancreatic | 著者 | Tereshko, V, Uysal, S, Margalef, K, Koide, A, Kossiakoff, A.A, Koide, S. | 登録日 | 2007-03-11 | 公開日 | 2007-08-28 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope. J.Mol.Biol., 373, 2007
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2P42
| Complex of a camelid single-domain vhh antibody fragment with RNASE A at 1.8A resolution: SE3-mono-2 crystal form with three se-met sites (M34, M51, M83) in vhh scaffold | 分子名称: | ANTIBODY CAB-RN05, MAGNESIUM ION, Ribonuclease pancreatic | 著者 | Tereshko, V, Uysal, S, Koide, A, Margalef, K, Koide, S, Kossiakoff, A.A. | 登録日 | 2007-03-11 | 公開日 | 2008-03-11 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Toward chaperone-assisted crystallography: protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffold Protein Sci., 17, 2008
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2P48
| Complex of a camelid single-domain vhh antibody fragment with RNASE A at 2.3A resolution: SE5B-tetra crystal form with five se-met sites (L4M, M34, M51, F68M, M83) in vhh scaffold. | 分子名称: | ANTIBODY CAB-RN05, Ribonuclease pancreatic, SULFATE ION | 著者 | Tereshko, V, Uysal, S, Koide, A, Margalef, K, Koide, S, Kossiakoff, A.A. | 登録日 | 2007-03-11 | 公開日 | 2008-03-11 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Toward chaperone-assisted crystallography: protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffold Protein Sci., 17, 2008
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2P45
| Complex of a camelid single-domain vhh antibody fragment with RNASE A at 1.1A resolution: SE5B-ORTHO-1 crystal form with five se-met sites (L4M, M34, M51, F68M, M83) in vhh scaffold. | 分子名称: | ANTIBODY CAB-RN05, Ribonuclease pancreatic, SULFATE ION | 著者 | Tereshko, V, Uysal, S, Koide, A, Margalef, K, Koide, S, Kossiakoff, A.A. | 登録日 | 2007-03-11 | 公開日 | 2008-03-11 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Toward chaperone-assisted crystallography: protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffold Protein Sci., 17, 2008
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2P47
| Complex of a camelid single-domain vhh antibody fragment with RNASE A at 2.5A resolution: SE5B-TRI crystal form with five se-met sites (L4M, M34, M51, F68M, M83) in vhh scaffold. | 分子名称: | ANTIBODY CAB-RN05, Ribonuclease pancreatic | 著者 | Tereshko, V, Uysal, S, Koide, A, Margalef, K, Koide, S, Kossiakoff, A.A. | 登録日 | 2007-03-11 | 公開日 | 2008-03-11 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Toward chaperone-assisted crystallography: protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffold Protein Sci., 17, 2008
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2P44
| Complex of a camelid single-domain vhh antibody fragment with RNASE A at 1.8A resolution: SE5A-mono-1 crystal form with five se-met sites (M34, M51, F68M, M83, L86M) in vhh scaffold | 分子名称: | ANTIBODY CAB-RN05, Ribonuclease pancreatic | 著者 | Tereshko, V, Uysal, S, Koide, A, Margalef, K, Koide, S, Kossiakoff, A.A. | 登録日 | 2007-03-11 | 公開日 | 2008-03-11 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Toward chaperone-assisted crystallography: protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffold Protein Sci., 17, 2008
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2P43
| Complex of a camelid single-domain vhh antibody fragment with RNASE A at 1.65A resolution: SE3-mono-1 crystal form with three se-met sites (M34, M51, M83) in vhh scaffold | 分子名称: | ANTIBODY CAB-RN05, Ribonuclease pancreatic | 著者 | Tereshko, V, Uysal, S, Koide, A, Margalef, K, Koide, S, Kossiakoff, A.A. | 登録日 | 2007-03-11 | 公開日 | 2008-03-11 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Toward chaperone-assisted crystallography: protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffold Protein Sci., 17, 2008
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2PNE
| Crystal Structure of the Snow Flea Antifreeze Protein | 分子名称: | 6.5 kDa glycine-rich antifreeze protein | 著者 | Pentelute, B.L, Kent, S.B.H, Gates, Z.P, Tereshko, V, Kossiakoff, A.A, Kurutz, J, Dashnau, J, Vaderkooi, J.M. | 登録日 | 2007-04-24 | 公開日 | 2008-04-29 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (0.98 Å) | 主引用文献 | X-ray structure of snow flea antifreeze protein determined by racemic crystallization of synthetic protein enantiomers J.Am.Chem.Soc., 130, 2008
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2P46
| Complex of a camelid single-domain vhh antibody fragment with RNASE A at 2.5A resolution: se5b-ortho-2 crystal form with five se-met sites (L4M, M34, M51, F68M, M83) in vhh scaffold. | 分子名称: | ANTIBODY CAB-RN05, Ribonuclease pancreatic, ZINC ION | 著者 | Tereshko, V, Uysal, S, Koide, A, Margalef, K, Koide, S, Kossiakoff, A.A. | 登録日 | 2007-03-11 | 公開日 | 2008-03-11 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Toward chaperone-assisted crystallography: protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffold Protein Sci., 17, 2008
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8RQF
| Cryo-EM structure of human NTCP-Bulevirtide complex | 分子名称: | Fab-specific nanobody, Heavy chain of Fab3, Light chain of Fab3, ... | 著者 | Liu, H, Zakrzewicz, D, Nosol, K, Irobalieva, R.N, Mukherjee, S, Bang-Soerensen, R, Goldmann, N, Kunz, S, Rossi, L, Kossiakoff, A.A, Urban, S, Glebe, D, Geyer, J, Locher, K.P. | 登録日 | 2024-01-18 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | 主引用文献 | Cryo-EM structure of human NTCP-Bulevirtide complex To Be Published
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8T6I
| Structure of VHH-Fab complex with engineered Crystal Kappa region | 分子名称: | Fab heavy chain, Fab light chain, GLYCEROL, ... | 著者 | Filippova, E.V, Thompson, I, Kossiakoff, A.A. | 登録日 | 2023-06-16 | 公開日 | 2023-11-29 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes. Protein Sci., 33, 2024
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8T9Y
| Structure of VHH-Fab complex with engineered Elbow FNQIKG and Crystal Kappa regions | 分子名称: | DI(HYDROXYETHYL)ETHER, Fab heavy chain, Fab light chain, ... | 著者 | Filippova, E.V, Thompson, I, Kossiakoff, A.A. | 登録日 | 2023-06-26 | 公開日 | 2023-11-29 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes. Protein Sci., 33, 2024
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8T58
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8T8I
| Structure of VHH-Fab complex with engineered Elbow FNQIKG, Crystal Kappa and SER substitutions | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Fab heavy chain, ... | 著者 | Filippova, E.V, Thompson, I, Kossiakoff, A.A. | 登録日 | 2023-06-22 | 公開日 | 2023-11-29 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes. Protein Sci., 33, 2024
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8THE
| Cryo-EM structure of Pseudomonas aeruginosa TonB-dependent transporter PhuR in complex with synthetic antibody and heme | 分子名称: | (2~{R},4~{R},5~{S},6~{S})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[[(2~{R},3~{S},4~{S},5~{R},6~{S})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{R},4~{R},5~{S},6~{S})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{S})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-4,5-bis(oxidanyl)oxane-2-carboxylic acid, Heme/hemoglobin uptake outer membrane receptor PhuR, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Knejski, P, Erramilli, S.K, Kossiakoff, A.A. | 登録日 | 2023-07-15 | 公開日 | 2024-01-31 | 最終更新日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Chaperone-assisted cryo-EM structure of P. aeruginosa PhuR reveals molecular basis for heme binding. Structure, 32, 2024
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7JHG
| Cryo-EM structure of ATP-bound fully inactive AMPK in complex with Dorsomorphin (Compound C) and Fab-nanobody | 分子名称: | 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... | 著者 | Yan, Y, Murkherjee, S, Zhou, X.E, Xu, T.H, Xu, H.E, Kossiakoff, A.A, Melcher, K. | 登録日 | 2020-07-20 | 公開日 | 2021-07-21 | 最終更新日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | 主引用文献 | Structure of an AMPK complex in an inactive, ATP-bound state. Science, 373, 2021
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7JHH
| Cryo-EM structure of ATP-bound fully inactive AMPK in complex with Fab and nanobody | 分子名称: | 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... | 著者 | Yan, Y, Murkherjee, S, Zhou, X.E, Xu, T.H, Xu, H.E, Kossiakoff, A.A, Melcher, K. | 登録日 | 2020-07-20 | 公開日 | 2021-07-21 | 最終更新日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (3.92 Å) | 主引用文献 | Structure of an AMPK complex in an inactive, ATP-bound state. Science, 373, 2021
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7MJS
| Single-Particle Cryo-EM Structure of Major Facilitator Superfamily Domain containing 2A in complex with LPC-18:3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2AG3 Fab heavy chain, 2AG3 Fab light chain, ... | 著者 | Cater, R.J, Chua, G.L, Erramilli, S.K, Keener, J.E, Choy, B.C, Tokarz, P, Chin, C.F, Quek, D.Q.Y, Kloss, B, Pepe, J.G, Parisi, G, Wong, B.H, Clarke, O.B, Marty, M.T, Kossiakoff, A.A, Khelashvili, G, Silver, D.L, Mancia, F. | 登録日 | 2021-04-20 | 公開日 | 2021-06-16 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | 主引用文献 | Structural basis of omega-3 fatty acid transport across the blood-brain barrier. Nature, 595, 2021
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7MO1
| Crystal Structure of the ZnF1 of Nucleoporin NUP153 in complex with Ran-GDP | 分子名称: | GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | 登録日 | 2021-05-01 | 公開日 | 2022-06-15 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
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7MNW
| Crystal Structure of Nup358/RanBP2 Ran-binding domain 1 in complex with Ran-GPPNHP | 分子名称: | E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, MAGNESIUM ION, ... | 著者 | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | 登録日 | 2021-05-01 | 公開日 | 2022-06-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
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7MNZ
| Crystal Structure of Nup358/RanBP2 Ran-binding domain 4 in complex with Ran-GPPNHP | 分子名称: | E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, MAGNESIUM ION, ... | 著者 | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | 登録日 | 2021-05-01 | 公開日 | 2022-06-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
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7MNJ
| Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 145-673) | 分子名称: | E3 SUMO-protein ligase RanBP2 | 著者 | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Patke, A, Dasso, M, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | 登録日 | 2021-05-01 | 公開日 | 2022-06-15 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
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7MO0
| Crystal Structure of Nucleoporin NUP50 Ran-Binding Domain in Complex with Ran-GPPNHP | 分子名称: | GTP-binding nuclear protein Ran, MAGNESIUM ION, Nuclear pore complex protein Nup50, ... | 著者 | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | 登録日 | 2021-05-01 | 公開日 | 2022-06-15 | 最終更新日 | 2022-06-22 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
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7MNP
| Crystal Structure of the ZnF2 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP | 分子名称: | E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | 登録日 | 2021-05-01 | 公開日 | 2022-06-15 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
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